Pattern of Stressor-Evoked Brain Activity Can Predict BP Reactivity

Share this content:
Pattern of Stressor-Evoked Brain Activity Can Predict BP Reactivity
Pattern of Stressor-Evoked Brain Activity Can Predict BP Reactivity

WEDNESDAY, Aug. 23, 2017 (HealthDay News) -- A multivariate pattern of stressor-evoked brain activity can predict individual differences in blood pressure (BP) reactivity, according to a study published online Aug. 23 in the Journal of the American Heart Association.

Peter J. Gianaros, Ph.D., from the University of Pittsburgh, and colleagues enrolled 310 community-dwelling adults who underwent functional magnetic resonance imaging with concurrent BP monitoring while completing a standardized battery of stressor tasks. The authors sought to examine whether a pattern of stressor-evoked brain activity could reliably predict individual differences in BP reactivity.

The researchers found that the battery evoked an increase in systolic and diastolic BP relative to a non-stressor baseline period across individuals. In a training subsample (206 participants), a multivariate pattern of stressor-evoked functional magnetic resonance imaging activity was identified using cross-validation and machine learning approaches, including dimensionality reduction and linear shrinkage models. In an independent subsample used for testing and replication (104 individuals), this pattern reliably predicted both systolic and diastolic BP reactivity. Brain areas that were strongly predictive included those implicated in psychological stressor processing and cardiovascular responding through autonomic pathways, such as the medial prefrontal cortex, anterior cingulate cortex, and insula.

"A novel multivariate pattern of stressor-evoked brain activity may comprise a phenotype that partly accounts for individual differences in BP reactivity, a stress-related cardiovascular risk factor," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Opioid Rx, Dosing Often Excessive in Dialysis Patients

Opioid Rx, Dosing Often Excessive in Dialysis Patients

High-risk dialysis population also subject to the risks of long-term opioid use

Nonadherence to Statins  ACEIs/ARBs Risky Post MI

Nonadherence to Statins + ACEIs/ARBs Risky Post MI

Adherence to beta-blockers may not be as beneficial to patients after myocardial infarction

Pulse Ox  Auscultation Reliable for Congenital Heart Screening

Pulse Ox + Auscultation Reliable for Congenital Heart ...

The method significantly improves detection rate of major CHD in newborns

is free, fast, and customized just for you!

Already a member?

Sign In Now »