PFS Up With Obinutuzumab-Based Tx in Follicular Lymphoma

Share this content:
PFS Up With Obinutuzumab-Based Tx in Follicular Lymphoma
PFS Up With Obinutuzumab-Based Tx in Follicular Lymphoma

THURSDAY, Oct. 5, 2017 (HealthDay News) -- For patients with follicular lymphoma, obinutuzumab-based immunochemotherapy is associated with longer progression-free survival than rituximab-based therapy, according to a study published online Oct. 4 in the New England Journal of Medicine.

Robert Marcus, M.B.B.S., from King's College Hospital in the United Kingdom, and colleagues randomized 1,202 patients with follicular lymphoma to undergo induction treatment with obinutuzumab-based chemotherapy or rituximab-based chemotherapy (601 patients in each group). Patients who responded to treatment received maintenance treatment with the same antibody that they had received in induction for up to two years.

In a planned interim analysis conducted after a median follow-up of 34.5 months, the researchers found that obinutuzumab-based chemotherapy resulted in a significantly lower risk of progression, relapse, or death than rituximab-based chemotherapy (estimated three-year rate of progression-free survival, 80 versus 73.3 percent; hazard ratio for progression, relapse, or death, 0.66). The results were similar for independently reviewed progression-free survival and other time-to-event end points. The groups had similar response rates (88.5 and 86.9 percent in the obinutuzumab and rituximab groups, respectively). The obinutuzumab group had more frequent adverse events of grade 3 to 5 than the rituximab group (74.6 versus 67.8 percent), as well as more frequent serious adverse events (46.1 versus 39.9 percent).

"The replacement of rituximab with obinutuzumab in the context of immunochemotherapy and maintenance therapy in patients with previously untreated follicular lymphoma resulted in significantly longer progression-free survival," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including F. Hoffman-La Roche, which funded the study.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

Doctors Urged to Speak With Patients About Firearms

Doctors Urged to Speak With Patients About Firearms

Making a public commitment is encouraged as a positive action that physicians can take

Machine Learning Model Predicts Risk of Upgrade to Breast CA

Machine Learning Model Predicts Risk of Upgrade to ...

Model can predict risk of upgrade of high-risk breast lesions to cancer using traditional, text features

Glycemic Control Up With Oral Semaglutide in Type 2 Diabetes

Glycemic Control Up With Oral Semaglutide in Type ...

Phase 3 studies next to assess longer-term/clinical outcomes, safety

is free, fast, and customized just for you!

Already a member?

Sign In Now »