Orthostatic Hypotension May Increase Risk of Dementia

Share this content:
Orthostatic Hypotension May Increase Risk of Dementia
Orthostatic Hypotension May Increase Risk of Dementia

WEDNESDAY, Oct. 12, 2016 (HealthDay News) -- There is an association between orthostatic hypotension and an increased risk for dementia, according to a new study published online Oct. 11 in PLOS Medicine.

Frank Wolters, M.D., of the Erasmus Medical Center in Rotterdam, Netherlands, and colleagues analyzed 24 years of data from 6,204 people.

The researchers found that orthostatic hypotension was associated with a 15 percent increase in long-term risk of dementia, including Alzheimer's disease. Furthermore, the risk was particularly increased when the orthostatic blood pressure drops were not compensated for by a sufficient increase in heart rate.

"The most apparent explanation for our findings is that orthostatic hypotension causes brain damage due to recurrent transient cerebral hypoperfusion," the authors write. "Autonomic nervous system function is responsible for maintaining continuous cerebral perfusion, together with local vasoreactivity, which has previously been associated with the risk of dementia in the general population. Brief episodes of hypoperfusion elicited by sudden blood pressure drops may lead to hypoxia, with detrimental effects on brain tissue via, for instance, neuroinflammation and oxidative stress."

Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

FDA Warns Against Children Taking Codeine, Tramadol

FDA Warns Against Children Taking Codeine, Tramadol

Agency strengthens warning labels on these medications to address dangers

Trump Administration Offers Grants to Fight Opioid Crisis

Trump Administration Offers Grants to Fight Opioid Crisis

Money to be used to train health professionals, foster prescription drug monitoring programs

NYC to Raise Cigarette Prices to Highest in the United States

NYC to Raise Cigarette Prices to Highest in ...

Price of pack to jump from $10.50 to $13.00

is free, fast, and customized just for you!

Already a member?

Sign In Now »