Penile Microbiome May Be Risk Factor for HIV in Men

This article originally appeared here.
Share this content:
Penile Microbiome May Be Risk Factor for HIV in Men
Penile Microbiome May Be Risk Factor for HIV in Men

WEDNESDAY, July 26, 2017 (HealthDay News) -- The microbiome of the area on the penis located under the foreskin in uncircumcised straight men has been linked to increased risk for contracting HIV, according to a study published in the July 25 issue of mBio.

Cindy Liu, M.D., M.P.H., Ph.D., of the George Washington University Milken Institute School of Public Health in Washington, D.C., and colleagues spent two years tracking 182 men who lived in the town of Rakai in Uganda. During that time, 46 men became infected with HIV.

After analyzing bacterial samples swabbed from under the foreskin of all the participants, the study team concluded that those who had higher quantities of four anaerobic bacteria also had a significantly higher risk for contracting HIV. The team determined that whenever these bacteria increase in quantity by a factor of 10, HIV risk appears to rise by as much as 63 percent.

We found that "having higher levels of penile anaerobes was also associated with higher production of immune factors that recruit HIV target cells to the foreskin, suggesting that anaerobes may modify HIV risk by triggering inflammation," the authors write. "These anaerobes are known to be shared by heterosexual partners and are associated with HIV risk in women. Therefore, penile anaerobes may be a sexually transmissible risk factor for HIV, and modifying the penile microbiome could potentially reduce HIV acquisition in both men and women."

Abstract
Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »