Peri-Op IV Acetaminophen May Reduce Post-Op Pain in Sinus Sx

Share this content:
Peri-Op IV Acetaminophen May Reduce Post-Op Pain in Sinus Sx
Peri-Op IV Acetaminophen May Reduce Post-Op Pain in Sinus Sx

THURSDAY, May 25, 2017 (HealthDay News) -- Perioperative intravenous acetaminophen (IVAPAP) may be beneficial for reducing immediate postoperative pain after endoscopic sinus surgery (ESS), although the results are inconclusive, according to a study published online May 25 in JAMA Otolaryngology-Head & Neck Surgery.

Matthew A. Tyler, M.D., from the McGovern Medical School in Houston, and colleagues conducted a prospective, randomized trial involving 62 patients undergoing ESS for chronic rhinosinusitis. Participants were randomized to receive 1 g of IVAPAP or 100 mL of placebo (saline infusions) before the start of surgery and four hours later (31 and 29 patients, respectively).

The researchers found that the mean pain scores were reduced in the IVAPAP versus the control group within the first hour, reaching a maximum difference of 7.7 mm on a visual analogue scale favoring the treatment group and with a true difference possibly as high as 22 mm, representing a clinically meaningful difference. The average pain scores were less in the placebo group, at 12 and 24 hours, with a clinically meaningful difference of 5.8 and 8.2 favoring the placebo group. The confidence intervals were wide and included the null value at all time points.

"The results of this study are inconclusive," the authors write. "The data suggest that perioperative intravenous acetaminophen may reduce immediate postoperative pain and opioid requirements compared with placebo and these differences could be clinically meaningful."

Several authors disclosed financial ties to the biopharmaceutical industry, including Mallinkrodt Pharma, which funded the study.

Abstract/Full Text
Editorial

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

For Hepatitis B Patients, Aspirin Tied to Lower Risk of HCC

For Hepatitis B Patients, Aspirin Tied to Lower ...

5 years of aspirin therapy linked to significantly lower incidence of hepatocellular carcinoma

High Percentage of HIV-Diagnosed Women Not in Care

High Percentage of HIV-Diagnosed Women Not in Care

62 percent of women with positive test had previously received the diagnosis but no care

CDC Updates Zika Guidance for Infant Care

CDC Updates Zika Guidance for Infant Care

Recommendations include evaluation and management of infants with possible infection

is free, fast, and customized just for you!

Already a member?

Sign In Now »