Ozanimod Shows Promise for Ulcerative Colitis Remission

Share this content:
Ozanimod Shows Promise for Ulcerative Colitis Remission
Ozanimod Shows Promise for Ulcerative Colitis Remission

WEDNESDAY, May 4, 2016 (HealthDay News) -- A daily dose of ozanimod (1 mg) shows potentially positive results for clinical remission of ulcerative colitis, compared to placebo, according to a preliminary study published in the May 5 issue of the New England Journal of Medicine.

William J. Sandborn, M.D., from the University of California in San Diego, and colleagues conducted a double-blind, placebo-controlled phase 2 trial of ozanimod in 197 adults with moderate-to-severe ulcerative colitis. Patients were randomly assigned (1:1:1) to receive ozanimod at a dose of 0.5 mg, 1 mg, or placebo daily for up to 32 weeks.

The researchers found that clinical remission at eight weeks (primary outcome) occurred in 16 percent of the patients who received 1 mg of ozanimod and in 14 percent of those who received 0.5 mg of ozanimod, compared to 6 percent of those receiving placebo (P = 0.048 and 0.14, respectively, for the two doses versus placebo). The rate of clinical remission at week 32 was 21 percent in the 1-mg ozanimod group, 26 percent in the 0.5-mg ozanimod group, and 6 percent in the placebo group; the corresponding rates of clinical response (decrease in Mayo Clinic score of ≥3 points and ≥30 percent and decrease in rectal-bleeding subscore of ≥1 point or a subscore ≤1) were 51, 35, and 20 percent. Anemia and headache were the most common adverse events.

"The trial was not large enough or of sufficiently long duration to establish clinical efficacy or assess safety," the authors write.

Several authors disclosed financial ties to Receptos, which funded the study and is now a wholly owned subsidiary of Celgene, the manufacturer of ozanimod.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »