PERFI Feasible for In Vivo Imaging of Nonmelanoma Skin Cancer

This article originally appeared here.
Share this content:
PERFI Feasible for In Vivo Imaging of Nonmelanoma Skin Cancer
PERFI Feasible for In Vivo Imaging of Nonmelanoma Skin Cancer

FRIDAY, June 2, 2017 (HealthDay News) -- Polarization-enhanced reflectance and fluorescence imaging (PERFI) is feasible for in vivo intraoperative imaging of nonmelanoma skin cancer (NMSC), according to a study published online May 25 in Lasers in Surgery and Medicine.

Anna N. Yaroslavsky, Ph.D., from the University of Massachusetts Lowell, and colleagues recruited eight patients with biopsy-confirmed NMSC scheduled for Mohs micrographic surgery. Following dilution of sterile methylene blue (MB) in anesthetic solution, it was infused into the peritumoral space; digital photographs of the lesions were taken. The surgical bed was re-imaged after Mohs surgery. Each excision was also imaged ex vivo and underwent processing for histopathology.

The researchers found that MB injection was well tolerated. Transient blue staining of the treated area was observed; in all of the patients, it disappeared completely within one week. The contrast agent MB was preferentially retained in the tumor in all subjects. There was good correlation for ex vivo images with histopathology. The tumor margins were qualitatively delineated in in vivo images.

"The results of our pilot trial indicate that PERFI may be useful for accurate and rapid delineation of NMSC during surgery," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

FDA Approves Palynziq for Phenylketonuria

FDA Approves Palynziq for Phenylketonuria

Drug is a novel enzyme therapy for adult patients with PKU with uncontrolled blood Phe concentrations

Increase in Tx Candidates With 2017 Hypertension Guidelines

Increase in Tx Candidates With 2017 Hypertension Guidelines

Increase in proportion of adults recommended for treatment; estimated decrease in CVD events, deaths