PR Interval Prognostic of Cardiac Resynchronization Tx Outcome

Share this content:
PR Interval Prognostic of Cardiac Resynchronization Tx Outcome
PR Interval Prognostic of Cardiac Resynchronization Tx Outcome

WEDNESDAY, Feb. 15, 2017 (HealthDay News) -- For patients with advanced systolic heart failure, the impact of cardiac resynchronization therapy with defibrillation (CRT-D) varies according to PR interval, according to research published in the February issue of the Journal of Cardiovascular Electrophysiology.

Jeffrey Lin, M.D., from the University of Wisconsin School of Medicine and Public Health in Madison, and colleagues stratified 308 patients enrolled in the optimal pharmacologic therapy (OPT) and 595 patients in the CRT-D arms of the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure trial according to normal (≤230 ms) or prolonged (>230 ms) PR interval.

The researchers found that, compared with OPT, CRT-D treatment correlated with reduced hospitalization or all-cause mortality (ACM) and ACM (P = 0.002 and 0.003, respectively). In patients with longer baseline PR intervals, CRT-D was increasingly more effective in reducing ACM hazard (P = 0.002), irrespective of left bundle branch block (LBBB) status. ACM was reduced with CRT-D versus OPT (P = 0.001) in the prolonged baseline PR interval subgroup, with little evidence of a reduction in ACM in the normal PR subgroup (P = 0.07).

"In patients with advanced systolic heart failure, wide QRS complexes, and prolonged PR intervals, restoration of atrioventricular mechanical coupling with CRT-D may improve survival regardless of LBBB status," the authors write.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »