Oral Microbiome Composition Linked to Esophageal Cancer Risk

This article originally appeared here.
Share this content:
Oral Microbiome Composition Linked to Esophageal Cancer Risk
Oral Microbiome Composition Linked to Esophageal Cancer Risk

MONDAY, Dec. 4, 2017 (HealthDay News) -- Oral microbiome composition is associated with the risk of esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), according to a study published online Dec. 1 in Cancer Research.

Brandilyn A. Peters, Ph.D., from the NYU School of Medicine in New York City, and colleagues examined the correlation between oral microbiota with EAC and ESCC risk in a prospective study nested in two cohorts. 16S rRNA gene sequencing was used to assess oral bacteria in prediagnostic mouthwash samples from 81 cases with EAC and 160 matched controls and from 25 cases of ESCC and 50 matched controls.

The researchers found that the periodontal pathogen Tannerella forsythia correlated with increased risk of EAC. Lower EAC risk was seen in association with depletion of the commensal genus Neisseria and the species Streptococcus pneumoniae. There was also a correlation for bacterial biosynthesis of carotenoids with protection against EAC. There was a trend toward increased risk of ESCC with abundance of the periodontal pathogen Porphyromonas gingivalis.

"Overall, our findings have potential implications for the early detection and prevention of EAC and ESCC," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

ASH: Anti-CD19 CAR T-Cell Tx Beneficial in B-Cell Lymphomas

ASH: Anti-CD19 CAR T-Cell Tx Beneficial in B-Cell ...

Second study shows benefit in relapsed or refractory B-cell lymphoma, follicular lymphoma

ASH: AAVD Beats ABVD for Advanced Hodgkin's Lymphoma

ASH: A+AVD Beats ABVD for Advanced Hodgkin's Lymphoma

Lower combined risk of progression, death, or noncomplete response with A+AVD

ASH: High-Dose Gene Transfer Beneficial in Severe Hemophilia A

ASH: High-Dose Gene Transfer Beneficial in Severe Hemophilia ...

Factor VIII gene transfer tied to sustained normalization of factor VIII activity levels

is free, fast, and customized just for you!

Already a member?

Sign In Now »