Post-Op A-Fib Down With Low-Level Vagus Nerve Stimulation

Share this content:
Post-Op A-Fib Down With Low-Level Vagus Nerve Stimulation
Post-Op A-Fib Down With Low-Level Vagus Nerve Stimulation

FRIDAY, June 2, 2017 (HealthDay News) -- For patients undergoing cardiac surgery, low-level vagus nerve stimulation (LLVNS) is associated with a reduction in postoperative atrial fibrillation (POAF) and with lower levels of inflammatory cytokines, according to a study published online May 31 in JACC: Clinical Electrophysiology.

Stavros Stavrakis, M.D., Ph.D., from the University of Oklahoma Health Sciences Center in Oklahoma City, and colleagues randomized 54 patients undergoing cardiac surgery to active or sham LLVNS (26 and 28, respectively). A bipolar wire was sutured to the vagus nerve preganglionic fibers alongside the lateral aspect of the superior vena cava in all patients. In the LLVNS group, high frequency stimulation, 50 percent below the threshold for slowing the heart rate, was delivered for 72 hours. Patients were monitored continuously during the hospital stay for development of POAF. Inflammatory cytokines were measured in blood collected on arrival to the intensive care unit and at 24 and 72 hours.

The researchers found that POAF occurred in 12 and 36 percent of the LLVNS and control groups, respectively (hazard ratio, 0.28). There were no complications resulting from wire placement. Compared with the control group, the LLVNS group had significantly lower serum tumor necrosis factor-α and interleukin-6 levels at 72 hours.

"These data suggest that LLVNS suppresses POAF and attenuates inflammation in patients undergoing cardiac surgery," the authors write. "Further studies are warranted."

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

Automated Central System Offers Time Savings for Pharmacists

Automated Central System Offers Time Savings for Pharmacists

Cart-fill process using new automated system is more efficient, frees up time for other roles

Therapeutic Horseback Riding Can Help Alleviate PTSD in Veterans

Therapeutic Horseback Riding Can Help Alleviate PTSD in ...

Study found statistically and clinically significant reduction in PTSD scores after six weeks of THR

Bariatric Surgery Linked to Discontinuing Diabetes Meds

Bariatric Surgery Linked to Discontinuing Diabetes Meds

Six-year antidiabetes treatment initiation rate also much lower after bariatric surgery

is free, fast, and customized just for you!

Already a member?

Sign In Now »