October 2017 Briefing - Pharmacy

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for October 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Fentanyl or Analogs Tied to More Than Half of All Opioid Deaths

TUESDAY, Oct. 31, 2017 (HealthDay News) -- Fentanyl was involved in more than half of opioid overdose deaths reported in the second half of 2016, according to a study published online Oct. 27 in Morbidity and Mortality Weekly Report.

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Calquence Approved for Mantle Cell Lymphoma

TUESDAY, Oct. 31, 2017 (HealthDay News) -- Calquence (acalabrutinib) has been approved by the U.S. Food and Drug Administration to treat adults with mantle cell lymphoma.

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Children of Immigrants Less Likely to be Up-to-Date on Shots

TUEDAY, Oct. 31, 2017 (HealthDay News) -- Children up to age 36 months with at least one foreign-born parent are less likely to be up-to-date on recommended vaccinations, according to a study published online Oct. 26 in Morbidity and Mortality Weekly Report.

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Ohio Upholds Law Requiring HIV-Infected to Tell Sex Partners

TUESDAY, Oct. 31, 2017 (HealthDay News) -- The Ohio Supreme Court has unanimously upheld the constitutionality of a law requiring HIV-infected individuals to tell their sexual partners of their status before having sex, according to a report published by the Associated Press.

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PFA-100-Measured Aspirin Resistance Linked to CV Events

TUESDAY, Oct. 31, 2017 (HealthDay News) -- Aspirin resistance, measured using the Platelet Function Analyzer (PFA)-100 system, is associated with cardiovascular events in aspirin-treated patients, according to a study published online Oct. 21 in the Journal of Clinical Pharmacy and Therapeutics.

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Diabetes of Exocrine Pancreas Often Classified as T2DM

MONDAY, Oct. 30, 2017 (HealthDay News) -- Diabetes that follows pancreatic disease is frequently classified as type 2 diabetes but is associated with worse glycemic control and higher use of insulin within five years than type 2 diabetes, according to a study published in the August issue of Diabetes Care.

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Maternal Use of Acetaminophen Linked to ADHD in Offspring

MONDAY, Oct. 30, 2017 (HealthDay News) -- Maternal use of acetaminophen in pregnancy is associated with attention-deficit/hyperactivity disorder (ADHD) in offspring, according to a study published online Oct. 30 in Pediatrics.

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Rate of Approval for PCSK9i Therapy 47 Percent

MONDAY, Oct. 30, 2017 (HealthDay News) -- A combination of clinical factors and payer type increase the likelihood of approval for proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) treatment, and rates of approval are low overall, according to a study published online Oct. 30 in Circulation.

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Incretin Tied to Better Outcomes in NOCS-Diabetes

FRIDAY, Oct. 27, 2017 (HealthDay News) -- Incretin treatment appears to improve non-ST-elevation myocardial infarction (NSTEMI) outcomes in patients with type 2 diabetes and non-obstructive coronary artery stenosis (NOCS), according to a study published online Sept. 26 in Diabetes, Obesity and Metabolism.

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Multidisciplinary Model Cuts Treatment Delay in Head, Neck CA

FRIDAY, Oct. 27, 2017 (HealthDay News) -- For patients with head and neck cancer, a multidisciplinary head and neck clinic model is associated with reduced treatment delay, according to a study published online Oct. 26 in JAMA Otolaryngology -- Head & Neck Surgery.

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70-Gene Signature Impacts Treatment Decisions in Breast CA

FRIDAY, Oct. 27, 2017 (HealthDay News) -- The 70-gene signature (GS) assay affects treatment decisions among physicians treating patients identified as being at intermediate risk with the 21-gene assay (21-GA), according to a study published online Oct. 26 in JAMA Oncology.

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Probiotics Linked to Weight Loss in Obese, Overweight

FRIDAY, Oct. 27, 2017 (HealthDay News) -- Short-term probiotics are associated with reductions in body weight, body mass index (BMI), and fat percentage in overweight or obese subjects, according to research published online Oct. 18 in Obesity Reviews.

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HER3 Linked to Improved Survival With Panitumumab

THURSDAY, Oct. 26, 2017 (HealthDay News) -- Higher HER3 expression is associated with improved survival with the addition of panitumumab treatment for patients with RAS wild-type (wt) advanced colorectal cancer, according to a study published online Oct. 26 in JAMA Oncology.

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Many Teenagers Unaware That Adderall Is an Amphetamine

THURSDAY, Oct. 26, 2017 (HealthDay News) -- Adolescents appear to underreport their nonmedical amphetamine use, which may be in part due to lacking awareness that Adderall is an amphetamine, according to a study published online Oct. 23 in Drug and Alcohol Dependence.

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Panel Recommends New Zoster Vaccine as First-Line Treatment

THURSDAY, Oct. 26, 2017 (HealthDay News) -- In a close 8-7 vote, the Advisory Committee on Immunization Practices recommended that Shingrix be chosen over Zostavax as the herpes zoster vaccine of choice in adults aged 50 and older, the Washington Post reported.

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Gifts From Pharma Companies Influence Prescribing Behavior

THURSDAY, Oct. 26, 2017 (HealthDay News) -- Receipt of gifts from pharmaceutical companies is associated with more prescriptions per patient and more costly prescriptions, according to a study published online Oct. 25 in PLOS One.

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Chewing Ticagrelor Loading Dose May Be Beneficial in STEMI

THURSDAY, Oct. 26, 2017 (HealthDay News) -- For patients with ST-segment elevation myocardial infarction (STEMI), chewing a loading dose (LD) of ticagrelor facilitates better early platelet inhibition, according to a study published online Oct. 25 in JAMA Cardiology.

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HIV Drug Resistance Is Threatening Gains of Treatment

THURSDAY, Oct. 26, 2017 (HealthDay News) -- Resistance to antiretroviral therapy (ART) is threatening the recent gains of treatment in the rate of new HIV infections, according to a perspective article published online Oct. 25 in the New England Journal of Medicine.

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Secondary Prevention Meds Often Not Started Post-AMI in Seniors

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Thirty-seven percent of older nursing home (NH) residents do not initiate secondary prevention medications after acute myocardial infarction (AMI), according to a study published online Oct. 17 in the Journal of the American Geriatrics Society.

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Vitamin D Supplements Improve Markers of Bone Turnover in CKD

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- For patients with chronic kidney disease (CKD), cholecalciferol supplementation can correct vitamin D deficiency and improve markers of bone turnover, according to a study published online Oct. 17 in the Journal of Bone and Mineral Research.

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Mechanism ID'd for Chemo-Related Peripheral Neuropathy

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Researchers may have uncovered the mechanism for chemotherapy-induced peripheral neuropathy (CIPN) related to paclitaxel, according to a study published online Oct. 11 in Neuron.

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Module Developed to Improve Adult Vaccination Rates

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- A module has been developed to help health care professionals improve vaccination rates among adults, according to an article published by the American Medical Association (AMA).

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New Clinical Practice Guideline for Management of T2DM

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Management of type 2 diabetes should include shared decision making, and patients should be offered individualized diabetes self-management education and glycemic management plans, according to a summary of a clinical practice guideline published online Oct. 23 in the Annals of Internal Medicine.

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Undiagnosed Diabetes Accounts for Small Portion of Diabetes

WEDNESDAY, Oct. 25, 2017 (HealthDay News) -- Undiagnosed diabetes accounts for a relatively small proportion of the total diabetes population in the United States, according to a study published online Oct. 23 in the Annals of Internal Medicine.

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DEA Taking Back Unwanted Prescription Drugs on Oct. 28

TUESDAY, Oct. 24, 2017 (HealthDay News) -- The public is being given its 14th opportunity to safely dispose of pills and patches at collection points operated by the U.S. Drug Enforcement Agency (DEA) and its partners.

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Swedish Massage May Reduce Cancer-Related Fatigue

TUESDAY, Oct. 24, 2017 (HealthDay News) -- Swedish massage therapy (SMT) is associated with clinically significant relief from cancer-related fatigue (CRF) in breast cancer survivors, according to a study published online Oct. 17 in Cancer.

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Ramucirumab Shows Promise in Care of Advanced Gastric Cancer

TUESDAY, Oct. 24, 2017 (HealthDay News) -- Ramucirumab appears to be safe and effective for the treatment of advanced gastric cancer, according to a study published online Sept. 29 in the Journal of Gastroenterology and Hepatology.

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Tofogliflozin Most Effective With High Baseline Insulin

TUESDAY, Oct. 24, 2017 (HealthDay News) -- The sodium glucose co-transporter 2 inhibitor tofogliflozin is effective for reducing fasting plasma glucose and body weight, particularly in patients with a high insulin level at baseline, according to a study published online Oct. 15 in the Journal of Diabetes Investigation.

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Statins May Raise Odds of T2DM in Those at High Risk

TUESDAY, Oct. 24, 2017 (HealthDay News) -- For populations at high-risk for diabetes, statin use is associated with increased risk of developing diabetes, according to a study published online Oct. 23 in BMJ Open Diabetes Research & Care.

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Drinking Water Pre-Vaccination Doesn't Reduce Presyncope

MONDAY, Oct. 23, 2017 (HealthDay News) -- Drinking water before vaccination does not prevent presyncope in adolescents after vaccination, according to a study published online Oct. 23 in Pediatrics.

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Medicaid's Best-Price Rule May Not Be Such a Big Problem

MONDAY, Oct. 23, 2017 (HealthDay News) -- Medicaid's best-price rule is not as serious a problem as drug manufacturers imply, although it may affect novel pricing arrangements, according to an article published online Sept. 28 in the Journal of Health Politics, Policy and Law.

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Caution for PLEX in Progressive Multifocal Leukoencephalopathy

MONDAY, Oct. 23, 2017 (HealthDay News) -- For patients with progressive multifocal leukoencephalopathy (PML), plasma exchange (PLEX) and steroids should be used with caution, according to a study published online Oct. 10 in the Annals of Neurology.

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Limited Evidence of Benefit for Medical Cannabinoids in Children

MONDAY, Oct. 23, 2017 (HealthDay News) -- The strongest evidence for benefit of cannabinoids in children is for chemotherapy-induced nausea and vomiting, with more research needed to assess its role as a medical treatment, according to a review published online Oct. 23 in Pediatrics.

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Herbal and Dietary Supplements Are Commonly Mislabeled

FRIDAY, Oct. 20, 2017 (HealthDay News) -- Mislabeling of herbal and dietary supplements (HDS) is common, occurring in more than half of products tested, according to a study scheduled for presentation at The Liver Meeting, being held by the American Association for the Study of Liver Diseases from Oct. 20 to 24 in Washington, D.C.

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H7N9 Avian Influenza May Be Capable of Pandemic

FRIDAY, Oct. 20, 2017 (HealthDay News) -- A highly pathogenic H7N9 avian influenza variant has evolved and now has the potential to cause a pandemic, according to a study published online Oct. 19 in Cell Host & Microbe.

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Independent Pharmacies Adding Patient Care Services, Products

FRIDAY, Oct. 20, 2017 (HealthDay News) -- Independent pharmacies are expanding the scope of services they offer, partly to absorb lower reimbursements for dispensing prescription medications, according to the 2017 National Community Pharmacists Association (NCPA) Digest.

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For Hepatitis B Patients, Aspirin Tied to Lower Risk of HCC

FRIDAY, Oct. 20, 2017 (HealthDay News) -- Aspirin therapy is associated with a reduced risk of hepatitis B virus-related hepatocellular carcinoma (HCC), according to a study scheduled for presentation at The Liver Meeting, held by the American Association for the Study of Liver Diseases from Oct. 20 to 24 in Washington, D.C.

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High Percentage of HIV-Diagnosed Women Not in Care

FRIDAY, Oct. 20, 2017 (HealthDay News) -- A high percentage of women receiving a new HIV diagnosis have already received this diagnosis in the past but are not undergoing HIV medical care, according to a study published online Oct. 19 in Morbidity and Mortality Weekly Report.

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Gene Tx Approved for Certain Types of B-Cell Lymphoma

THURSDAY, Oct. 19, 2017 (HealthDay News) --Yescarta (axicabtagene ciloleucel) has been approved by the U.S. Food and Drug Administration for individuals with certain types of large B-cell lymphoma who have not responded to or who have relapsed after at least two other kinds of treatment.

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Tofacitinib Superior to Placebo in Active Psoriatic Arthritis

THURSDAY, Oct. 19, 2017 (HealthDay News) -- For patients with active psoriatic arthritis who have an inadequate response to tumor necrosis factor (TNF) inhibitors or to conventional synthetic disease-modifying antirheumatic drugs (DMARDs), tofacitinib is superior to placebo, according to two studies published online Oct. 18 in the New England Journal of Medicine.

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IV Prochlorperazine Beats IV Hydromorphone for Migraine

THURSDAY, Oct. 19, 2017 (HealthDay News) -- Intravenous (IV) hydromorphone is less effective than IV prochlorperazine plus diphenhydramine for acute migraine treatment in the emergency department, according to a study published online Oct. 18 in Neurology.

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Key Stakeholders Discuss How to Make EHRs More Usable

THURSDAY, Oct. 19, 2017 (HealthDay News) -- Key stakeholders and physicians discussed electronic health record (EHR) usability and optimization in the American Medical Association Running Your Practice Community.

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Extended-Release Naltrexone Promising for Opioid Dependence

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Extended-release naltrexone is noninferior to buprenorphine-naloxone for maintaining short-term abstinence from heroin and other illicit substances, according to a study published online Oct. 18 in JAMA Psychiatry.

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Oral Antibiotics Cut Risk of SSI in Colorectal CA Resection

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- For patients undergoing left colon and rectal cancer resections, the addition of oral antibiotics to mechanical bowel preparation (MBP) is associated with a reduced rate of surgical site infections (SSIs), according to a study published online Oct. 18 in JAMA Surgery.

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No Increased Risks for DOAC Use Versus Warfarin in VTE

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- For patients with venous thromboembolism, direct oral anticoagulant (DOAC) use is not associated with increased risk of major bleeding or mortality within the first 90 days compared with warfarin use, according to a study published online Oct. 17 in the BMJ.

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Pre-Exposure Prophylaxis for Homosexual Men Cost-Effective

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Introduction of an HIV pre-exposure prophylaxis (PrEP) program for men who have sex with men (MSM) in the United Kingdom is likely to be cost-effective, according to a study published online Oct. 17 in the The Lancet Infectious Diseases.

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Clinical Evidence Synopsis Published for T2DM

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Adding a sulfonylurea or metformin to insulin is associated with approximately a 1 percent reduction in hemoglobin A1c (HbA1c), and addition of a sulfonylurea (but not metformin) is associated with more hypoglycemic events, according a clinical evidence synopsis published online Oct. 17 in the Journal of the American Medical Association.

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Lifestyle, Metformin Interventions Have Variable Effects

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- For individuals with impaired glucose regulation, the impact of lifestyle and metformin interventions vary for progression to diabetes mellitus (DM) and likelihood of regression to normal glucose regulation (NGR), according to a study published online Oct. 11 in Diabetes Care.

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PPI Use Linked to Increased Risk of Ischemic Stroke, MI

WEDNESDAY, Oct. 18, 2017 (HealthDay News) -- Proton pump inhibitor (PPI) use is associated with increased risk of first-time ischemic stroke and myocardial infarction (MI), according to a study published online Oct. 12 in the Journal of Internal Medicine.

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Glycemic Control Up With Oral Semaglutide in Type 2 Diabetes

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Oral semaglutide is associated with better glycemic control than placebo among type 2 diabetes patients with insufficient glycemic control, according to a study published online Oct. 17 in the Journal of the American Medical Association.

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Potentially Preventable Spending Concentrated in Frail Elderly

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Much of the total potentially preventable spending for Medicare beneficiaries is concentrated among frail elderly individuals, according to a study published online Oct. 16 in the Annals of Internal Medicine.

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Screening Tools Identify Potentially Inappropriate Meds

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Internal medicine patients are frequently prescribed potentially inappropriate medications (PIMs), but screening tools can detect clinically relevant PIMs, according to a study published online Oct. 8 in the Journal of Clinical Pharmacy and Therapeutics.

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Gastric Acid Suppression May Promote Liver Injury

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Based on data from mouse models and humans, a decrease in gastric acid secretion due to use of gastric acid suppressive medications seems to promote overgrowth of intestinal Enterococcus, which promotes liver disease, according to a study published online Oct. 10 in Nature Communications.

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Venovenous Hemodiafiltration Improves Metformin Toxicity

TUESDAY, Oct. 17, 2017 (HealthDay News) -- High-volume continuous venovenous hemodiafiltration (CVVH) and resin-sorbent hemoperfusion is effective for eliminating metformin, according to a case study published online Oct. 5 in the Journal of Diabetes Investigation.

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Ketamine Not Linked to PTSD in Military Trauma Setting

TUESDAY, Oct. 17, 2017 (HealthDay News) -- Ketamine administration is not associated with post-traumatic stress disorder (PTSD) in the military trauma setting, according to a study published online Oct. 3 in Anaesthesia.

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Worse HIV Care Outcomes for Hispanics, Latinos

MONDAY, Oct. 16, 2017 (HealthDay News) -- HIV care outcomes are worse for Hispanics and Latinos, especially for injection drug users, according to a study published online Oct. 12 in Morbidity and Mortality Weekly Report.

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Many College Students Believe Stimulants Can Boost Grades

MONDAY, Oct. 16, 2017 (HealthDay News) -- More than one-quarter of college students report believing that nonmedical use of prescription stimulants (NPS) can improve academic performance, according to a study published in the January 2018 issue of Addictive Behaviors.

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Serious Suffering Affects Almost Half of Those Who Die Yearly

FRIDAY, Oct. 13, 2017 (HealthDay News) -- In 2015, more than 25.5 million people who died worldwide experienced serious health-related suffering (SHS), and the vast majority lacked access to palliative care and pain relief, according to a report published online Oct. 12 in The Lancet.

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Pre-Retirement Morbidity Higher in Later Birth Cohorts

FRIDAY, Oct. 13, 2017 (HealthDay News) -- Americans who must work longer to reach Social Security retirement age have worse measures of health in the years leading up to retirement, according to a study published in the October issue of Health Affairs.

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Liraglutide Not Tied to Higher Risk of Cardiovascular Events

FRIDAY, Oct. 13, 2017 (HealthDay News) -- Liraglutide treatment for weight management is not associated with increased risk of cardiovascular events, according to a study published online Sept. 26 in Diabetes, Obesity and Metabolism.

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New Framework Guides Tx Decisions for Atopic Dermatitis

FRIDAY, Oct. 13, 2017 (HealthDay News) -- A new framework is available to help clinicians determine when systemic therapy is appropriate for treatment of atopic dermatitis (AD), according to a consensus statement published in the October issue of the Journal of the American Academy of Dermatology.

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Court Considering Fate of Noneconomic Damages Cap

THURSDAY, Oct. 12, 2017 (HealthDay News) -- The Wisconsin Supreme Court is considering whether it will hear a case that will determine the fate of the state's $750,000 cap on noneconomic damages, according to an article published by the American Medical Association (AMA).

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Vaccines Elicit Lasting Immune Response Against Ebola

THURSDAY, Oct. 12, 2017 (HealthDay News) -- Two vaccines to prevent Ebola virus disease (EVD) demonstrated immune responses at one month that were largely maintained through 12 months, according to a study published online Oct. 11 in the New England Journal of Medicine.

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High Sustained Response Rate for Glecaprevir, Pibrentasvir in HCV

THURSDAY, Oct. 12, 2017 (HealthDay News) -- For patients with stage 4 or 5 chronic kidney disease and hepatitis C virus (HCV) infection, 12 weeks of treatment with glecaprevir and pibrentasvir results in a high rate of sustained virologic response, according to a study published online Oct. 11 in the New England Journal of Medicine.

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Risk Conferred by T2D Modified by HbA1c in Heart Failure

THURSDAY, Oct. 12, 2017 (HealthDay News) -- For patients with heart failure, the risks conferred by type 2 diabetes (T2D) can be stratified by glycemic control and drug treatments, according to a study published online Oct. 11 in JACC: Heart Failure.

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Neurotoxicity Characterized After Infusion of CD19 CAR-T Cells

THURSDAY, Oct. 12, 2017 (HealthDay News) -- Patients with severe neurotoxicity after infusion of CD19-targeted chimeric antigen receptor-modified T (CAR-T) cells have evidence of endothelial activation, according to a study published online Oct. 12 in Cancer Discovery.

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Eczema Health Care Use Down for Non-Hispanic Black Children

THURSDAY, Oct. 12, 2017 (HealthDay News) -- Non-Hispanic black children have lower health care utilization for eczema, according to a study published online Sept. 27 in the Journal of the American Academy of Dermatology.

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Interventions Have No Long-Term Effect on Inappropriate Rx

WEDNESDAY, Oct. 11, 2017 (HealthDay News) -- Inappropriate antibiotic prescribing for acute respiratory infections (ARIs) increases in the 12 months after removing behavioral interventions compared with control practices, according to a research letter published online Oct. 10 in the Journal of the American Medical Association.

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Crisaborole Safe for Long-Term Treatment of Atopic Dermatitis

WEDNESDAY, Oct. 11, 2017 (HealthDay News) -- Crisaborole ointment appears to be safe for the long-term treatment of atopic dermatitis (AD), according to a study published in the October issue of the Journal of the American Academy of Dermatology.

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HPV Vaccination After Lesion Treatment Is Likely Cost-Effective

WEDNESDAY, Oct. 11, 2017 (HealthDay News) -- For HIV-infected men who have sex with men (MSM), adjuvant quadrivalent human papillomavirus vaccination (qHPV) after treatment of high-grade squamous intraepithelial lesions (HSIL) is likely to be cost-effective, according to a study published online Sept. 12 in Vaccine.

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Statins Tied to Lower Community-Acquired Staph Infection Risk

WEDNESDAY, Oct. 11, 2017 (HealthDay News) -- Statin use is associated with a decreased risk of community-acquired Staphylococcus aureus bacteremia (CA-SAB), particularly in long-term users, according to a study published in the October issue of Mayo Clinic Proceedings.

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Better Glycemic Control With Insulin Pump for Youth With T1D

TUESDAY, Oct. 10, 2017 (HealthDay News) -- For young patients with type 1 diabetes, insulin pump therapy is associated with lower risks of severe hypoglycemia and diabetic ketoacidosis and better glycemic control than insulin injection therapy, according to a study published online Oct. 10 in the Journal of the American Medical Association.

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Medicare Coverage Restrictions for Opioids Rose From '06 to '15

TUESDAY, Oct. 10, 2017 (HealthDay News) -- In an effort to restrict daily allowable prescribed dosing of prescription opioids, Medicare Part D formularies increasingly used quantity limits and prior authorization from 2006 to 2015, according to a research report published online Oct. 9 in the Annals of Internal Medicine.

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Dietary Fat, Relapse Linked in Pediatric Multiple Sclerosis

TUESDAY, Oct. 10, 2017 (HealthDay News) -- For children with multiple sclerosis, increased fat intake is associated with an increased risk of relapse, while vegetable intake may be protective, according to a study published online Oct. 9 in the Journal of Neurology, Neurosurgery & Psychiatry.

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Novel Metrics Suggested for Assessing EHR Use

TUESDAY, Oct. 10, 2017 (HealthDay News) -- Novel metrics have been developed to assess electronic health record (EHR) use and are described in an opinion article published online Oct. 9 in the Annals of Internal Medicine.

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3MR Intervention Effective for Discontinuing Inappropriate Meds

TUESDAY, Oct. 10, 2017 (HealthDay News) -- The Multidisciplinary Multistep Medication Review (3MR) is effective for discontinuation of inappropriate medication among elderly nursing home residents without a decline in their well-being, according to a study published online Oct. 9 in the Annals of Internal Medicine.

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Antibiotic Use Not Linked to Islet, Celiac Disease Autoimmunity

MONDAY, Oct. 9, 2017 (HealthDay News) -- Use of antibiotics in early life is not associated with islet or celiac disease (CD) autoimmunity in children at risk for type 1 diabetes (T1D) or CD, according to a study published online Oct. 9 in JAMA Pediatrics.

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Injured Patients Want More Info on Safety Improvement Efforts

MONDAY, Oct. 9, 2017 (HealthDay News) -- Communication-and-resolution program (CRP) experiences are positive overall for a small majority of patients and families, but they report that hospitals rarely share information about preventing recurrences, according to a study published online Oct. 9 in JAMA Internal Medicine.

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Sizable Number of HIV-Infected Children Not Receiving Care

MONDAY, Oct. 10, 2017 (HealthDay News) -- A substantial proportion of children with diagnosed HIV infection might not be receiving the recommended frequency of medical care, according to a study published online Oct. 5 in Morbidity and Mortality Weekly Report.

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Combo Tx Superior for Polypoidal Choroidal Vasculopathy

MONDAY, Oct. 9, 2017 (HealthDay News) -- Combination therapy consisting of ranibizumab plus verteporfin photodynamic therapy (vPDT) is superior to ranibizumab monotherapy for treatment of eyes with polypoidal choroidal vasculopathy (PCV), according to a study published online Oct. 5 in JAMA Ophthalmology.

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Rate of Adverse Effects for Dapagliflozin Similar to Placebo

MONDAY, Oct. 9, 2017 (HealthDay News) -- The overall incidence of adverse effects (AEs) and serious AEs (SAEs) is similar in patients with type 2 diabetes mellitus taking dapagliflozin or placebo, according to a study published online Sept. 26 in Diabetes, Obesity and Metabolism.

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Michigan Woman Gets Jail Time for Refusing to Vaccinate Son

FRIDAY, Oct. 6, 2017 (HealthDay News) -- A Michigan woman who defied a court order and refused to have her son vaccinated has received a prison sentence.

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Short-Lived Benefits for Abusive Supervisory Behavior

FRIDAY, Oct. 6, 2017 (HealthDay News) -- Engaging in abusive supervisory behavior may be associated with short-term beneficial effects, but over longer periods of time, abusive supervisory behavior is negatively related to supervisors' recovery level and engagement, according to a study published online Sept. 11 in the Academy of Management Journal.

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Pay for Performance Cuts Mortality in Diabetes Patients

FRIDAY, Oct. 6, 2017 (HealthDay News) -- Diabetes disease management through a pay-for-performance (P4P) program cuts diabetes-related, cancer-related, and all-cause mortality, according to a Taiwanese study published online Oct. 5 in the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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No Change in Flu Shot Rates for Children From '15-16 to '16-17

FRIDAY, Oct. 6, 2017 (HealthDay News) -- Children who received an injectable influenza vaccine (IIV) in 2015-2016 were only slightly more likely than those receiving live attenuated influenza vaccine (LAIV) to return the following season for an IIV, according to a study published online Oct. 6 in Pediatrics.

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Stronger Nocebo Effect When Inert Rx Labeled As Expensive

FRIDAY, Oct. 6, 2017 (HealthDay News) -- Nocebo hyperalgesia is stronger when an inert treatment is labeled as being an expensive medication rather than a cheap one, according to a study published online Oct. 5 in Science.

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Most Cancer Drugs Approved in Europe Show No Survival Benefit

FRIDAY, Oct. 6, 2017 (HealthDay News) -- Most cancer drugs that enter the market in Europe have no evidence of benefit for survival or quality of life, according to a study published online Oct. 4 in BMJ.

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Most Ophthalmologists Write Few Opioid Prescriptions

THURSDAY, Oct. 5, 2017 (HealthDay News) -- Most ophthalmologists write no more than 10 opioid prescriptions annually, with a mean supply per prescription of five days, according to a study published online Oct. 5 in JAMA Ophthalmology.

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21 Percent of Americans Report Experiencing a Medical Error

THURSDAY, Oct. 5, 2017 (HealthDay News) -- More than one in five patients report having experienced a medical error, according to a survey released Sept. 28 by the Institute for Healthcare Improvement (IHI)/National Patient Safety Foundation Lucian Leape Institute and NORC at the University of Chicago.

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PFS Up With Obinutuzumab-Based Tx in Follicular Lymphoma

THURSDAY, Oct. 5, 2017 (HealthDay News) -- For patients with follicular lymphoma, obinutuzumab-based immunochemotherapy is associated with longer progression-free survival than rituximab-based therapy, according to a study published online Oct. 4 in the New England Journal of Medicine.

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Maternal Multivitamin Use Tied to Lower Risk of Child ASD

THURSDAY, Oct. 5, 2017 (HealthDay News) -- Multivitamin supplementation during pregnancy is tied to a reduced risk of autism spectrum disorder (ASD) with intellectual disability, according to a study published online Oct. 4 in BMJ.

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Addition of DPP4i to AGI Reduces HbA1c in T2DM

THURSDAY, Oct. 5, 2017 (HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM), inadequately controlled with alpha-glucosidase inhibitors (AGIs), the addition of a dipeptidyl peptidase-4 (DPP4) inhibitor (DPP4i) is associated with a greater reduction in hemoglobin A1c (HbA1c), according to a review published online Sept. 26 in the Journal of Diabetes Investigation.

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Provider Advice Impacts Breast Cancer Prevention Decisions

WEDNESDAY, Oct. 4, 2017 (HealthDay News) -- For patients at high risk for breast cancer, health care provider (HCP) recommendation is the most important factor for deciding whether to use selective estrogen receptor modulators (SERMs), according to a study published online Oct. 4 in Cancer Prevention Research.

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Anticoagulants With Other Drugs Raise Bleeding Risk in AF

WEDNESDAY, Oct. 4, 2017 (HealthDay News) -- Nonvalvular atrial fibrillation (AF) patients who take non-vitamin K oral anticoagulants (NOACs) along with certain other medications are at increased risk for major bleeding, and antithrombotic medications are significantly associated with increased rates of hematuria-related complications in older adults, according to two studies published online Oct. 3 in the Journal of the American Medical Association.

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LAMA Plus LABA Tied to Fewer Exacerbations in Stable COPD

WEDNESDAY, Oct. 4, 2017 (HealthDay News) -- Treatment with long-acting muscarinic antagonists (LAMA) plus long-acting β-agonists (LABA) is associated with fewer exacerbation events in patients with chronic obstructive pulmonary disease (COPD), according to a clinical evidence synopsis published online Oct. 3 in the Journal of the American Medical Association.

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Commercialization of Generics Impacts Adverse Event Rates

WEDNESDAY, Oct. 4, 2017 (HealthDay News) -- Immediate or delayed differences in adverse event rates were seen after generic commercialization of three antihypertensive drugs, according to a study published online Oct. 3 in Circulation: Cardiovascular Quality and Outcomes.

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Process Promising for On-Site Printing of Custom-Dosed Meds

WEDNESDAY, Oct. 4, 2017 (HealthDay News) -- Small molecular medicines can be printed precisely using organic vapor jets, according to a study published online Sept. 27 in Nature Communications.

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Insulinomas May Hold Key to Diabetes Drug Development

WEDNESDAY, Oct. 4, 2017 (HealthDay News) -- An analysis of whole-exome and RNA sequencing data reveals mutations, copy number variants, and/or dysregulation of epigenetic modifying genes in insulinomas, which may be candidates for inducing beta cell regeneration, according to a study published online Oct. 3 in Nature Communications.

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Smoking Cessation Support Less Likely for Cancer Patients

WEDNESDAY, Oct. 4, 2017 (HealthDay News) -- General practitioners are less likely to support cessation of smoking in patients with cancer than in those with coronary heart disease (CHD), according to a study published online Sept. 11 in the Annals of Family Medicine.

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Communication Program Doesn't Raise Hospital Liability Costs

TUESDAY, Oct. 3, 2017 (HealthDay News) -- A communication-and-resolution program, in which hospitals and liability insurers communicate with patients when adverse events occur, does not lead to higher liability costs, according to a study published online Oct. 2 in Health Affairs.

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Fewer Deaths Projected With Switch to Electronic Cigarettes

TUESDAY, Oct. 3, 2017 (HealthDay News) -- Replacement of cigarettes with electronic cigarettes (e-cigarettes) is projected to result in fewer premature deaths, even under a pessimistic scenario, according to a study published online Oct. 2 in Tobacco Control.

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Sodium-Glucose Cotransporter 2 Inhibitors Not Cancer Risk Factor

TUESDAY, Oct. 3, 2017 (HealthDay News) -- Over the short term there is not a significantly increased overall cancer risk among individuals with type 2 diabetes using sodium-glucose cotransporter 2 (SGLT2) inhibitors, according to a study published in the October issue of Diabetologia.

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Hospital Discharges for Prescription Opioids Have Fallen

TUESDAY, Oct. 3, 2017 (HealthDay News) -- Prescription opioid-related inpatient and emergency department (ED) discharges have decreased since 2010, while heroin-related discharges have increased sharply since 2008, according to a study published online Oct. 2 in Health Affairs.

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High Epsom Salt Intake Can Lead to Severe Liver Injury

TUESDAY, Oct. 3, 2017 (HealthDay News) -- Epsom salt intake can lead to severe liver injury in predisposed patients, according to a case study published online Oct. 2 in BMJ Case Reports.

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Opioid Manufacturers to Provide Doctor Training

MONDAY, Oct. 2, 2017 (HealthDay News) -- In an effort to halt the ongoing opioid addiction crisis, U.S. regulators are requiring manufacturers to provide extensive training to doctors, according to a report published by the Associated Press.

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Vancomycin + Piperacillin/ Tazobactam Ups Kidney Risk

MONDAY, Oct. 2, 2017 (HealthDay News) -- For hospitalized children, coadministration of intravenous (IV) vancomycin and piperacillin/tazobactam is associated with increased risk of acute kidney injury (AKI), according to a study published online Oct. 2 in JAMA Pediatrics.

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Low-Dose Alteplase No Better for Acute Ischemic Stroke

MONDAY, Oct. 2, 2017 (HealthDay News) -- For key demographic subgroups of patients with acute ischemic stroke (AIS), low-dose alteplase does not differ from standard-dose alteplase in terms of treatment effects on death or disability, according to a study published online Oct. 2 in JAMA Neurology.

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Legal Cannabis Use Common Among Cancer Patients

MONDAY, Oct. 2, 2017 (HealthDay News) -- In Washington state, where cannabis is legal, cancer patients have high rates of active use, and they report that legalization was an important factor in their decision to use, according to a study published online Sept. 25 in Cancer.

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Tdap Given in Pregnancy Protects Infants From Pertussis

MONDAY, Oct. 2, 2017 (HealthDay News) -- Tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination during the third trimester of pregnancy is effective for preventing pertussis in infants in the first months of life, according to a study published online Sept. 28 in Clinical Infectious Diseases.

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Azathioprine Appears to Improve Disease Course in Early Crohn's

MONDAY, Oct. 2, 2017 (HealthDay News) -- Long-term use of azathioprine (AZA) is associated with a better disease course in patients with early Crohn's disease (CD), according to a study published online Sept. 22 in the Journal of Gastroenterology and Hepatology.

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Liraglutide Tied to Significant Weight Loss in Obese

MONDAY, Oct. 2, 2017 (HealthDay News) -- Liraglutide significantly increases weight loss in obese patients, likely by slowing gastric emptying of solids, according to a pilot study published online Sept. 25 in The Lancet Gastroenterology & Hepatology.

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Hypermutated ctDNA Linked to Checkpoint Inhibitor Response

MONDAY, Oct. 2, 2017 (HealthDay News) -- For patients with diverse malignancies, hypermutated blood-derived circulating tumor DNA (ctDNA) is associated with checkpoint inhibitor response, according to a study published online Oct. 2 in Clinical Cancer Research.

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