Ocular Histopathology Features Seen With Congenital Zika

Share this content:
Ocular Histopathology Features Seen With Congenital Zika
Ocular Histopathology Features Seen With Congenital Zika

MONDAY, Sept. 25, 2017 (HealthDay News) -- Certain ocular histopathologic features are consistently found in fetuses with congenital Zika syndrome (CZS), according to a study published online Sept. 21 in JAMA Ophthalmology.

Maria P. Fernandez, M.D., from the University of Miami, and colleagues analyzed ocular tissue samples from four deceased fetuses (21.5 to 29 weeks of gestation) with a diagnosis of CZS. Analysis included microscopic examination and immunostaining using a Zika virus (ZIKV) NS2B protein antibody.

The researchers found that the four eyes manifested with pupillary membranes, immature anterior chamber angles, loss of pigment and thinning of the retinal pigment epithelium, choroidal thinning, undifferentiated nuclear layers of the retina, and a perivascular inflammatory infiltrate within the choroid. There was atrophy in the optic nerve in two of the eyes. Expression of ZIKV antigen was present in the iris of three cases, the neural retina and choroid in one case, and in the optic nerve in one case.

"Loss of retinal pigment epithelium, the presence of a thin choroid, a perivascular choroidal inflammatory infiltrate, and atrophic changes within the optic nerve were consistently present," the authors write.

Abstract/Full Text

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

Automated Central System Offers Time Savings for Pharmacists

Automated Central System Offers Time Savings for Pharmacists

Cart-fill process using new automated system is more efficient, frees up time for other roles

Therapeutic Horseback Riding Can Help Alleviate PTSD in Veterans

Therapeutic Horseback Riding Can Help Alleviate PTSD in ...

Study found statistically and clinically significant reduction in PTSD scores after six weeks of THR

Bariatric Surgery Linked to Discontinuing Diabetes Meds

Bariatric Surgery Linked to Discontinuing Diabetes Meds

Six-year antidiabetes treatment initiation rate also much lower after bariatric surgery

is free, fast, and customized just for you!

Already a member?

Sign In Now »