October 2016 Briefing - Hematology & Oncology

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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for October 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Initiation, Adherence to AIs Low for Older Women With DCIS

MONDAY, Oct. 31, 2016 (HealthDay News) -- For older women with estrogen receptor (ER)-positive ductal carcinoma in situ (DCIS), initiation of aromatase inhibitors (AIs) and adherence to treatment are low, according to a study published online Oct. 25 in Cancer.

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Older, Younger Women Equally Benefit From Breast Recon

MONDAY, Oct. 31, 2016 (HealthDay News) -- Older breast cancer patients who have undergone mastectomy benefit as much as younger women from breast reconstruction, according to a study published online Oct. 26 in the Journal of the American College of Surgeons.

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Few Changes in Employer-Sponsored Insurance 2013-2014

MONDAY, Oct. 31, 2016 (HealthDay News) -- Private sector employer-sponsored health insurance offerings were similar in 2013 and 2014, with <3.5 percent of employers dropping coverage and 1.1 percent adding coverage, according to a report published online Oct. 26 in Health Affairs.

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Whites Have Longest Survival in Cutaneous Melanoma

FRIDAY, Oct. 28, 2016 (HealthDay News) -- For patients with cutaneous melanoma, whites have the longest survival time, according to a study published in the November issue of the Journal of the American Academy of Dermatology.

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Useful Tips Offered for Addressing Negative Patient Reviews

FRIDAY, Oct. 28, 2016 (HealthDay News) -- In an article published in Medical Economics, five tips are presented to address negative patient reviews.

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Review: Reduced Risk of Death for Left-Sided Colon Cancer

THURSDAY, Oct. 27, 2016 (HealthDay News) -- The side of origin of colon cancer (CC) impacts prognosis, with reduced risk of death for left-sided CC (LCC), according to a review published online Oct. 27 in JAMA Oncology.

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Cancer Survivors Have Higher Rate of Antidepressant Use

THURSDAY, Oct. 27, 2016 (HealthDay News) -- Treatment for depression and anxiety is nearly twice as common among U.S. cancer survivors as it is for those with no history of cancer, according to a study published online Oct. 26 in the Journal of Clinical Oncology.

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Mohs Effective for Melanoma in Situ of Trunk, Extremities

THURSDAY, Oct. 27, 2016 (HealthDay News) -- Mohs micrographic surgery is efficacious for melanoma in situ (MIS) on the trunk and proximal extremities, with a margin of 9 mm needed to excise 97 percent of MIS, according to a study published in the November issue of the Journal of the American Academy of Dermatology.

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Statins Offset Insulin-Related Cancer Risk in T2DM

WEDNESDAY, Oct. 26, 2016 (HealthDay News) -- For patients with type 2 diabetes mellitus (T2DM), use of statins offsets insulin-related cancer risks, according to research published online Oct. 21 in the Journal of Internal Medicine.

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Low CA Risk for Premenopausal Abnormal Uterine Bleeding

WEDNESDAY, Oct. 26, 2016 (HealthDay News) -- Premenopausal women with abnormal uterine bleeding have low risk of endometrial cancer and atypical hyperplasia, according to a review published online Oct. 20 in BJOG: An International Journal of Obstetrics and Gynaecology.

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Survival Outcomes Similar for Short-, Long-Term Blood Storage

TUESDAY, Oct. 25, 2016 (HealthDay News) -- Using the freshest blood for transfusions does not appear to significantly improve patient survival, according to a study published online Oct. 24 in the New England Journal of Medicine.

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Recommendations for Secondary Prevention of Cervical Cancer

TUESDAY, Oct. 25, 2016 (HealthDay News) -- In a Clinical Practice Guideline published online Oct. 12 in the Journal of Global Oncology, recommendations are presented for the secondary prevention of cervical cancer.

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Rx Subsidy Ups Persistence to Breast Cancer Hormone Therapy

TUESDAY, Oct. 25, 2016 (HealthDay News) -- For white, black, and Hispanic women, receipt of a prescription subsidy is associated with improved persistence to breast cancer hormone therapy, according to a study published online Oct. 17 in the Journal of Clinical Oncology.

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Factors ID'd for Recurrence After Radical Cystectomy

TUESDAY, Oct. 25, 2016 (HealthDay News) -- For patients undergoing robot-assisted radical cystectomy, predictors of recurrence include mainly tumor characteristics, according to a study published in the October issue of The Journal of Urology.

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Advantages of FIT As CRC Screening Method Discussed

TUESDAY, Oct. 25, 2016 (HealthDay News) -- Fecal immunochemical testing (FIT) has advantages as a colorectal cancer (CRC) screening method, and should be a component of a screening program, according to an Ideas and Opinions piece published online Oct. 25 in the Annals of Internal Medicine.

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More Than Half of Melanomas Are Self-Detected

TUESDAY, Oct. 25, 2016 (HealthDay News) -- More than half of melanomas are self-detected, and more melanomas are self-detected by women than men, according to a study published in the November issue of the Journal of the American Academy of Dermatology.

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Smoking Still Responsible for Many U.S. Cancer Deaths

MONDAY, Oct. 24, 2016 (HealthDay News) -- Nearly one-third of cancer deaths among Americans aged 35 or older are caused by smoking, and the rate is much higher in the South, according to research published online Oct. 24 in JAMA Internal Medicine.

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Fewer Uncertain Thyroid Results With Core Needle vs Repeat FNA

MONDAY, Oct. 24, 2016 (HealthDay News) -- To reduce inconclusive results for thyroid nodules, core-needle biopsy (CNB) is more effective than repeat fine-needle aspiration (FNA), according to a study published online Oct. 5 in Head & Neck.

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Higher Grade Disease at Prostatectomy With Surveillance

FRIDAY, Oct. 21, 2016 (HealthDay News) -- For men with low-risk prostate cancer, those who enter active surveillance have higher grade of disease at prostatectomy, but no difference in other adverse pathological outcomes, compared to those undergoing immediate surgery, according to a study published in the November issue of The Journal of Urology.

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Bundled-Payment Program Deemed Better for Breast CA Care

FRIDAY, Oct. 21, 2016 (HealthDay News) -- For breast cancer care, a bundled-payment program is associated with better adherence to quality indicators and better outcomes over time compared with a fee-for-service (FFS) program, according to a study published online Oct. 19 in JAMA Oncology.

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Men With Genetic Risk of CRC May Lower Risk Via Healthy Lifestyle

THURSDAY, Oct. 20, 2016 (HealthDay News) -- Healthy living can lower the odds for colorectal cancer (CRC) for men who are at high genetic risk for the disease, according to research published online recently in Genetics in Medicine.

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Surveillance Rates on Rise in Low-Risk Prostate Cancer

THURSDAY, Oct. 20, 2016 (HealthDay News) -- More than 90 percent of men in Sweden who have very low-risk prostate cancer choose close monitoring rather than immediate treatment -- and more American men should use that option, according to a study published online Oct. 20 in JAMA Oncology.

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Superior Morbidity Profile for Robotic Partial Nephrectomy

THURSDAY, Oct. 20, 2016 (HealthDay News) -- Compared with laparoscopic partial nephrectomy, robotic partial nephrectomy is associated with a superior morbidity profile, according to a meta-analysis published in the November issue of The Journal of Urology.

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FDA Approves New Treatment for Advanced Soft Tissue Sarcoma

WEDNESDAY, Oct. 19, 2016 (HealthDay News) -- Lartruvo (olaratumab) has been approved by the U.S. Food and Drug Administration to treat adults with certain soft tissue sarcomas.

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Financial Toxicity Is a Relevant Cancer Outcome Measure

WEDNESDAY, Oct. 19, 2016 (HealthDay News) -- Financial toxicity is a clinically relevant outcome for patients receiving treatment for advanced cancer, according to a study published online Oct. 7 in Cancer.

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Less Frequent Cervical CA Screens May Be OK After HPV Vaccine

TUESDAY, Oct. 18, 2016 (HealthDay News) -- Women vaccinated with earlier versions of the human papillomavirus (HPV) vaccine may only need cervical cancer screening every five years starting at age 25 or 30, and women who've received the updated vaccine need screening even less often, according to a study published online Oct. 17 in the Journal of the National Cancer Institute.

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HBV, HCV Coinfection Ups Non-Hodgkin Risk in ART-Treated HIV

TUESDAY, Oct. 18, 2016 (HealthDay News) -- Chronic coinfection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is associated with non-Hodgkin's lymphoma (NHL) among patients with HIV receiving antiretroviral treatment (ART), according to a study published online Oct. 18 in the Annals of Internal Medicine.

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Topotecan-Based Therapy Beneficial for Retinoblastoma

TUESDAY, Oct. 18, 2016 (HealthDay News) -- For patients with advanced retinoblastoma, topotecan combined with vincristine, carboplatin, and aggressive focal therapies is effective, according to a study published online Oct. 10 in the Journal of Clinical Oncology.

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New Recs for RBC Transfusion, Optimal RBC Storage Length

MONDAY, Oct. 17, 2016 (HealthDay News) -- In a clinical practice guideline published online Oct. 12 in the Journal of the American Medical Association, recommendations are presented for the target hemoglobin level for red blood cell (RBC) transfusion and optimal duration of RBC storage.

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Mutations Identified in Uterine, Ovarian Carcinosarcomas

MONDAY, Oct. 17, 2016 (HealthDay News) -- Carcinosarcomas (CSs) of the uterus and ovary have mutations in cancer genes previously identified in uterine and ovarian carcinomas and in genes encoding histones H2A and H2B, according to a study published online Oct. 10 in the Proceedings of the National Academy of Sciences.

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Psychoeducational Intervention Reduces Fear of CA Recurrence

MONDAY, Oct. 17, 2016 (HealthDay News) -- A psychoeducational intervention is effective for reducing fear of cancer recurrence (FCR) among patients with ongoing melanoma care, according to a study published online Oct. 10 in the Journal of Clinical Oncology.

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Lower Monthly Premiums for Narrow-Network Plans

MONDAY, Oct. 17, 2016 (HealthDay News) -- Narrow-network health insurance plans have lower monthly premiums than larger-network plans, according to a study published in the October issue of Health Affairs.

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High BMI, Large Waist, T2DM Tied to Increased Odds of Liver Cancer

FRIDAY, Oct. 14, 2016 (HealthDay News) -- Having a large waistline, a high body mass index (BMI), and type 2 diabetes may raise risk for liver cancer, according to research published online Oct. 14 in Cancer Research.

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Snus Use Tied to Higher Risk of Prostate Cancer Mortality

FRIDAY, Oct. 14, 2016 (HealthDay News) -- A type of smokeless tobacco called snus may increase a prostate cancer patient's mortality risk, according to a study published online Oct. 12 in the International Journal of Cancer.

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Androgen Deprivation Therapy May Raise Dementia Risk

FRIDAY, Oct. 14, 2016 (HealthDay News) -- The risk of dementia might be doubled for prostate cancer patients who are treated with androgen-deprivation therapy (ADT), according to a study published online Oct. 13 in JAMA Oncology.

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Downward Trend in U.S. Breast Cancer Mortality Continues

FRIDAY, Oct. 14, 2016 (HealthDay News) -- The racial gap for breast cancer mortality is closing, particularly among younger women, according to research published in the Oct. 14 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Obesity Ups Risk for Secondary Primary Cancers in Men

FRIDAY, Oct. 14, 2016 (HealthDay News) -- Obesity before a cancer diagnosis is associated with an increased risk for overall and individual secondary primary cancers (SPCs) in males, according to a study published online Oct. 10 in the Journal of Clinical Oncology.

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Ovarian Preservation Doesn't Impact Prognosis in Cervical CA

THURSDAY, Oct. 13, 2016 (HealthDay News) -- For women with early-stage cervical adenocarcinoma, ovarian preservation does not impact survival, according to a study published in the October issue of the American Journal of Obstetrics & Gynecology.

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Study Finds Mammograms Lead to High Rate of Overdiagnosis

THURSDAY, Oct. 13, 2016 (HealthDay News) -- Mammography screening is much more likely to find insignificant breast tumors than it is to catch potentially life-threatening cancer in its early stages, according to a study published in the Oct. 13 issue of the New England Journal of Medicine.

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Cryoablation May Be Alternative to Breast Cancer Surgery

WEDNESDAY, Oct. 12, 2016 (HealthDay News) -- Cryoablation can successfully treat the majority of small breast cancers with few side effects or complications, according to a small study published recently in the Annals of Surgical Oncology.

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Social Reintegration of Hodgkin's Survivors Impeded by Fatigue

WEDNESDAY, Oct. 12, 2016 (HealthDay News) -- Severe fatigue (sFA) can impede social reintegration in Hodgkin's lymphoma (HL) survivors, according to a study published online Oct. 3 in the Journal of Clinical Oncology.

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Costs of Chemo for Breast Cancer Vary Widely in the United States

TUESDAY, Oct. 11, 2016 (HealthDay News) -- Breast cancer chemotherapy costs can vary by tens of thousands of dollars in the United States, depending on the course of treatment doctors select, according to a study published online Oct. 10 in Cancer.

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Copay Assist Programs Creating Problems in Health Care Markets

TUESDAY, Oct. 11, 2016 (HealthDay News) -- Despite offering assistance to individuals who cannot afford expensive medications, copay assistance programs create broader problems in health care markets, according to an Ideas and Opinions piece published online Oct. 11 in the Annals of Internal Medicine.

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Radiomic-Based Method Predicts Recurrent Glioblastoma Outcome

TUESDAY, Oct. 11, 2016 (HealthDay News) -- A radiomic-based approach can be used to generate a prediction model for stratifying treatment outcome among patients with recurrent glioblastoma prior to bevacizumab treatment, according to a study published online Oct. 10 in Clinical Cancer Research.

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U.S. Health Care System Is One of the Least Efficient Worldwide

MONDAY, Oct. 10, 2016 (HealthDay News) -- The U.S. health care system is one of the least efficient worldwide based on a Bloomberg index that assesses life expectancy, health care spending per capita, and relative spending as a share of gross domestic product, according to a report published by Bloomberg.

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Most Women Feel PCPs Are Involved in Breast Cancer Care

MONDAY, Oct. 10, 2016 (HealthDay News) -- Most women newly diagnosed with breast cancer perceive high primary care provider (PCP) quality, and report that their PCPs have high engagement and communication, according to research published online Oct. 3 in the Journal of Clinical Oncology.

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Global Burden of Disease Report Evaluates the World's Health

FRIDAY, Oct. 7, 2016 (HealthDay News) -- The United States lags behind other advanced nations when it comes to infant mortality and the life expectancy of its citizens, according to a comprehensive review of global health statistics published in the Oct. 8 issue of The Lancet.

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Strategies Presented for Managing Physician Burnout

FRIDAY, Oct. 7, 2016 (HealthDay News) -- Effective strategies for managing physician burnout include mindfulness and stress-management training, according to a review published online Sept. 28 in The Lancet.

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Adding Daratumumab to Standard Tx Effective in Multiple Myeloma

FRIDAY, Oct. 7, 2016 (HealthDay News) -- Adding daratumumab to standard treatment for advanced cases of multiple myeloma may significantly improve patients' chances of a response and even recovery, according to a study published in the Oct. 6 issue of the New England Journal of Medicine.

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Price Increases Larger for Older Cancer Drugs Than Newer Ones

FRIDAY, Oct. 7, 2016 (HealthDay News) -- After adjusting for inflation, nearly two-thirds of 86 cancer medications had price increases between 2010 and 2015, according to a research letter published online Oct. 6 in JAMA Oncology.

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Long-Term Tamoxifen Does Lower Contralateral Breast Cancer Risk

FRIDAY, Oct. 7, 2016 (HealthDay News) -- Treatment with tamoxifen or aromatase inhibitors does cut breast cancer patients' risk of developing cancer in their other breast, according to findings published online Oct. 6 in JAMA Oncology.

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Variation in Medicare Payments for Peri-Op Complications

FRIDAY, Oct. 7, 2016 (HealthDay News) -- For patients undergoing four selected inpatient operations, there is considerable variation across hospitals in Medicare payments for those rescued from perioperative complications, according to a study published online Oct. 5 in JAMA Surgery.

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Low Incidence of Cervical Cancer, CIN3+ for HPV-Negative Women

THURSDAY, Oct. 6, 2016 (HealthDay News) -- Human papillomavirus (HPV)-negative women have low long-term incidence of cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 or worse (CIN3+), which supports an extension of the cervical screening interval beyond five years for certain women, according to a study published online Oct. 4 in The BMJ.

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Changes in Depression Symptoms Tied to Mortality in Lung Cancer

THURSDAY, Oct. 6, 2016 (HealthDay News) -- Longitudinal changes in depression are associated with differences in mortality among patients with lung cancer, according to a study published online Oct. 3 in the Journal of Clinical Oncology.

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U.S. Smoking Rates Vary Across Counties Within States

WEDNESDAY, Oct. 5, 2016 (HealthDay News) -- Parts of the Midwest and South have the highest smoking rates in the United States, according to a study published online Oct. 1 in Cancer Epidemiology, Biomarkers & Prevention.

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Delay in Post-Mastectomy Reconstruction May Fuel Anxiety

TUESDAY, Oct. 4, 2016 (HealthDay News) -- Breast reconstruction immediately after breast removal surgery due to cancer may help reduce a patient's mental distress, according to a study published in the October issue of Plastic and Reconstructive Surgery.

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Biologics Tied to Opportunistic Infection Risk in IBD

TUESDAY, Oct. 4, 2016 (HealthDay News) -- For adults with inflammatory bowel disease (IBD), biologic agents increase the risk of infection, especially opportunistic infection, but do not increase the risk of serious infection or malignancy, according to a review published in the October issue of Clinical Gastroenterology and Hepatology.

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Patient Satisfaction Up With Pharmacist-Managed Warfarin Tx

TUESDAY, Oct. 4, 2016 (HealthDay News) -- Pharmacist-managed warfarin anticoagulation therapy is associated with improved patient satisfaction, although the benefits in terms of control, safety, and mortality are unclear, according to a review published online Sept. 28 in the Journal of Clinical Pharmacy and Therapeutics.

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Doctors Spending in Excess of $32,000 on Health IT

TUESDAY, Oct. 4, 2016 (HealthDay News) -- Doctors are spending more than $32,000 per year on health information technology (IT), according to an article published in Medical Economics.

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Radiotherapy Aids Regional Control of Node+ Melanoma

TUESDAY, Oct. 4, 2016 (HealthDay News) -- Radiotherapy is effective in regional control of node-positive malignant melanoma, but patients are at risk of early distant relapse, according to a study published Sept. 25 in the Journal of Medical Imaging and Radiation Oncology.

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New AMA Module Helps Identify Physician Distress

MONDAY, Oct. 3, 2016 (HealthDay News) -- A new resource has been developed to help physicians identify distressed colleagues and help them to access care, according to a report published by the American Medical Association (AMA).

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CT Colonography May Be Useful for Aneurysm Detection

MONDAY, Oct. 3, 2016 (HealthDay News) -- Routine assessment of the aorta during a computed tomography colonography (CTC) may aid in aneurysm detection, according to a study published online Sept. 21 in the Journal of Medical Imaging and Radiation Oncology.

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Statins Reduce Risk of Mortality in Multiple Myeloma

MONDAY, Oct. 3, 2016 (HealthDay News) -- Statin therapy is associated with reduced risk of all-cause and multiple myeloma (MM)-specific mortality, according to a study published online Sept. 19 in the Journal of Clinical Oncology.

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