Patients With Polyneuropathy More Often Receive Opioids

Share this content:
Patients With Polyneuropathy More Often Receive Opioids
Patients With Polyneuropathy More Often Receive Opioids

TUESDAY, May 23, 2017 (HealthDay News) -- Polyneuropathy is associated with increased likelihood of receiving long-term opioids, although long-term opioids do not improve functional status markers, according to a study published online May 22 in JAMA Neurology.

E. Matthew Hoffman, D.O., Ph.D., from the Mayo Clinic in Rochester, Minn., and colleagues conducted a retrospective population-based cohort study of prescriptions given to patients with polyneuropathy and controls in ambulatory practice (2,892 and 14,435 patients, respectively). The authors examined long-term opioid therapy, defined by one or multiple consecutive opioid prescriptions resulting in 90 days or more of opioid use.

The researchers found that patients with polyneuropathy received long-term opioids more often than controls (18.8 versus 5.4 percent). After adjustment for medical comorbidity, patients with polyneuropathy who were receiving long-term opioids had multiple functional status markers that were modestly poorer, including increased reliance on gait aids (adjusted odds ratio, 1.9); there was no improvement in functional status markers with long-term use of opioids. Among patients with polyneuropathy receiving long-term opioids, adverse outcomes were more common, including depression, opioid dependence, and opioid overdose (adjusted hazard ratios, 1.53, 2.85, and 5.12, respectively).

"Polyneuropathy increased the likelihood of long-term opioid therapy," the authors write. "However, long-term opioid therapy did not improve functional status but rather was associated with a higher risk of subsequent opioid dependency and overdose."

Abstract/Full Text
Editorial

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

CDC Launches Campaign to Fight Prescription Opioid Epidemic

CDC Launches Campaign to Fight Prescription Opioid Epidemic

Rx Awareness campaign uses testimonials to educate the public, increase awareness about risks

Liraglutide Linked to Reduction in VAT, Improvement in -Index

Liraglutide Linked to Reduction in VAT, Improvement in ...

Significant improvement in IGF-II serum levels with liraglutide for obese with prediabetes, early T2DM

Nut Consumption Linked to Nutritionally Rich Food Intake

Nut Consumption Linked to Nutritionally Rich Food Intake

Nut consumers eat more fruits, vegetables, less red meat, and have lower BMI than non-nut consumers

is free, fast, and customized just for you!

Already a member?

Sign In Now »