Predictive Model Developed for In-Hospital Mortality in TAVR

This article originally appeared here.
Share this content:
Predictive Model Developed for In-Hospital Mortality in TAVR
Predictive Model Developed for In-Hospital Mortality in TAVR

THURSDAY, March 10, 2016 (HealthDay News) -- A predictive model has been developed and validated for in-hospital mortality among patients undergoing transcatheter aortic valve replacement (TAVR); the findings were published online March 9 in JAMA Cardiology.

Fred H. Edwards, M.D., from the University of Florida College of Medicine in Jacksonville, and colleagues used patient data from a national registry for 13,718 patients undergoing TAVR to develop a statistical model that will predict in-hospital mortality after TAVR. The model was validated using 6,868 records for consecutive patients undergoing TAVR.

The researchers found that in-hospital mortality occurred in 5.3 percent of patients. The C-statistic for discrimination was 0.67 and 0.66, respectively, in the development and validation groups. Covariates in the final model included age (odds ratio [OR], 1.13), glomerular filtration rate per 5-unit increments (OR, 0.93), hemodialysis (OR, 3.25), New York Heart Association functional class IV (OR, 1.25), severe chronic lung disease (OR, 1.67), nonfemoral access site (OR, 1.96), and procedural acuity categories 2, 3, and 4 (ORs, 1.57, 2.70, and 3.34, respectively). No significant difference was seen between the model calibration line and the ideal calibration line.

"This model should be a valuable adjunct for patient counseling, local quality improvement, and national monitoring for appropriateness of selection of patients for TAVR," the authors write.

Several authors disclosed financial ties to the pharmaceutical and medical device industries.

Abstract
Full Text
Editorial

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists Should Counsel Patients Fasting for Ramadan

Pharmacists can suggest adjustments for meds taken several times per day, those affected by food intake

AUA: Many Have Unused Opioids After Urologic Procedures

AUA: Many Have Unused Opioids After Urologic Procedures

Patients use just over half of initial prescription; highest percentage of unused meds for cystectomy

Over Half of Young Adult Smoke Volume Exposure From Hookahs

Over Half of Young Adult Smoke Volume Exposure ...

Toxicant exposure to tar, carbon monoxide, nicotine lower, but still substantial, compared to cigarettes

is free, fast, and customized just for you!

Already a member?

Sign In Now »