Outcomes Similar for Rx Dosing Protocols in Ectopic Pregnancy

Share this content:
Outcomes Similar for Rx Dosing Protocols in Ectopic Pregnancy
Outcomes Similar for Rx Dosing Protocols in Ectopic Pregnancy

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- For ectopic pregnancy, outcomes are similar with a single- and double-dose methotrexate protocol, according to a study published in the November issue of the American Journal of Obstetrics & Gynecology.

Michelle C. Mergenthal, M.D., from the University of Pennsylvania in Philadelphia, and colleagues conducted a multicenter cohort study involving clinical data from women who received medical management for ectopic pregnancy. The authors assessed the rates of human chorionic gonadotropin change and successful pregnancy resolution.

Of the 162 ectopic pregnancies included in the final analysis, 70 percent were treated with single-dose methotrexate and 30 percent with the two-dose protocol. The researchers found that site, race, ethnicity, and reported pain level correlated with differential protocol allocation. Initial human chorionic gonadotropin levels were similar in either protocol, but from day zero to day seven the mean rate of decline of human chorionic gonadotropin was significantly more rapid with the single-dose versus the two-dose protocol (mean change −31.3 percent versus −10.4 percent; P = 0.037). There were no significant differences in success rate or time to resolution for the two protocols.

"In a racially and geographically diverse group of women, the single- and double-dose methotrexate protocols had comparable outcomes," the authors write. "The more rapid human chorionic gonadotropin initial decline in the single-dose group suggested these patients were probably at lower risk for ectopic rupture than those getting the two-dose protocol."

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

SABCS: Artificial Intelligence May Aid Doctors in Breast Cancer Care

SABCS: Artificial Intelligence May Aid Doctors in Breast ...

'Watson Oncology' agreed with doctors 90 percent of the time in many cases, researchers find

SABCS: Scalp-Cooling System Can Reduce Chemo-Related Hair Loss

SABCS: Scalp-Cooling System Can Reduce Chemo-Related Hair Loss

Devices reduce blood flow to hair follicles during chemotherapy treatments

SABCS: Aromatase Inhibitors Tied to Reduced Endothelial Function

SABCS: Aromatase Inhibitors Tied to Reduced Endothelial Function

Women on aromatase inhibitors exhibit less elasticity in their blood vessels

is free, fast, and customized just for you!

Already a member?

Sign In Now »