Pilocarpine Expands Schlemm Canal in Healthy Eyes, Glaucoma

This article originally appeared here.
Share this content:
Pilocarpine Expands Schlemm Canal in Healthy Eyes, Glaucoma
Pilocarpine Expands Schlemm Canal in Healthy Eyes, Glaucoma

FRIDAY, June 24, 2016 (HealthDay News) -- Pilocarpine expands the Schlemm canal in eyes with and without glaucoma, according to a study published online June 23 in JAMA Ophthalmology.

Alon Skaat, M.D., from the New York Eye and Ear Infirmary of Mount Sinai in New York City, and colleagues examined the effect of pilocarpine on the structure of the Schlemm canal in vivo in a case-control study. Nine healthy individuals and 10 patients with open-angle glaucoma were prospectively enrolled after a complete ophthalmologic examination. Enhanced depth imaging optical coherence tomographic scans of the Schlemm canal were performed before and after topical pilocarpine administration (1 percent in healthy eyes and 2 percent in eyes with glaucoma).

The researchers found that the mean intraocular pressure decreased from 14.3 to 13.7 mm Hg in healthy eyes and from 17.5 to 16.6 mm Hg in eyes with glaucoma, following pilocarpine administration (P = 0.004 and 0.01, respectively). In healthy eyes and eyes with glaucoma, the mean cross-sectional area of the Schlemm canal increased by 21 and 24 percent, respectively (both P < 0.001). Significant increases were seen in the mean volume of the Schlemm canal in the overlapping area in both healthy eyes and eyes with glaucoma (both P < 0.001).

"These data suggest that pilocarpine expands the Schlemm canal in eyes with and without glaucoma," the authors write. "No differences in the effect were identified between the two groups."

Several authors disclosed financial ties to the medical device industry.

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Adding HIPEC to Cytoreductive Surgery Beneficial in Ovarian CA

Adding HIPEC to Cytoreductive Surgery Beneficial in Ovarian ...

Longer survival with hyperthermic intraperitoneal chemotherapy in stage III epithelial ovarian cancer

Chaplains Effective in Facilitating Advance Care Planning

Chaplains Effective in Facilitating Advance Care Planning

80 percent of patients who met chaplains in medical practice completed or provided advance directive

Alzheimer's Disease Variants Linked to Brain Amyloidosis

Alzheimer's Disease Variants Linked to Brain Amyloidosis

Significant correlations found for adenosine triphosphate-binding cassette subfamily A member

is free, fast, and customized just for you!

Already a member?

Sign In Now »