Peri-Op IV Acetaminophen May Reduce Post-Op Pain in Sinus Sx

Share this content:
Peri-Op IV Acetaminophen May Reduce Post-Op Pain in Sinus Sx
Peri-Op IV Acetaminophen May Reduce Post-Op Pain in Sinus Sx

THURSDAY, May 25, 2017 (HealthDay News) -- Perioperative intravenous acetaminophen (IVAPAP) may be beneficial for reducing immediate postoperative pain after endoscopic sinus surgery (ESS), although the results are inconclusive, according to a study published online May 25 in JAMA Otolaryngology-Head & Neck Surgery.

Matthew A. Tyler, M.D., from the McGovern Medical School in Houston, and colleagues conducted a prospective, randomized trial involving 62 patients undergoing ESS for chronic rhinosinusitis. Participants were randomized to receive 1 g of IVAPAP or 100 mL of placebo (saline infusions) before the start of surgery and four hours later (31 and 29 patients, respectively).

The researchers found that the mean pain scores were reduced in the IVAPAP versus the control group within the first hour, reaching a maximum difference of 7.7 mm on a visual analogue scale favoring the treatment group and with a true difference possibly as high as 22 mm, representing a clinically meaningful difference. The average pain scores were less in the placebo group, at 12 and 24 hours, with a clinically meaningful difference of 5.8 and 8.2 favoring the placebo group. The confidence intervals were wide and included the null value at all time points.

"The results of this study are inconclusive," the authors write. "The data suggest that perioperative intravenous acetaminophen may reduce immediate postoperative pain and opioid requirements compared with placebo and these differences could be clinically meaningful."

Several authors disclosed financial ties to the biopharmaceutical industry, including Mallinkrodt Pharma, which funded the study.

Abstract/Full Text
Editorial

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

24-Hour Primary Care Clinics Would Improve Continuity of Care

24-Hour Primary Care Clinics Would Improve Continuity of ...

Model involving multiple doctors working shifts in their own clinic offers many benefits

Repeat BP Reading Needed in Children With Initial High Result

Repeat BP Reading Needed in Children With Initial ...

Based on initial reading, more than half of children would have incorrect classification

Brochure Can Improve Opioid Disposal Rates After Surgery

Brochure Can Improve Opioid Disposal Rates After Surgery

Patients more likely to dispose of unused opioids after getting information and recommendations

is free, fast, and customized just for you!

Already a member?

Sign In Now »