Potential New Asthma Genes ID'd in Genome-Wide Study

This article originally appeared here.
Share this content:
Potential New Asthma Genes ID'd in Genome-Wide Study
Potential New Asthma Genes ID'd in Genome-Wide Study

THURSDAY, July 28, 2016 (HealthDay News) -- Potential new asthma genes have been identified in a genome-wide association study (GWAS) combined with subsequent lung expression quantitative trait loci (eQTL) analysis, according to research published online July 20 in Allergy.

Maartje A. Nieuwenhuis, from the University of Groningen in the Netherlands, and colleagues performed a GWAS in 920 patients with asthma with bronchial hyper-responsiveness (BHR) and 980 controls. The top 368 single nucleotide polymorphisms (SNPs) were analyzed in four replication cohorts. Replicated SNPs underwent lung cis-eQTL analysis. The correlation of SNPs previously associated with asthma were examined in these data.

The researchers found that six SNPs replicated in one or more cohorts; after meta-analysis, one locus (17q21) achieved genome-wide significance. In whole lung tissue, five of six replicated SNPs regulated 35 gene transcripts. Significant correlations were seen with asthma and BHR for eight of 20 asthma-associated SNPs from previous GWASs. Larger effect sizes were seen for three SNPs (in IL-33 and GSDMB) in these data compared with the published literature.

"Combining GWAS with subsequent lung eQTL analysis revealed disease associated SNPs regulating lung mRNA expression levels of potential new asthma genes," the authors write.

Grant support was provided by the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Warns Against Children Taking Codeine, Tramadol

FDA Warns Against Children Taking Codeine, Tramadol

Agency strengthens warning labels on these medications to address dangers

Trump Administration Offers Grants to Fight Opioid Crisis

Trump Administration Offers Grants to Fight Opioid Crisis

Money to be used to train health professionals, foster prescription drug monitoring programs

NYC to Raise Cigarette Prices to Highest in the United States

NYC to Raise Cigarette Prices to Highest in ...

Price of pack to jump from $10.50 to $13.00

is free, fast, and customized just for you!

Already a member?

Sign In Now »