PAS: Buprenorphine Beneficial in Neonatal Abstinence Syndrome

This article originally appeared here.
Share this content:
PAS: Buprenorphine Beneficial in Neonatal Abstinence Syndrome
PAS: Buprenorphine Beneficial in Neonatal Abstinence Syndrome

FRIDAY, May 5, 2017 (HealthDay News) -- Sublingual buprenorphine is associated with shorter duration of treatment than oral morphine for infants with neonatal abstinence syndrome, according to a study published online May 4 in the New England Journal of Medicine. The research was published to coincide with the annual meeting of the Pediatric Academic Societies, held from May 6 to 9 in San Francisco.

Walter K. Kraft, M.D., from the Sidney Kimmel Medical College at Thomas Jefferson University in Philadelphia, and colleagues conducted a double-blind, double-dummy clinical trial involving 63 term infants who had been exposed to opioids in utero and had signs of neonatal abstinence syndrome. The infants were randomized to receive sublingual buprenorphine or oral morphine. Adjunctive phenobarbital was used to treat infants with symptoms that were not controlled with the maximum dose of opioid.

The researchers found that, compared with morphine, buprenorphine correlated with significantly shorter median duration of treatment (15 versus 28 days) and median length of hospital stay (21 versus 33 days) (both P < 0.001). Adjunctive phenobarbital was administered to 15 and 23 percent of infants in the buprenorphine and morphine groups, respectively (P = 0.36). Similar rates of adverse events were seen in the groups.

"Among infants with the neonatal abstinence syndrome, treatment with sublingual buprenorphine resulted in a shorter duration of treatment and shorter length of hospital stay than treatment with oral morphine, with similar rates of adverse events," the authors write.

Abstract
Full Text
More Information

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

24-Hour Primary Care Clinics Would Improve Continuity of Care

24-Hour Primary Care Clinics Would Improve Continuity of ...

Model involving multiple doctors working shifts in their own clinic offers many benefits

Repeat BP Reading Needed in Children With Initial High Result

Repeat BP Reading Needed in Children With Initial ...

Based on initial reading, more than half of children would have incorrect classification

Brochure Can Improve Opioid Disposal Rates After Surgery

Brochure Can Improve Opioid Disposal Rates After Surgery

Patients more likely to dispose of unused opioids after getting information and recommendations

is free, fast, and customized just for you!

Already a member?

Sign In Now »