On-Pump CABG Leads to Higher Rates of Five-Year Survival

Share this content:
On-Pump CABG Leads to Higher Rates of Five-Year Survival
On-Pump CABG Leads to Higher Rates of Five-Year Survival

THURSDAY, Aug. 17, 2017 (HealthDay News) -- Five years after coronary-artery bypass grafting (CABG) surgery, patients whose operation was performed with cardiopulmonary bypass (on pump) lived longer than those whose surgeons performed the procedure without cardiopulmonary bypass (off pump), according to a report published in the Aug. 17 issue of the New England Journal of Medicine.

Researchers looked at the five-year outcomes of patients who had CABG as part of the U.S. Veterans Affairs trial of on-pump versus off-pump operations done from February 2002 through June 2007. In this trial, 2,203 patients from 18 VA centers were randomly selected to receive either on-pump or off-pump CABG. They were assessed a year after their operation and then at five years. Specifically, the researchers looked for adverse cardiovascular events, including death from any cause, repeat revascularization, and nonfatal myocardial infarction.

The investigators found that after a year, more patients who had an off-pump operation died or needed new procedures than patients who had on-pump surgery. Five years after surgery, the mortality rate among those in the off-pump group was 15.2 percent, compared with 11.9 percent among those who had on-pump surgery (relative risk, 1.28; 95 percent confidence interval, 1.03 to 1.58; P = 0.02). In addition, more patients who had off-pump surgery had major adverse cardiovascular events than those who had on-pump operations -- 31.0 versus 27.1 percent (relative risk, 1.14; 95 percent confidence interval, 1.00 to 1.30; P = 0.046). No differences were observed for rates of nonfatal myocardial infarction (P = 0.05), death from cardiac causes (P = 0.29), repeat revascularization (P = 0.39), or repeat CABG (P = 0.02).

"In this randomized trial, off-pump CABG led to lower rates of five-year survival and event-free survival than on-pump CABG," the authors write.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

Structural Findings of Acute Solar Retinopathy Described

Structural Findings of Acute Solar Retinopathy Described

Patient in case study presented three days after viewing solar eclipse

Telomere Fusions Predict Dysplasia, Invasive Pancreatic CA

Telomere Fusions Predict Dysplasia, Invasive Pancreatic CA

Telomere fusions are detected in later stages of intraductal papillary mucinous neoplasm progression

Prenatal Sugar Intake May Increase Asthma Risk in Offspring

Prenatal Sugar Intake May Increase Asthma Risk in ...

Higher intake during pregnancy, in early childhood associated with childhood asthma development

is free, fast, and customized just for you!

Already a member?

Sign In Now »