Oral Antibiotics Cut Risk of SSI in Colorectal CA Resection

Share this content:
Oral Antibiotics Cut Risk of SSI in Colorectal CA Resection
Oral Antibiotics Cut Risk of SSI in Colorectal CA Resection

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- For patients undergoing left colon and rectal cancer resections, the addition of oral antibiotics to mechanical bowel preparation (MBP) is associated with a reduced rate of surgical site infections (SSIs), according to a study published online Oct. 18 in JAMA Surgery.

Elaine Vo, M.D., from Baylor College of Medicine in Houston, and colleagues compared patients undergoing left colon and rectal cancer resections receiving MBP and oral antibiotics (40 patients) and MBP without oral antibiotics (49 patients) to examine the association with occurrence of SSIs.

The researchers found that patients who received oral antibiotics and MBP had a lower overall SSI rate than those who received MBP only (8 versus 27 percent; P = 0.03). No deep or organ space SSIs or anastomotic leaks were seen in patients who received oral antibiotics and MBP, compared with 18 and 10 percent among patients who received MBP only (P = 0.004 and P = 0.06, respectively). Independent associations were seen for oral antibiotics and MBP and for minimally invasive surgery with reduced odds of SSI (odds ratios, 0.11 [95 percent confidence interval, 0.02 to 0.86; P = 0.04] and 0.22 [95 percent confidence interval, 0.05 to 0.89; P = 0.03]).

"The combination of oral antibiotics and MBP is associated with a significant decrease in the rate of SSIs and should be considered for patients undergoing elective left colon and rectal cancer resections," the authors write.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Medicaid Expansion Ups Preemptive Listing for Kidney Transplant

Medicaid Expansion Ups Preemptive Listing for Kidney Transplant

From pre- to post-expansion period, 59 percent relative increase in Medicaid-covered preemptive listings

BCG Vaccine Tied to Reduced Hyperglycemia in Type 1 Diabetes

BCG Vaccine Tied to Reduced Hyperglycemia in Type ...

Systemic shift in glucose metabolism from oxidative phosphorylation to aerobic glycolysis

Many Physicians Not Prepared for End-of-Life Talks With Patients

Many Physicians Not Prepared for End-of-Life Talks With ...

Additional training, reimbursement may foster these critical conversations, authors say

is free, fast, and customized just for you!




Already a member?

Sign In Now »