Open-Label Placebos Seem to Have Positive Clinical Effect

This article originally appeared here.
Share this content:
Open-Label Placebos Seem to Have Positive Clinical Effect
Open-Label Placebos Seem to Have Positive Clinical Effect

MONDAY, May 8, 2017 (HealthDay News) -- Compared with no treatment, open-label placebos seem to have a positive clinical effect, according to a review published online April 27 in the Journal of Evidence-Based Medicine.

James E.G. Charlesworth, Ph.D., from the University of Oxford in the United Kingdom, and colleagues conducted a systematic review and meta-analysis to examine the clinical efficacy of open-label placebos versus no treatment. Five trials, with 260 participants, met the inclusion criteria.

The clinical conditions assessed in the trials included irritable bowel syndrome, depression, allergic rhinitis, back pain, and attention deficit hyperactivity disorder. The researchers found that there was a moderate risk of bias in the trials. The effect of non-deceptive placebos was positive (standardized mean difference, 0.88; 95 percent confidence interval, 0.62 to 1.14; P < 0.00001; I² = 1 percent).

"Open-label placebos appear to have positive clinical effects compared to no treatment. Caution is warranted when interpreting these results due the limited number of trials identified, lack of assessor blinding, and the fact that positive messages were included alongside open-label placebos," the authors write. "Larger definitive trials are now warranted to explore the potential patient benefit of open-label placebos, to investigate the relative contributions of positive suggestions, and ethical implications."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Surveillance Frequency Doesn't Cut Mortality in Colorectal Cancer

Surveillance Frequency Doesn't Cut Mortality in Colorectal Cancer

And, intensity of imaging surveillance not linked to time to detection of colorectal cancer recurrence

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower RTI

Procalcitonin Assay Doesn't Cut Antibiotic Use in Lower ...

Provision of assay doesn't result in less antibiotic use for suspected lower respiratory tract infection

Preventing Child Maltreatment Not Yet Feasible in Primary Care

Preventing Child Maltreatment Not Yet Feasible in Primary ...

USPSTF says evidence inadequate for primary care interventions to prevent child maltreatment

is free, fast, and customized just for you!

Already a member?

Sign In Now »