Oxytocin Ups Feeding, Social Skills in Infants With Prader-Willi

Share this content:
Oxytocin Ups Feeding, Social Skills in Infants With Prader-Willi
Oxytocin Ups Feeding, Social Skills in Infants With Prader-Willi

WEDNESDAY, Jan. 18, 2017 (HealthDay News) -- For infants with Prader-Willi syndrome (PWS), oxytocin (OXT) administration is associated with improvement in feeding and social skills, according to a study published online Jan. 18 in Pediatrics.

Maïthé Tauber, M.D., from the Hôpital des Enfants in Toulouse, France, and colleagues conducted a phase 2 dose escalating study of a seven-day course of intranasal OXT administration in 18 infants with PWS under 6 months old. Infants received 4 IU of OXT every other day, daily, or twice daily.

The researchers found that there were no reports of adverse events, and no dose effect. At baseline, all infants had abnormal sucking, as measured by the Neonatal Oral-Motor Scale; sucking was normalized in 88 percent after treatment. There were significant decreases in the scores of Neonatal Oral-Motor Scale, from 16 to 9 (P < 0.001), and in videofluoroscopy of swallowing, from 18 to 12.5 (P < 0.001). There were significant improvements in Clinical Global Impression scale scores, social withdrawal behavior, and mother-infant interactions. A significant increase was seen in acylated ghrelin and connectivity of the right superior orbitofrontal network on functional magnetic resonance imaging, which was associated with sucking and behavior changes.

"OXT is well tolerated in infants with PWS and improves feeding and social skills," the authors write. "These results open perspectives for early treatment in neurodevelopment diseases with feeding problems."

Two authors obtained a patent based on the results of their studies regarding administration of oxytocin in Magel2 KO mouse and adults with Prader-Willi syndrome.

Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

FDA Approves First Generic Under-the-Tongue Suboxone

FDA Approves First Generic Under-the-Tongue Suboxone

May only be prescribed by Drug Addiction Treatment Act-certified prescribers

Kellogg's Honey Smacks Cereal Recalled Due to Salmonella Risk

Kellogg's Honey Smacks Cereal Recalled Due to <i>Salmonella</i> ...

Twenty-four people have been hospitalized, but no deaths have been reported

Portable Music Player Use Linked to Hearing Loss in Children

Portable Music Player Use Linked to Hearing Loss ...

Increased odds of high-frequency hearing loss with portable music player use

is free, fast, and customized just for you!




Already a member?

Sign In Now »