Poor Sensitivity for HPV 16/18 in Minor Abnormal Cytology

Share this content:
Poor Sensitivity for HPV 16/18 in Minor Abnormal Cytology
Poor Sensitivity for HPV 16/18 in Minor Abnormal Cytology

THURSDAY, Nov. 17, 2016 (HealthDay News) -- Testing for human papillomavirus (HPV) 16/18 has poor sensitivity for triaging women with minor abnormal cytology, according to a meta-analysis published online Nov. 15 in the Annals of Internal Medicine.

Marc Arbyn, M.D., from the Scientific Institute of Public Health in Brussels, and colleagues conducted a systematic literature review to examine the accuracy of genotyping for HPV types 16 and 18. Data were included for 24 moderate-to-good quality studies, involving 8,587 women with atypical squamous cells of undetermined significance (ASC-US) and 5,284 with low-grade squamous intraepithelial lesions (LSIL) who were triaged with tests for high-risk HPV (hrHPV) and HPV 16/18 to detect cervical intraepithelial neoplasia (CIN).

The researchers found that for women with either ASC-US or LSIL the pooled sensitivity of HPV 16/18 genotyping for CIN3+ was about 70 percent. With a threshold of grade <2 CIN, the pooled specificities were 83 and 76 percent, respectively, for women with ASC-US and LSIL. In HPV 16/18-positive women with ASC-US and LSIL, the average risk for CIN3+ was 17 and 19 percent, respectively, and was 5 percent in hrHPV-positive but HPV 16/18-negative women with ASC-US or LSIL.

"Testing for HPV 16/18 to triage women with minor abnormal cytology is poorly sensitive but may be useful as a second triage test after hrHPV testing, with direct referral if the woman is positive for HPV 16/18," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters


More in Home

Study Finds 31 Percent Use No Opioids After Surgery

Study Finds 31 Percent Use No Opioids After ...

At discharge, 92.2 percent of patients received an opioid prescription; nearly 63 percent unused

PAs May Have Lower Diagnostic Accuracy for Melanoma

PAs May Have Lower Diagnostic Accuracy for Melanoma

PAs diagnose fewer melanomas in situ, perform more skin biopsies per case of skin cancer diagnosed

AAN: Neuromodulation Therapy Gives Relief From Hand Tremor

AAN: Neuromodulation Therapy Gives Relief From Hand Tremor

Non-invasive neuromodulation therapy using a custom stimulation pattern safe for essential tremor

is free, fast, and customized just for you!

Already a member?

Sign In Now »