Pravastatin Does Not Improve Survival in Small-Cell Lung Cancer

This article originally appeared here.
Share this content:
Pravastatin Does Not Improve Survival in Small-Cell Lung Cancer
Pravastatin Does Not Improve Survival in Small-Cell Lung Cancer

THURSDAY, March 2, 2017 (HealthDay News) -- For patients with small-cell lung cancer (SCLC), addition of pravastatin to standard chemotherapy does not improve survival, according to a study published online Feb. 27 in the Journal of Clinical Oncology.

Michael J. Seckl, M.D., from Imperial College London, and colleagues randomized patients with confirmed SCLC and performance status 0 to 3 to receive daily pravastatin 40 mg or placebo combined with up to six cycles of etoposide plus cisplatin or carboplatin every three weeks. A total of 846 patients from 91 U.K. hospitals were recruited.

The researchers found that there were 758 deaths and 787 progression-free survival (PFS) events among the cohort. There was no benefit seen for pravastatin in all patients or in specific patient subgroups. The two-year overall survival (OS) rate was 13.2 versus 14.1 percent for pravastatin versus placebo, with a hazard ratio of 1.01 (95 percent confidence interval, 0.88 to 1.16; P = 0.90). The median OS and PFS were 10.6 versus 10.7 months and 7.7 versus 7.3 months, respectively. For limited disease, the median OS was 14.6 months for pravastatin and placebo, compared with 9.1 and 8.8 months, respectively, for extensive disease. Similar adverse events were seen between the groups.

"Pravastatin 40 mg combined with standard SCLC therapy, although safe, does not benefit patients," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Air Pollution May Damage Kidneys

Air Pollution May Damage Kidneys

Study finds link between particulate matter and renal function

Diabetes Treatment Failure May Actually Be Nonadherence

Diabetes Treatment Failure May Actually Be Nonadherence

Second-line treatment often initiated without evidence of recommended use of first-line treatment

Effect of Osteoporotic Fractures Similar to Diabetes Burden

Effect of Osteoporotic Fractures Similar to Diabetes Burden

Findings for quality of life with hip fractures, vertebral compression vs. vision loss, amputation

is free, fast, and customized just for you!

Already a member?

Sign In Now »