November 2017 Briefing - Internal Medicine

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Here are what the editors at HealthDay consider to be the most important developments in Internal Medicine for November 2017. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Severe Hypoglycemia a Potent Marker of Cardiovascular Risk

THURSDAY, Nov. 30, 2017 (HealthDay News) -- Among patients with diabetes, severe hypoglycemia is associated with high absolute risk of cardiovascular events and mortality, according to a study published online Nov. 10 in Diabetes Care.

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Physicians Report High Rate of Uncontrolled Atopic Dermatitis

THURSDAY, Nov. 30, 2017 (HealthDay News) -- Physicians rate a high proportion of patients with atopic dermatitis (AD) as having inadequate disease control, according to a study published online Nov. 13 in the Journal of Dermatology.

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Incidence of HIV Dropped From 1999 to 2016 in Uganda

THURSDAY, Nov. 30, 2017 (HealthDay News) -- The incidence of HIV infection declined significantly in Uganda between 1999 and 2016, according to a study published in the Nov. 30 issue of the New England Journal of Medicine.

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Fremanezumab, Erenumab Effective in Treatment of Migraine

THURSDAY, Nov. 30, 2017 (HealthDay News) -- Fremanezumab is effective for the prevention of chronic migraine, and erenumab is beneficial for treatment of episodic migraine, according to two studies published in the Nov. 30 issue of the New England Journal of Medicine.

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More Than Half Today's Children Expected to Be Obese at 35

THURSDAY, Nov. 30, 2017 (HealthDay News) -- More than half of today's children are expected to be obese at the age of 35 years, with about half of the prevalence occurring during childhood, according to a study published in the Nov. 30 issue of the New England Journal of Medicine.

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FODMAP Diet Beats General Dietary Advice for IBS

THURSDAY, Nov. 30, 2017 (HealthDay News) -- While both improve gastrointestinal symptoms, the low Fermentable Oligo-Di-Mono-saccharides and polyols (FODMAP) diet shows greater benefit for patients with irritable bowel syndrome (IBS) than general dietary advice (GDA), according to a study published online Nov. 20 in the Journal of Gastroenterology and Hepatology.

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Leaving the House Tied to Lower Mortality Risk in Seniors

THURSDAY, Nov. 30, 2017 (HealthDay News) -- Elderly individuals who frequently leave the house have a lower risk of mortality, according to a study published online Nov. 22 in the Journal of the American Geriatrics Society.

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Mortality Up for Some Cancers in Urban-Dwelling Native Americans

THURSDAY, Nov. 30, 2017 (HealthDay News) -- Urban American Indians and Alaskan Natives (AIAN) with cancer have a significantly higher comorbidity burden, and have higher mortality for some cancers, according to a study published online Nov. 29 in Cancer Research.

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Magnesium Boosts Environmental Enrichment in Alzheimer's

THURSDAY, Nov. 30, 2017 (HealthDay News) -- The combination of environmental enrichment (EE) and magnesium-L-threonate (MgT) is more effective than either treatment alone for improving cognition and spatial memory in a mouse model of Alzheimer's disease (AD), according to a study published online Nov. 10 in CNS Neuroscience & Therapeutics.

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Unapproved Drugs Identified in Androgen Receptor Modulators

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- Products marketed as selective androgen receptor modulators and sold via the internet frequently contain unapproved drugs and substances, and the amount of active compound often does not match that listed on the label, according to a study published in the Nov. 28 issue of the Journal of the American Medical Association.

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Many Seniors Have Not Discussed Avoiding Drug Interactions

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- Older adults report feeling confident that they know how to avoid drug interactions despite only 35 percent having spoken to someone about it in the past year, according to findings from the National Poll on Healthy Aging, published online Nov. 29.

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Doctors Increasingly Becoming 'Nursing Home Specialists'

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- From 2012 to 2015 there was a relative increase in the number of nursing home specialists, including an increasing number of generalist physicians billing for nursing home care, according to a research letter published in the Nov. 28 issue of the Journal of the American Medical Association.

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Wait Time Linked to Worse Outcomes in Hip Fracture Surgery

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- Increased wait time is associated with an increased risk of complications and 30-day mortality among adults undergoing hip fracture surgery, according to a study published in the Nov. 28 issue of the Journal of the American Medical Association.

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Fecal Microbial Transplant by Oral Capsule Noninferior for CDI

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- For patients with recurrent Clostridium difficile infection (RCDI), fecal microbial transplantation (FMT) with oral capsules is noninferior to FMT by colonoscopy, according to a study published in the Nov. 28 issue of the Journal of the American Medical Association.

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AAFP Issues Summary of 2018 Final Medicare Fee Schedule

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- A four-page executive summary of the 2018 final Medicare physician fee schedule that was released by the Centers for Medicare & Medicaid Services (CMS) has been published by the American Academy of Family Physicians.

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Over 5 Percent of Incident Cancer Due to Diabetes, High BMI

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- More than 5 percent of all incident cancers in 2012 were attributable to diabetes and high body mass index (BMI), according to a study published online Nov. 28 in The Lancet Diabetes & Endocrinology.

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Recommendations Developed for Lymphangioleiomyomatosis

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- Evidence-based recommendations have been developed for the diagnosis and treatment of patients with lymphangioleiomyomatosis (LAM), and published in the Nov. 15 issue of the American Journal of Respiratory and Critical Care Medicine.

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Patients Often Uncomfortable With Overlapping Surgeries

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- On average, patients are neutral toward or uncomfortable with concurrent or overlapping surgical procedures, according to a study published in the Nov. 15 issue of The Journal of Bone & Joint Surgery.

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Endocrine-Disrupting Chemicals Linked to Diabetes Disparities

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- Disparities in exposure to diabetes-associated environmental endocrine-disrupting chemicals (EDCs) may contribute to disparities in diabetes, according to a review published online Nov. 15 in Diabetes Care.

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Education Program Builds GP's Knowledge of Radiation Therapy

WEDNESDAY, Nov. 29, 2017 (HealthDay News) -- Australia's national education program improves general practitioner (GP) knowledge about radiation therapy (RT) and may influence patient referrals for RT, according to a study published online Oct. 28 in the Journal of Medical Imaging and Radiation Oncology.

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CDC: HIV Being Diagnosed Sooner After Infection

TUESDAY, Nov. 28, 2017 (HealthDay News) -- HIV is being diagnosed sooner after infection than previously reported, according to a Nov. 28 press release issued by the U.S. Centers for Disease Control and Prevention.

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Measuring Plasma PCSK9 May ID Resistance to PCSK9 Inhibitors

TUESDAY, Nov. 28, 2017 (HealthDay News) -- Plasma levels of proprotein convertase subtilisin/kexin type 9 (PCSK9) may help assess apparent resistance to PCSK9 inhibitors, according to a research letter published online Nov. 28 in the Annals of Internal Medicine.

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Prevalence of Arthritis Underestimated in United States

TUESDAY, Nov. 28, 2017 (HealthDay News) -- The prevalence of arthritis in the United States seems to have been underestimated, with 91.2 million adults affected in 2015, according to a study published online Nov. 27 in Arthritis & Rheumatology.

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Value-Based Payment Modifier Not Tied to Practice Performance

TUESDAY, Nov. 28, 2017 (HealthDay News) -- The Value-Based Payment Modifier (VM) is not associated with performance differences between practices serving higher-risk and lower-risk patients, according to a study published online Nov. 28 in the Annals of Internal Medicine.

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Clinician Denial of Patient Requests Impacts Satisfaction

TUESDAY, Nov. 28, 2017 (HealthDay News) -- Clinician denial of some types of tests requested by patients is associated with worse patient satisfaction with the clinician, according to a study published online Nov. 27 in JAMA Internal Medicine.

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Guidance Issued for Seasonal Allergic Rhinitis Pharmacologic Tx

TUESDAY, Nov. 28, 2017 (HealthDay News) -- A workgroup from the Joint Task Force on Practice Parameters has reviewed evidence and provided guidance for health care providers regarding treatment of seasonal allergic rhinitis in patients aged 12 years or older. The clinical guideline was published online Nov. 28 in the Annals of Internal Medicine.

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Less Frequent Biopsy May Be Option in Prostate Cancer Care

TUESDAY, Nov. 28, 2017 (HealthDay News) -- Biennial biopsies are an acceptable alternative to annual biopsies for men managing low-risk prostate cancer through active surveillance (AS), according to a research published online Nov. 27 in the Annals of Internal Medicine.

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1998 to 2014 Saw Drop in CVD Hospitalization Rates in Diabetes

TUESDAY, Nov. 28, 2017 (HealthDay News) -- Cardiovascular disease (CVD) hospitalization rates have declined in recent years among individuals with and those without diabetes, according to a study published online Nov. 17 in Diabetes Care.

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Simple ECG May Help Distinguish MDD From Bipolar Depression

TUESDAY, Nov. 28, 2017 (HealthDay News) -- Heart rate variability (HRV) and specific inflammatory biomarkers can differentiate major depressive disorder (MDD) from depression in bipolar disorder (BD), according to a study published online Oct. 5 in The World Journal of Biological Psychiatry.

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Risk of ≥CIN3 Drops With Negative HPV, Cytology Co-Tests

TUESDAY, Nov. 28, 2017 (HealthDay News) -- The five-year risks of cervical intraepithelial neoplasia grade 3 (CIN3), adenocarcinoma in situ, and cervical cancer (≥CIN3) decrease after each successive negative human papillomavirus (HPV) and cytology co-testing, according to a study published online Nov. 27 in the Annals of Internal Medicine.

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Similar Efficacy for Intranasal, Intramuscular Naloxone

TUESDAY, Nov. 28, 2017 (HealthDay News) -- For reversal of opioid overdose, higher-concentration intranasal naloxone has similar efficacy to that of intramuscular naloxone administered at the same dose, according to a review published online Nov. 27 in the Annals of Internal Medicine.

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Sex, Race, Age Disparities in Survival for HPV-Linked Cancer

TUESDAY, Nov. 28, 2017 (HealthDay News) -- For patients with human papillomavirus (HPV)-associated cancers, there are large disparities in survival based on sex, race, and age, according to a study published online Nov. 6 in Cancer.

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Abdominal Obesity Linked to All-Cause Mortality in HFpEF

MONDAY, Nov. 27, 2017 (HealthDay News) -- For patients with heart failure with preserved ejection fraction (HFpEF), abdominal obesity is associated with increased risk of all-cause mortality, according to a study published in the Dec. 5 issue of the Journal of the American College of Cardiology.

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Considerable Costs Incurred in Response to Single Measles Cases

MONDAY, Nov. 27, 2017 (HealthDay News) -- Single measles cases trigger coordinated public health action that is associated with considerable costs, according to research published in the Nov. 24 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Anticholinergic Cognitive Burden Scale IDs Adverse Outcomes

MONDAY, Nov. 27, 2017 (HealthDay News) -- For older adults, the Anticholinergic Cognitive Burden Scale (ACB) shows good dose-response relationships between anticholinergic burden and adverse outcomes, according to a study published in the November/December issue of the Annals of Family Medicine.

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New Workflows Have Potential to Address Provider Burnout

MONDAY, Nov. 27, 2017 (HealthDay News) -- New solutions are needed to address burnout among health care team members, yet, in a catch-22 situation for health industry leaders, change fatigue contributes to burnout, according to a Vocera Communications report entitled In Pursuit of Resilience, Well-Being, and Joy in Healthcare.

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Essay Adds to Discourse on Impact of Suggestive Jokes

MONDAY, Nov. 27, 2017 (HealthDay News) -- Seemingly benign, recurring patterns of joking around a single theme (joke cycles) can contribute to humorizing and legitimizing sexual misconduct, according to an essay published online Nov. 12 in Communication and Critical/Cultural Studies.

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Coffee Consumption Appears to Provide More Benefit Than Harm

MONDAY, Nov. 27, 2017 (HealthDay News) -- Coffee consumption seems safe and is associated with reduced risk for various health outcomes, according to a review published online Nov. 22 in The BMJ.

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History of Prior Cancer Common in Newly Diagnosed Patients

MONDAY, Nov. 27, 2017 (HealthDay News) -- A substantial number of patients diagnosed with incident cancer in the United States have a prior history of cancer, according to a brief report published online Nov. 22 in JAMA Oncology.

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Cinnamon Shows Potential As Tool in Fight Against Obesity

MONDAY, Nov. 27, 2017 (HealthDay News) -- The compound cinnamaldehyde (CA), found in cinnamon, activates fat cells to start burning energy in both mice and humans, according to a study published in the December issue of Metabolism.

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Raw Flour Can Be Source of Shiga Toxin-Producing E. coli

WEDNESDAY, Nov. 22, 2017 (HealthDay News) -- Raw flour can be a source of outbreak of Shiga toxin-producing Escherichia coli (STEC) infections, according to a study published in the Nov. 23 issue of the New England Journal of Medicine.

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Gaps Seen Between Hearing Loss, Receipt of Medical Evaluation, Tx

WEDNESDAY, Nov. 22, 2017 (HealthDay News) -- Many patients with self-reported hearing loss do not receive medical evaluation and recommended treatments, according to a study published online Nov. 22 in JAMA Otolaryngology-Head and Neck Surgery.

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NTproBNP Levels Are Significantly Lower in Blacks

WEDNESDAY, Nov. 22, 2017 (HealthDay News) -- Plasma N-terminal pro-B-type natriuretic peptide (NTproBNP) levels are significantly lower for black than white individuals, according to a study published online Nov. 22 in JAMA Cardiology.

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Female Physicians' Spouses More Likely to Work

WEDNESDAY, Nov. 22, 2017 (HealthDay News) -- Spouses of female physicians are on average more educated and work more hours outside the home than spouses of male physicians, according to a research letter published online Nov. 21 in the Annals of Internal Medicine.

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Monoclonal Antibodies Cut Ischemia-Reperfusion Injury

WEDNESDAY, Nov. 22, 2017 (HealthDay News) -- Anti-CD47 monoclonal antibody (CD47mAb) therapy reduces ischemia-reperfusion injury of renal allografts in an animal transplantation model, according to a study published online Oct. 31 in the American Journal of Transplantation.

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CDC Issues Warning on Contaminated Raw Milk

WEDNESDAY, Nov. 22, 2017 (HealthDay News) -- Individuals who may have consumed contaminated raw milk and milk products from the Udder Milk company are urged to seek medical care, according to a report published by the U.S. Centers for Disease Control and Prevention.

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Immediate Access to Opioid Agonists Found Cost-Effective

WEDNESDAY, Nov. 22, 2017 (HealthDay News) -- Immediate access to opioid agonist treatment (OAT) for patients presenting with opioid use disorder may provide greater health benefits at less cost than observed standard of care, according to a study published online Nov. 21 in the Annals of Internal Medicine.

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Baby Boomers Have Increased Risk of Rx Opioid Overdose Death

WEDNESDAY, Nov. 22, 2017 (HealthDay News) -- Individuals born between 1947 and 1964 have a significantly increased risk of prescription opioid overdose death and heroin overdose death, and those born from 1979 to 1992 also have an increased risk of heroin overdose death, according to a study published online Nov. 21 in the American Journal of Public Health.

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Workplace Sexual Harassment Ongoing in Women, Up for Men

TUESDAY, Nov. 21, 2017 (HealthDay News) -- Sexual harassment (SH) is a continuing occupational health problem, according to a report published recently in the Journal of Occupational Health Psychology.

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Insulin Doesn't Prevent Diabetes in Relatives of T1DM Patients

TUESDAY, Nov. 21, 2017 (HealthDay News) -- Oral insulin does not delay onset of type 1 diabetes in autoantibody-positive relatives of patients with type 1 diabetes, according to a study published in the Nov. 21 issue of the Journal of the American Medical Association.

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High Costs Associated With Physician Burnout, Attrition

TUESDAY, Nov. 21, 2017 (HealthDay News) -- Physicians who are experiencing burnout are more than twice as likely to leave their organization within two years, and this is associated with significant economic costs, according to a report from the American Medical Association.

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Doubts Raised About Use of Products Containing Oxybenzone

TUESDAY, Nov. 21, 2017 (HealthDay News) -- Use of oxybenzone (Benzophenone-3) in sunscreen and personal care products should be minimized due to its dermatological and environmental toxicity, according to a review published online Oct. 31 in the Journal of Cosmetic Dermatology.

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Increased Repolarization Dispersion Seen in SCD Survivors

TUESDAY, Nov. 21, 2017 (HealthDay News) -- Survivors of sudden cardiac death (SCD) with structurally normal hearts have increased dispersion of repolarization after exertion, and this is detectable on non-invasive electrocardiographic imaging (ECGi), according to a study published online Nov. 1 in the Journal of Cardiovascular Electrophysiology.

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Higher β-Blocker Dose Linked to Lower Mortality Risk

TUESDAY, Nov. 21, 2017 (HealthDay News) -- An increased β-blocker dose is associated with a greater prognostic advantage in patients with chronic heart failure (CHF) and diabetes than in those with CHF but no diabetes, according to a study published online Oct. 25 in Diabetes Care.

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Best Practice Advice Issued for Hep B Vaccination, Screening

TUESDAY, Nov. 21, 2017 (HealthDay News) -- Best practice advice statements from the American College of Physicians and the U.S. Centers for Disease Control and Prevention, published online Nov. 21 in the Annals of Internal Medicine, encourage hepatitis B virus (HBV) screening in high-risk populations, vaccination of all unvaccinated at-risk adults, and linkage to care for HBV-positive patients.

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Stool-Based Protein Combos Can Improve CRC Screening

TUESDAY, Nov. 21, 2017 (HealthDay News) -- Combinations of four proteins from stool samples can detect colorectal cancer (CRC) and advanced adenomas with higher sensitivity than hemoglobin alone, according to a study published online Nov. 21 in the Annals of Internal Medicine.

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NOACs Show Lower Risk of Adverse Renal Outcomes in A-Fib

TUESDAY, Nov. 21, 2017 (HealthDay News) -- For patients with atrial fibrillation (AF), non-vitamin K antagonist oral anticoagulants (NOACs) are associated with lower risks of adverse renal outcomes than warfarin, according to a study published in the Nov. 28 issue of the Journal of the American College of Cardiology.

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No Treatment or Imaging Follow-Up Most Effective for Tiny UIAs

TUESDAY, Nov. 21, 2017 (HealthDay News) -- For patients with unruptured intracranial aneurysms (UIAs) that are 3 mm or smaller, no preventive treatment or imaging follow-up is the most effective management strategy, according to a study published online Nov. 20 in JAMA Neurology.

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Few U.S. Adults Meet Fruit, Veg Intake Recommendations

TUESDAY, Nov. 21, 2017 (HealthDay News) -- Across all 50 states and the District of Columbia (D.C.), few adults consume the recommended amount of fruits and vegetables, according to research published in the Nov. 17 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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NAFLD Linked to Smaller Total Cerebral Brain Volume

MONDAY, Nov. 20, 2017 (HealthDay News) -- Nonalcoholic fatty liver disease (NAFLD) is associated with smaller total cerebral brain volume, according to a study published online Nov. 20 in JAMA Neurology.

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High Salt Intake Impacts Gut Microbiome

MONDAY, Nov. 20, 2017 (HealthDay News) -- High salt intake affects the gut microbiome; however, certain intestinal bacteria may help prevent high-salt diets contributing to hypertension, according to research published online Nov. 15 in Nature.

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Certain Traits Tied to More HIV Tests in Transgender Individuals

MONDAY, Nov. 20, 2017 (HealthDay News) -- Transgender individuals with certain characteristics, including a history of incarceration and self-referral, have more HIV tests, according to a short report published in Transgender Health.

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Spinal Cord Stimulation May Reduce Neuropathic Pain

MONDAY, Nov. 20, 2017 (HealthDay News) -- Spinal cord stimulation (SCS) effectively reduces chronic pain symptoms in individuals with painful diabetic polyneuropathy (PDPN), according to a study published online Nov. 6 in Diabetes Care.

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Brain Glucose Responses Diminish With Diabetes, Obesity

MONDAY, Nov. 20, 2017 (HealthDay News) -- The rise of brain glucose levels is blunted during hyperglycemia in adults with obesity and type 2 diabetes mellitus (T2DM), according to a study published online Oct. 19 in JCI Insight.

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Attributes of High-Value Primary Care Identified

MONDAY, Nov. 20, 2017 (HealthDay News) -- Six statistically significant attributes of high-value primary care have been identified, and they include decision support for evidence-based medicine, risk-stratified care management, and coordination of care, according to a study published in the November/December issue of the Annals of Family Medicine.

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NAFLD Linked to Increased Cancer Incidence Rate

MONDAY, Nov. 20, 2017 (HealthDay News) -- Non-alcoholic fatty liver disease (NAFLD) is associated with development of cancer, specifically hepatocellular carcinoma (HCC), colorectal cancer in males, and breast cancer in females, according to a study published online Nov. 14 in the Journal of Hepatology.

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SMS Reminders Moderately Effective for Flu Vaccination

MONDAY, Nov. 20, 2017 (HealthDay News) -- Short message service (SMS) reminders are a moderately effective way to increase the rate of influenza vaccination among high-risk patients, according to a study published in the November/December issue of the Annals of Family Medicine.

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Many Health Care Providers Work While Sick

FRIDAY, Nov. 17, 2017 (HealthDay News) -- More than 40 percent of health care personnel (HCP) with influenza-like illness (ILI) work while ill, according to a study published in the November issue of the American Journal of Infection Control.

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Intensive BP Control Lacks Benefit in Chronic Kidney Disease

FRIDAY, Nov. 17, 2017 (HealthDay News) -- Intensive blood pressure (BP) control may provide no benefit and may even be harmful for patients with moderate-to-advanced chronic kidney disease, according to a study published online Oct. 16 in the Journal of Internal Medicine.

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Simple Checklist Can Identify Useful Clinical Practice Guidelines

FRIDAY, Nov. 17, 2017 (HealthDay News) -- A simple, easy-to-use checklist, the Guideline Trustworthiness, Relevance, and Utility Scoring Tool (G-TRUST), can identify useful clinical practice guidelines, according to a study published in the September/October issue of the Annals of Family Medicine.

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First-Line Metformin Use for DM Up; Sulfonylurea Use Down

FRIDAY, Nov. 17, 2017 (HealthDay News) -- Among patients with type 2 diabetes initiating antidiabetes drugs (ADDs), first-line use of metformin has increased since 2005, while sulfonylureas have remained the most popular second-line agent, according to a study published online Nov. 6 in Diabetes Care.

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Allopurinol Has Little Benefit in Cardiac Syndrome X

FRIDAY, Nov. 17, 2017 (HealthDay News) -- Allopurinol does not appear to improve exercise capacity or peripheral endothelial or coronary function in patients with cardiac syndrome X, according to a study published online Oct. 28 in Cardiovascular Therapeutics.

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Erlotinib Overdose Tied to Conjunctivitis

FRIDAY, Nov. 17, 2017 (HealthDay News) -- Overdosing of erlotinib may be associated with rapid onset of conjunctivitis, according to a case report published online Oct. 25 in the Journal of Clinical Pharmacy and Therapeutics.

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Docs' Preparedness Influences Exercise Recommendations

FRIDAY, Nov. 17, 2017 (HealthDay News) -- Primary care providers who feel prepared are more likely to recommend physical activity to patients with disabilities, according to a study published online Nov. 16 in Preventing Chronic Disease.

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AMD Risk Has Dropped By Birth Cohort Throughout 20th Century

FRIDAY, Nov. 17, 2017 (HealthDay News) -- There was a decrease in the five-year risk for age-related macular degeneration (AMD) by birth cohorts throughout the 20th century, according to a study published online Nov. 16 in JAMA Ophthalmology.

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Risk of Falls Up With Mild, Moderate Diabetic Retinopathy

FRIDAY, Nov. 17, 2017 (HealthDay News) -- Among Asians, individuals with mild and moderate diabetic retinopathy (DR) are more likely to have fallen, and greater perceived barriers to diabetes self-management (DSM) are associated with the severity of DR, according to two studies published online Nov. 16 in JAMA Ophthalmology.

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FDA OKs Drug for Hemophilia A With Factor VIII Inhibitors

FRIDAY, Nov. 17, 2017 (HealthDay News) -- Hemlibra (emicizumab-kxwh) has been approved by the U.S. Food and Drug Administration to prevent or reduce the frequency of bleeding episodes among hemophilia A patients with Factor VIII inhibitors.

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Virtual Reality Effective for Post-Stroke Upper Extremity Rehab

THURSDAY, Nov. 16, 2017 (HealthDay News) -- Virtual reality (VR) training is as effective as conventional training for upper extremity rehabilitation after stroke, according to a study published online Nov. 15 in Neurology.

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Model Predicts Development of Chronic Kidney Disease

THURSDAY, Nov. 16, 2017 (HealthDay News) -- A multivariable model that uses routine laboratory data is able to predict advanced chronic kidney disease after hospitalization with acute kidney injury, according to a study published online Nov. 14 in the Journal of the American Medical Association.

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Simpler Tool Promising for Atherosclerosis Prediction

THURSDAY, Nov. 16, 2017 (HealthDay News) -- The ideal cardiovascular health score (ICHS) and the Fuster-BEWAT (blood pressure, exercise, weight, alimentation, and tobacco) score (FBS) are similar in their ability to predict subclinical atherosclerosis, according to a study published online Nov. 13 in the Journal of the American College of Cardiology.

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FDA Approves Drug With Digital Ingestion Tracking System

WEDNESDAY, Nov. 15, 2017 (HealthDay News) -- The first drug in the United States with a digital ingestion tracking system has been approved by the U.S. Food and Drug Administration.

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Insurance Underlies Black-White Survival Disparity in CRC

WEDNESDAY, Nov. 15, 2017 (HealthDay News) -- Insurance coverage differences account for about half of the disparity in survival rates between black and white patients aged 18 to 64 years with colorectal cancer (CRC), according to a study published online Nov. 14 in Gastroenterology.

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ER- Breast CA Risk Up for African-Americans With T2DM

WEDNESDAY, Nov. 15, 2017 (HealthDay News) -- African-American (AA) women with type 2 diabetes (T2D) appear to be at increased risk of developing estrogen receptor-negative (ER-) breast cancer, with the highest risk among nonobese individuals, according to a study published online Nov. 15 in Cancer Research.

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In 2007-2014, Glycemic Control Plateaued in Diabetes Patients

WEDNESDAY, Nov. 15, 2017 (HealthDay News) -- Despite increases in HbA1c testing and awareness, glycemic control seems to have plateaued among patients with diabetes between 2007 and 2014, according to a research letter published online Nov. 14 in the Journal of the American Medical Association.

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Health Care Experts in Favor of Patient Contribution to Notes

WEDNESDAY, Nov. 15, 2017 (HealthDay News) -- Health care experts are supportive of OurNotes, an intervention in which patients and families co-produce medical notes with clinicians, according to a research letter published online Nov. 13 in the Annals of Internal Medicine.

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PCP Care in Hospital Linked to Resource Use, Outcome

WEDNESDAY, Nov. 15, 2017 (HealthDay News) -- Patients cared for in the hospital by their own primary care physician (PCP) have longer length of stay and are more likely to be discharged home than those cared for by hospitalists or other generalists, according to a study published online Nov. 13 in JAMA Internal Medicine.

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Poorer Neuropsychological Test Scores for HIV-Positive

WEDNESDAY, Nov. 15, 2017 (HealthDay News) -- HIV-positive individuals treated with combination antiretroviral therapy (cART) have poorer neuropsychological test scores than controls but no significant neuropsychological decline over time, according to a study published online Nov. 13 in JAMA Neurology.

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Findings Support Endovascular Repair of Aortic Aneurysm

WEDNESDAY, Nov. 15, 2017 (HealthDay News) -- For patients with suspected ruptured abdominal aortic aneurysm, endovascular repair is associated with a survival advantage at three years compared with open repair, according to a study published online Nov. 14 in the BMJ.

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AHA: Noninvasive Testing Ups LOS in Patients With Chest Pain

WEDNESDAY, Nov. 15, 2017 (HealthDay News) -- Noninvasive cardiac testing leads to longer length of stay (LOS) for patients presenting to the emergency department with chest pain, according to a study published online Nov. 14 in JAMA Internal Medicine to coincide with the American Heart Association's Scientific Sessions, being held Nov. 11 to 15 in Anaheim, California.

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XR Naltrexone, Sublingual BUP-NX Deemed Equally Effective

WEDNESDAY, Nov. 15, 2017 (HealthDay News) -- Although initiation of extended-release naltrexone (XR-NTX) may be more difficult, XR-NTX and sublingual buprenorphine-naloxone (BUP-NX) are equally safe and effective once initiated for opioid relapse prevention, according to a study published online Nov. 14 in The Lancet.

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Eating More Nuts Associated With Lower Heart Disease Risk

TUESDAY, Nov. 14, 2017 (HealthDay News) -- Nut consumption is tied to a decreased risk of cardiovascular disease and coronary heart disease (CHD), according to a study published online Nov. 13 in the Journal of the American College of Cardiology.

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Perioperative Aspirin May Benefit Patients With Prior PCI

TUESDAY, Nov. 14, 2017 (HealthDay News) -- For patients with prior percutaneous coronary intervention (PCI), perioperative aspirin seems to be beneficial, according to a study published online Nov. 13 in the Annals of Internal Medicine.

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LRRK2 Variants Linked to Lower Age at Onset of Parkinson's

TUESDAY, Nov. 14, 2017 (HealthDay News) -- The presence of multiple LRRK2 risk variants is associated with a younger age at onset (AAO) of Parkinson's disease (PD), according to a research letter published online Nov. 13 in JAMA Neurology.

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Outcomes for Atrial Fibrillation Similar With Dabigatran, Warfarin

TUESDAY, Nov. 14, 2017 (HealthDay News) -- In clinical practice, patients starting dabigatran therapy do not have significantly different rates of ischemic stroke or extracranial hemorrhage than those starting warfarin therapy, though they have lower rates of intracranial bleeding, according to a study published online Nov. 13 in the Annals of Internal Medicine.

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More Laboratory Tests Performed at Major Teaching Hospitals

TUESDAY, Nov. 14, 2017 (HealthDay News) -- For inpatients with a primary diagnosis of bacterial pneumonia or cellulitis, significantly more laboratory tests are performed per day at major teaching hospitals versus nonteaching hospitals, according to a study published online Nov. 13 in JAMA Internal Medicine.

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Leisure Time Exercise Linked to Reduced Mortality in T1DM

TUESDAY, Nov. 14, 2017 (HealthDay News) -- For patients with type 1 diabetes, including those with chronic kidney disease (CKD), leisure-time physical activity (LTPA) is associated with reduced risk of all-cause mortality, according to a study published online Oct. 16 in Diabetes Care.

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Outbreaks Linked to Drinking Water Mainly Due to Legionella

TUESDAY, Nov. 14, 2017 (HealthDay News) -- Most drinking water-associated waterborne disease outbreaks and waterborne disease outbreaks associated with environmental or undetermined exposure to water are due to Legionella, according to two studies published online Nov. 9 in Morbidity and Mortality Weekly Report.

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Oral Chemotherapy Parity Laws Offer Some Financial Protection

MONDAY, Nov. 13, 2017 (HealthDay News) -- The adoption of state oral chemotherapy parity laws has improved financial protection for many patients, according to a study published online Nov. 9 in JAMA Oncology.

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Soluble Interleukin 2 Receptor IDs Sarcoidosis in Uveitis

MONDAY, Nov. 13, 2017 (HealthDay News) -- Soluble interleukin 2 receptor (sIL-2R) has slightly better diagnostic value than angiotensin-converting enzyme (ACE) for sarcoidosis in patients with uveitis, according to a study published online Nov. 9 in JAMA Ophthalmology.

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Use of MMR Deficiency Testing in Younger CRC Patients Is Low

MONDAY, Nov. 13, 2017 (HealthDay News) -- Fewer than half of younger adults with colorectal cancer (CRC) undergo mismatch repair (MMR) deficiency of DNA testing, according to a study published online Nov. 9 in JAMA Oncology.

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About 20 Percent of U.S. Adults Currently Use Tobacco Products

MONDAY, Nov. 13, 2017 (HealthDay News) -- About one in five U.S. adults currently uses any tobacco product, according to a study published online Nov. 9 in Morbidity and Mortality Weekly Report.

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Cardiac Index Linked to Cerebral Blood Flow Regardless of CVD

MONDAY, Nov. 13, 2017 (HealthDay News) -- Among older adults, lower cardiac index is associated with lower resting cerebral blood flow (CBF) in the temporal lobes regardless of cardiovascular disease (CVD) but is not associated with cerebrovascular reactivity (CVR), according to a study published online Nov. 8 in Neurology.

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Short PCP Consultation Length Seen Worldwide

THURSDAY, Nov. 9, 2017 (HealthDay News) -- There is considerable global variation in the average primary care physician consultation length, from 48 seconds to 22.5 minutes, according to a review published online Nov. 8 in BMJ Open.

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Breast Cancer Recurrences Steady After Therapy Cessation

THURSDAY, Nov. 9, 2017 (HealthDay News) -- When adjuvant endocrine therapy for estrogen receptor-positive breast cancer is stopped after five years, recurrences occur at a steady rate into the future, according to a meta-analysis published online Nov. 8 in the New England Journal of Medicine.

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Online CBT Program Beneficial for Depression, Anxiety

THURSDAY, Nov. 9, 2017 (HealthDay News) -- For patients with depression and anxiety, online computerized cognitive behavioral therapy (CCBT) provided via a collaborative care program is beneficial, but combining an internet support group (ISG) with CCBT offers no additional benefit, according to a study published online Nov. 8 in JAMA Psychiatry.

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Adding Exercise to Compression Therapy Promising for Leg Ulcers

THURSDAY, Nov. 9, 2017 (HealthDay News) -- Supervised exercise training in conjunction with compression may improve outcomes for patients with venous leg ulcers (VLUs), according to a study published online Oct. 27 in the British Journal of Dermatology.

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CPAP May Be Superior to Gastric Banding for Severe Sleep Apnea

THURSDAY, Nov. 9, 2017 (HealthDay News) -- Continuous positive airway pressure (CPAP) may be a more effective treatment than laparoscopic gastric banding (LGB) for control of severe obstructive sleep apnea (OSA), according to a study published online Oct. 16 in the American Journal of Respiratory and Critical Care Medicine.

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Doctors Have Extra Two Weeks to Preview Performance Data

WEDNESDAY, Nov. 8, 2017 (HealthDay News) -- Physicians have two extra weeks to preview their 2016 performance information as a result of a mistake related to the Centers for Medicare & Medicaid Services' Physician Compare online resource, according to a report published by the American Academy of Family Physicians.

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ASCO Issues Statement Regarding Alcohol and Cancer

WEDNESDAY, Nov. 8, 2017 (HealthDay News) -- Alcohol use is associated with certain types of cancer, and the risk of cancer can be reduced by strategies to prevent excessive use of alcohol, according to a statement published online Nov. 7 in the Journal of Clinical Oncology.

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Delay in Tranexamic Acid Administration Reduces Benefit

WEDNESDAY, Nov. 8, 2017 (HealthDay News) -- For patients with acute severe bleeding, any delay in treatment with tranexamic acid is associated with a reduction in the survival benefit, according to a meta-analysis published online Nov. 7 in The Lancet.

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Sodium Oxybate Promising for Parkinson's, Daytime Sleepiness

WEDNESDAY, Nov. 8, 2017 (HealthDay News) -- For patients with Parkinson's disease (PD) and excessive daytime sleepiness (EDS), sodium oxybate seems effective and well-tolerated, according to a study published online Nov. 6 in JAMA Neurology.

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Glycosylation Differences in Egg-Adapted Vaccines May Cut Impact

WEDNESDAY, Nov. 8, 2017 (HealthDay News) -- Differences in glycosylation between H3N2 egg-adapted vaccines and circulating strains probably reduced vaccine effectiveness during the 2016-2017 influenza season, according to a study published online Nov. 6 in the Proceedings of the National Academy of Sciences.

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Drop in Incidence of End-Stage Renal Disease Due to Diabetes

WEDNESDAY, Nov. 8, 2017 (HealthDay News) -- The incidence of end-stage renal disease (ESRD) with diabetes listed as the primary cause (ESRD-D) decreased across the United States from 2000 to 2014, according to a study published online Nov. 2 in Morbidity and Mortality Weekly Report.

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In ER, Combination of Ibuprofen, Acetaminophen Relieves Pain

WEDNESDAY, Nov. 8, 2017 (HealthDay News) -- For patients presenting to the emergency department with acute extremity pain, the combination of ibuprofen and acetaminophen does not differ in terms of pain reduction from three different opioid and acetaminophen combination analgesics, according to a study published online Nov. 7 in the Journal of the American Medical Association.

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Lymphoma Risk Up With Thiopurine, Anti-TNF Tx in IBD

WEDNESDAY, Nov. 8, 2017 (HealthDay News) -- For patients with inflammatory bowel disease (IBD), the risk of lymphoma is increased with use of thiopurine monotherapy, anti-tumor necrosis factor (TNF) monotherapy, and combination therapy, according to a study published online Nov. 7 in the Journal of the American Medical Association.

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Evidence Scant for Treatment of Cough With the Common Cold

WEDNESDAY, Nov. 8, 2017 (HealthDay News) -- There has been little change in the treatment recommendations for cough due to the common cold since publication of guidelines in 2006, according to a review published online Nov. 7 in Chest.

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Increases in U.S. Health Spending Tied to Health Service Price

WEDNESDAY, Nov. 8, 2017 (HealthDay News) -- Factors including increases in health care service price and intensity are associated with increases in U.S. health care spending from 1996 to 2013, according to a study published online Nov. 7 in the Journal of the American Medical Association.

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USPSTF Posts Osteoporosis Screening Recommendations

TUESDAY, Nov. 7, 2017 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) draft recommendation statement and draft evidence review on Screening for Osteoporosis to Prevent Osteoporotic Fractures have been posted for public comment through Dec. 4, 2017.

Draft Recommendation Statement
Draft Evidence Review

Cannabidiol Concentration Varies Widely in Online Products

TUESDAY, Nov. 7, 2017 (HealthDay News) -- Among cannabidiol (CBD) products sold online, there is a wide range of CBD concentrations, and many products are under- or overlabeled, according to a research letter published online Nov. 7 in the Journal of the American Medical Association.

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Exercise, Intervention Combos Associated With Lower Fall Risk

TUESDAY, Nov. 7, 2017 (HealthDay News) -- For older adults, exercise alone and combinations of interventions are associated with reduced risk of injurious falls, according to a review published online Nov. 6 in the Journal of the American Medical Association.

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Warfarin Use Linked to Reduced Incidence of Cancer

TUESDAY, Nov. 7, 2017 (HealthDay News) -- For adults older than 50 years, warfarin use is associated with reduced incidence of cancer, according to a study published online Nov. 6 in JAMA Internal Medicine.

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Intensity of Exercise Affects Impact on Mortality Risk

TUESDAY, Nov. 7, 2017 (HealthDay News) -- Total physical activity (PA) and moderate- to vigorous-intensity PA (MVPA) are inversely associated with mortality, though light-intensity PA and sedentary behavior are not associated with mortality, according to a research letter published online Nov. 6 in Circulation.

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Rates of IVC Filter Placement Decreased from 2010 to 2014

TUESDAY, Nov. 7, 2017 (HealthDay News) -- The rates of inferior vena cava (IVC) filter placement increased from 2005 until 2010 and then decreased through 2014, according to a research letter published online Nov. 6 in JAMA Internal Medicine.

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Sertraline Treatment No Benefit for Depressive Symptoms in CKD

TUESDAY, Nov. 7, 2017 (HealthDay News) -- Sertraline treatment does not significantly improve depressive symptoms among patients with non-dialysis-dependent chronic kidney disease (CKD) and major depressive disorder (MDD), according to a study published online Nov. 3 in the Journal of the American Medical Association.

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Legal Aspects to Consider in Voluntary Refusal to Eat, Drink

TUESDAY, Nov. 7, 2017 (HealthDay News) -- Voluntarily stopping eating and drinking (VSED) is a course that patients may choose to hasten their death, although there are clinical, ethical, and legal aspects to consider, according to a special communication published online Nov. 6 in JAMA Internal Medicine.

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Lifestyle Changes Successfully Reduce Incidence of Diabetes

TUESDAY, Nov. 7, 2017 (HealthDay News) -- Lifestyle modification (LSM) and medications can reduce the incidence of diabetes in adults at risk, although the effects of medications are short-lived, according to a review published online Nov. 6 in JAMA Internal Medicine.

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Completion Likely With Self-Administration of TB Treatment

TUESDAY, Nov. 7, 2017 (HealthDay News) -- Most people complete treatment for latent tuberculosis (TB) without direct observation, according to a study published online Nov. 6 in the Annals of Internal Medicine.

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PCI Does Not Improve Exercise Time in Angina Patients

MONDAY, Nov. 6, 2017 (HealthDay News) -- Percutaneous coronary intervention (PCI) does not increase exercise time more than a placebo procedure in patients with medically treated angina and severe coronary stenosis, according to a study published online Nov. 2 in The Lancet.

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Fiber Tied to Lower Mortality in Those With Colorectal Cancer

MONDAY, Nov. 6, 2017 (HealthDay News) -- Higher fiber intake after a diagnosis of nonmetastatic colorectal cancer (CRC) is associated with lower CRC-specific and overall mortality, according to a study published online Nov. 2 in JAMA Oncology.

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Novel Method Developed for Estimating Prevalence of Diabetes

MONDAY, Nov. 6, 2017 (HealthDay News) -- A novel method has been developed to enhance the prevalence estimates of diabetes and prediabetes, according to a study published online Nov. 2 in Preventing Chronic Diseases.

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Postmenopausal Estradiol Linked to Blunted Cortisol Responses

THURSDAY, Nov. 2, 2017 (HealthDay News) -- Postmenopausal estradiol therapy (ET) may protect certain types of cognition in the presence of stress, according to a study published online Nov. 2 in the Journal of Clinical Endocrinology & Metabolism.

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Pricing Interventions Increase Sales, Intake of Healthy Foods

FRIDAY, Nov. 3, 2017 (HealthDay News) -- Pricing interventions seem to improve access to healthy food and beverage options with increases in stocking and sales of these items, according to a review published online Nov. 2 in Preventing Chronic Disease.

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Novel Artificial Pancreas Cuts HbA1c, Hypoglycemia in T1DM

FRIDAY, Nov. 3, 2017 (HealthDay News) -- A novel adaptive artificial pancreas (AP) can reduce hemoglobin A1c (HbA1c) in adults with type 1 diabetes (T1D), according to a study published online Oct. 13 in Diabetes Care.

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CYP2C19-Genotype Guided Antiplatelet Tx May Be Beneficial

FRIDAY, Nov. 3, 2017 (HealthDay News) -- Patients with a CYP2C19 loss-of-function allele have increased risk of major adverse cardiovascular events (MACE) with clopidogrel versus alternative antiplatelet therapy after percutaneous coronary intervention (PCI), according to a study published online Nov. 1 in JACC: Cardiovascular Interventions.

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Favorable Prognosis for Syncope Patients Discharged From ER

THURSDAY, Nov. 2, 2017 (HealthDay News) -- Most patients presenting to the emergency department (ED) with a primary diagnosis of syncope are discharged and have a favorable prognosis, and though total costs to care for discharged syncope patients are high, cost per patient is lower compared with hospitalized patients, according to a study published online Nov. 1 in JACC: Clinical Electrophysiology.

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Prescription-Strength Steroids Sold Without Prescription

THURSDAY, Nov. 2, 2017 (HealthDay News) -- The ability to purchase a product containing a class 3 topical steroid online, without physician authorization, highlights the dangers of prescription-strength medications being acquired as over-the-counter products, according to a research letter published online Nov. 1 in JAMA Dermatology.

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Race a Factor in Intracranial Atherosclerotic Disease

THURSDAY, Nov. 2, 2017 (HealthDay News) -- Black men have increased prevalence and frequency of multiple intracranial atherosclerotic plaques, according to a study published online Nov. 1 in JAMA Cardiology.

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Nutritional Therapy Beneficial in Chronic Kidney Disease

THURSDAY, Nov. 2, 2017 (HealthDay News) -- Nutritional interventions may be beneficial for the management of chronic kidney disease in adults, according to a review article published online Nov. 1 in the New England Journal of Medicine.

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Midlife Systemic Inflammation Tied to Late-Life Brain Volume

THURSDAY, Nov. 2, 2017 (HealthDay News) -- Systemic inflammation in midlife is associated with future neurodegeneration and cognitive aging, according to a study published online Nov. 1 in Neurology.

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Liposuction Can Reduce Lymphedema-Related Swelling

THURSDAY, Nov. 2, 2017 (HealthDay News) -- Liposuction may be beneficial for patients with lymphedema, according to a research letter published online Nov. 1 in the New England Journal of Medicine.

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GLP-1 May Mediate Effects of Gastric Bypass on CNS Activation

THURSDAY, Nov. 2, 2017 (HealthDay News) -- The central effects of glucagon-like peptide-1 (GLP-1) may mediate the effects of Roux-en-Y gastric bypass (RYGB) on central nervous system (CNS) activation in response to visual and gustatory food cues, according to a study published online Oct. 12 in Diabetes Care.

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Driving Impairment Warnings Often Not Given With Rx Meds

THURSDAY, Nov. 2, 2017 (HealthDay News) -- Not all prescription drug users report receiving warnings about driving impairment, according to a study published online Nov. 1 in the Journal of Studies on Alcohol and Drugs.

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RA Associated With Higher Risk of COPD Hospitalization

WEDNESDAY, Nov. 1, 2017 (HealthDay News) -- Individuals with rheumatoid arthritis (RA) have an increased risk of incident chronic obstructive pulmonary disease (COPD) hospitalization compared with those in the general population, according to a study published online Oct. 19 in Arthritis Care & Research.

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Promising Pneumonia Vaccine Under Development

WEDNESDAY, Nov. 1, 2017 (HealthDay News) -- A pneumonia vaccine under development provides the "most comprehensive coverage" to date and alleviates antimicrobial concerns, according to a study published online Oct. 18 in Science Advances.

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CMS Launches Initiative to Examine Impact of Regulations

WEDNESDAY, Nov. 1, 2017 (HealthDay News) -- The Centers for Medicare & Medicaid Services (CMS) has launched an initiative to examine which provider regulations should be discarded or revamped amid concerns that the regulations are reducing the amount of time that physicians spend with patients, according to an article published in Modern Healthcare.

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PPI-Gastric Cancer Link Remains After H. Pylori Eradication

WEDNESDAY, Nov. 1, 2017 (HealthDay News) -- Long-term proton pump inhibitor (PPI) use is associated with increased risk of gastric cancer (GC) even after Helicobacter pylori (HP) eradication therapy, according to a study published online Oct. 31 in Gut.

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Updated Guidelines Released for Ventricular Arrhythmias

WEDNESDAY, Nov. 1, 2017 (HealthDay News) -- The American College of Cardiology, the American Heart Association, and the Heart Rhythm Society have released updated guidelines for the management of adults who have ventricular arrhythmias (VAs) or who are at risk for sudden cardiac death (SCD). The guidelines were published online Oct. 30 in the Journal of the American College of Cardiology.

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Enjoyment of Spicy Food May Lower Salt Preference, Intake

WEDNESDAY, Oct. 31, 2017 (HealthDay News) -- Enjoyment of spicy food seems to reduce individual salt preference, salt intake, and blood pressure, according to research published online Oct. 31 in Hypertension.

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Dry Mouth Common Medication Reaction in Older Adults

WEDNESDAY, Nov. 1, 2017 (HealthDay News) -- In older adults, medication use is significantly associated with xerostomia and salivary gland dysfunction, according to a review published online Oct. 26 in the Journal of the American Geriatrics Society.

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Two Simple Tests Can ID Fibromyalgia in Pain Patients

WEDNESDAY, Nov. 1, 2017 (HealthDay News) -- Two simple tests can indicate a probable diagnosis of fibromyalgia (FM) in patients with chronic pain, according to a study published online Oct. 23 in the Journal of Evaluation in Clinical Practice.

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Magnesium, T2DM Link Seen in Poor-Carbohydrate-Quality Diet

WEDNESDAY, Nov. 1, 2017 (HealthDay News) -- The correlation between higher magnesium intake and reduced risk of type 2 diabetes is stronger in the context of poor-carbohydrate-quality diets, according to a study published online Oct. 4 in Diabetes Care.

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Hepatitis B Viral Load, Surface Antigen May ID Liver Cancer Risk

WEDNESDAY, Nov. 1, 2017 (HealthDay News) -- Elevated levels of hepatitis B virus (HBV) DNA and hepatitis B surface antigen (HBsAg) are associated with increased risks of liver cancer, according to a study published online Oct. 24 in the Journal of Gastroenterology and Hepatology.

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