Polypharmacy Linked to Poorer Cognitive, Physical Capability

Share this content:
Polypharmacy Linked to Poorer Cognitive, Physical Capability
Polypharmacy Linked to Poorer Cognitive, Physical Capability

MONDAY, April 9, 2018 (HealthDay News) -- Polypharmacy is associated with poorer cognitive and physical capability even after adjustment for disease burden, according to a study published online March 24 in the Journal of the American Geriatrics Society.

Mark James Rawle, M.B.Ch.B., from University College London, and colleagues conducted a prospective birth cohort study to examine longitudinal correlations between polypharmacy and cognitive and physical capability. An eligible sample of 2,122 men and women with medication data at age 69 years participated.

The researchers found that 18.2 percent of the participants had polypharmacy (five to eight prescribed medications) and 4.7 percent had excessive polypharmacy (nine or more medications) at age 69 years. In models adjusted for sex, education, and disease burden, both polypharmacy and excessive polypharmacy were correlated with poorer cognitive and physical capability, with stronger associations seen for excessive polypharmacy. Stronger negative associations with cognitive and physical capability were seen for participants with polypharmacy at both age 60 to 64 and at age 69 years.

"Future research aiming to improve cognitive and physical capability should consider interventions to reduce the duration and level of polypharmacy at younger ages, in addition to optimizing disease control with appropriate medications," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Medicare Requiring Hospitals to Post Prices Online

Medicare Requiring Hospitals to Post Prices Online

Medicare would base part of a hospital's payments on how easy it is for patients to access medical records

Restless Brain Syndrome Tied to Changes in the Brain

Restless Brain Syndrome Tied to Changes in the ...

Morphological differences seen in the primary somatosensory system

People With Opioid Use Disorder Have High Suicide Rate

People With Opioid Use Disorder Have High Suicide ...

Based on data from multiple sources, many opioid-overdose deaths seem to be suicides

is free, fast, and customized just for you!

Already a member?

Sign In Now »