Parathyroid Hormone Linked to Arterial Stiffness in T1DM

Share this content:
Parathyroid Hormone Linked to Arterial Stiffness in T1DM
Parathyroid Hormone Linked to Arterial Stiffness in T1DM

WEDNESDAY, Jan. 11, 2017 (HealthDay News) -- In individuals with type 1 diabetes, parathyroid hormone (PTH) is associated with arterial stiffness, even after adjustment for multiple confounding variables, according to research published online Jan. 6 in Diabetes Care.

Emilie H. Zobel, M.D., from the Steno Diabetes Center in Gentofte, Denmark, and colleagues examined the correlation between arterial stiffness, evaluated by carotid-femoral pulse wave velocity (cfPWV), and bone mass density in a well-characterized cohort of 347 individuals with type 1 diabetes.

The researchers found that bone mineral density, all clinical bone markers, and markers of mineral metabolism, except calcium, phosphorus, and Dickkopf 1, correlated with cfPWV in unadjusted analyses (P ≤ 0.041). The level of bone mineral density, the clinical bone marker PTH, and the marker of bone mineral metabolism sclerostin correlated with cfPWV after adjustment for age, sex, and mean arterial pressure (P ≤ 0.027). PTH remained positively associated with cfPWV after further adjustment for additional risk factors, including hemoglobin A1c, total cholesterol, body mass index, antihypertensive treatment, urinary albumin excretion rate, estimated glomerular filtration rate, and smoking (P = 0.014).

"Our findings highlight PTH as a potential mediator for the cross talk between bone and vascular disease," the authors write. "However, our findings need validation, and prospective studies investigating the relationship between PTH and cardiovascular outcome in type 1 diabetes are warranted."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

NTproBNP Levels Are Significantly Lower in Blacks

NTproBNP Levels Are Significantly Lower in Blacks

Higher NTproBNP levels linked to increased risk of death; this association did not differ by race

Data May Weigh on Pros/Cons of Expanded Care Optometry

Data May Weigh on Pros/Cons of Expanded Care ...

Majority of residents in Kentucky, Oklahoma, New Mexico live within 30 minutes of ophthalmologist

Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

Gaps Seen Between Hearing Loss, Receipt of Medical ...

About 20.6 percent of those with hearing less than excellent/good had visited doctor for hearing issues

is free, fast, and customized just for you!

Already a member?

Sign In Now »