Pollutant Exposure May Lead to Multi-Generational Asthma Risk

Share this content:
Pollutant Exposure May Lead to Multi-Generational Asthma Risk
Pollutant Exposure May Lead to Multi-Generational Asthma Risk

FRIDAY, July 21, 2017 (HealthDay News) -- Maternal exposure to diesel exhaust particles during pregnancy may increase susceptibility to allergic asthma in more than one generation of offspring, according to an experimental study published online recently in the American Journal of Physiology-Lung Cellular and Molecular Physiology.

David J. Gregory, M.B.B.S., M.P.H., Sc.D., from the Harvard T.H. Chan School of Public Health in Boston, and colleagues compared allergic susceptibility of three generations of BALB/c offspring after a single maternal exposure to diesel exhaust particles or concentrated urban air particles during pregnancy. The F1, F2, and F3 offspring were tested in a low-dose ovalbumin protocol for sensitivity to allergic asthma after receipt of intranasal instillations of particle suspensions or control.

The researchers found that following maternal exposure to particles during pregnancy there was elevated susceptibility, which persisted into F2, and with lesser magnitude, into F3 generations. Elevated eosinophil counts were seen in bronchoalveolar lavage fluid (BAL), histopathologic changes of allergic airway disease were observed, and there were increased BAL levels of interleukin (IL)-5 and IL-13. Distinct DNA methylation changes were identified in F1, F2, and F3 dendritic cells (DCs) using an enhanced reduced representation bisulfite sequencing protocol. The subset of altered loci shared across the three generations was associated with known allergy genes or pathways; some of the genes were linked to chromatin modification.

"The data indicate that pregnancy airway exposure to diesel exhaust particles triggers a transgenerationally transmitted asthma susceptibility and suggests a mechanistic role for epigenetic alterations in DCs in this process," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

High Success Rates for Mitral Valve Repair With Robotic Surgery

High Success Rates for Mitral Valve Repair With ...

Minimally invasive surgery linked to fewer discharges to facility, one day less in hospital vs conservative sx

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Tattoo-Linked Complications ID'd in Immunosuppressed Female

Inflammatory myopathy identified in woman with cystic fibrosis on long-term immunosuppressants

Rates of Cardiac Stress Testing Down but Still Higher in CKD

Rates of Cardiac Stress Testing Down but Still ...

Decline in rates of cardiac stress testing in Medicare beneficiaries aged ≥66 years from 2008 to 2012

is free, fast, and customized just for you!




Already a member?

Sign In Now »