Post-Op Mortality Low Among HIV Patients Prescribed ART

This article originally appeared here.
Share this content:
Post-Op Mortality Low Among HIV Patients Prescribed ART
Post-Op Mortality Low Among HIV Patients Prescribed ART

(HealthDay News) -- Patients with HIV infection receiving antiretroviral therapy (ART) have increased 30-day postoperative mortality versus uninfected patients, although absolute incidence is low, according to a study published online Feb. 25 in JAMA Surgery.

Joseph T. King Jr., M.D., from the Veterans Affairs Connecticut Healthcare System in West Haven, and colleagues compared 30-day postoperative mortality in patients with HIV infection receiving ART with rates in uninfected individuals. Data from the U.S. Veterans Health Administration Healthcare System were obtained for Oct. 1, 1996, to Sept. 30, 2010, for 1,641 patients with HIV infection receiving combination ART and undergoing inpatient surgery and for 3,282 procedure-matched uninfected controls.

The researchers found that 30-day postoperative mortality was higher for patients with HIV infection versus uninfected patients (3.4 versus 1.6 percent; incidence rate ratio [IRR], 2.11; P < 0.001). There was an inverse association for CD4 cell count with mortality; HIV-1 RNA provided no additional information. Patients with HIV infection had increased mortality compared with uninfected patients at all CD4 cell count strata, after adjustment. Strong associations were also seen for hypoalbuminemia (IRR, 4.35) and age in decades (IRR, 1.47) with mortality.

"Current postoperative mortality rates among individuals with HIV infection who are receiving ART are low and are influenced as much by hypoalbuminemia and age as by CD4 cell status," the authors write. "Human immunodeficiency virus infection and CD4 cell count are only two of many factors associated with surgical outcomes that should be incorporated into surgical decision-making."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »