November 2016 Briefing - Pharmacy

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Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for November 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Levels of Total, LDL Cholesterol Continue to Fall in the U.S.

WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- Healthier diets may be a factor in the ongoing decline in cholesterol levels for Americans, according to a research letter published online Nov. 30 in JAMA Cardiology.

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No Link for Maternal Flu Infection, Increased ASD Risk

WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- Maternal influenza infection during pregnancy is not associated with increased risk of autism spectrum disorder (ASD), according to a study published online Nov. 28 in JAMA Pediatrics.

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Meta-Analysis: Statins Cut Risk of Advanced Colorectal Adenoma

WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- Statins seem not to be associated with the risk of colorectal adenoma, but are associated with reduced risk of advanced adenoma, according to a review and meta-analysis published online Nov. 23 in the Journal of Gastroenterology and Hepatology.

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Preemies Often Receive Gastroesophageal Reflux Meds

WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- Thirty-seven percent of premature infants receive gastroesophageal reflux (GER) medications, with more than three-quarters initiating medication use after discharge from the neonatal intensive care unit (NICU), according to a study published online Nov. 23 in Pediatrics.

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E-Prescribing of High-Risk Drugs May Contribute to Falls in Elderly

TUESDAY, Nov. 29, 2016 (HealthDay News) -- Preprogrammed doses of medications that can raise the risk of falls are often set too high for older hospital patients, according to research published online Nov. 28 in the Journal of the American Geriatrics Society.

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As Prices Soar, ADA Calls for Access to Affordable Insulin

TUESDAY, Nov. 29, 2016 (HealthDay News) -- In early November, Sen. Bernie Sanders, the Vermont Democrat, pointed out that certain insulins had risen from $21 a vial in 1996 to $255 a vial in 2016.

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Clinical Practice Guideline on UTI in Febrile Young Reaffirmed

TUESDAY, Nov. 29, 2016 (HealthDay News) -- The 2011 clinical practice guideline (CPG) on urinary tract infection (UTI) in young children has been reaffirmed, according to a report published online Nov. 28 in Pediatrics.

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Renal Outcomes Up With BP <120/70 in T1DM

TUESDAY, Nov. 29, 2016 (HealthDay News) -- For patients with type 1 diabetes, blood pressure (BP) of <120/70 mm Hg is associated with a substantially reduced risk of adverse renal outcomes, according to a study published online Nov. 21 in Diabetes Care.

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Older Fallers Have Often Been Administered High-Risk Drugs

MONDAY, Nov. 28, 2016 (HealthDay News) -- Older fallers have often been administered high-risk medications, frequently at higher-than-recommended doses, according to a study published online Nov. 28 in the Journal of the American Geriatrics Society.

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Recommended Tx Adherence Low in Pediatric Acute Seizure

MONDAY, Nov. 28, 2016 (HealthDay News) -- For pediatric patients transported for an acute seizure, adherence to recommended treatment is poor, according to a study published online Nov. 23 in Pediatrics.

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Out-of-Pocket Cancer Costs High for Patients With Medicare Only

MONDAY, Nov. 28, 2016 (HealthDay News) -- Medical bills for older U.S. cancer patients can cost one-quarter of their income or more if they have Medicare without supplemental insurance, according to a study published online Nov. 23 in JAMA Oncology.

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Rapid, Clinically Meaningful Psoriasis Relief With Ixekizumab

MONDAY, Nov. 28, 2016 (HealthDay News) -- For patients with psoriasis, ixekizumab is associated with significant improvements in psoriasis symptoms, with itch severity improvements seen as early as week one, according to a study published in the December issue of the Journal of American Academy of Dermatology.

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In Acetaminophen-Induced Acute Liver Failure, FABP1 IDs Mortality

MONDAY, Nov. 28, 2016 (HealthDay News) -- Serum liver-type fatty acid binding protein (FABP1) early (day one) or late (day three to five) levels are associated with mortality in patients with acetaminophen (APAP)-induced acute liver failure (ALF), according to a study published online Nov. 18 in Hepatology.

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Liraglutide Doesn't Affect Gastric Emptying in Type 1 Diabetes

MONDAY, Nov. 28, 2016 (HealthDay News) -- For individuals with type 1 diabetes mellitus (T1DM), liraglutide therapy does not affect the rate of gastric emptying (GE) during hypoglycemia, according to a study published online Nov. 21 in Diabetes, Obesity and Metabolism.

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ADT Use Not Linked to Dementia in Prostate Cancer

MONDAY, Nov. 28, 2016 (HealthDay News) -- For men with prostate cancer, use of androgen deprivation therapy (ADT) seems not to be associated with dementia, according to a study published online Nov. 21 in the Journal of Clinical Oncology.

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Review Links PPI Use With Risk of Fundic Gland Polyps

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- Long-term proton pump inhibitor (PPI) use is associated with increased risk of fundic gland polyps (FGPs), and may be associated with gastric cancer, according to a review published in the December issue of Clinical Gastroenterology and Hepatology.

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Only Two Doses of HPV Vaccine Necessary for Younger Teens

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- Two doses of the human papillomavirus (HPV) vaccine, rather than three, can effectively protect younger teens against the virus, according to a study published online Nov. 21 in the Journal of the American Medical Association. The study was one of a number evaluated by the U.S. Centers for Disease Control and Prevention earlier this year, which led to the CDC's revised guidelines in October.

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Mortality Rate From Infectious Diseases Holding Steady in U.S.

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- The U.S. mortality rate from infectious diseases is about the same now as it was in 1980, but some of the specific disease threats have changed over the years, according to a research letter published in the Nov. 22/29 issue of the Journal of the American Medical Association.

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Increased Cost of CLL Tx Poses Considerable Financial Burden

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- For patients with chronic lymphocytic leukemia (CLL), survival is projected to increase by 2025, and the corresponding cost of care will increase considerably, according to a study published online Nov. 21 in the Journal of Clinical Oncology.

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Antidepressants + Exercise Beneficial in Late-Life Depression

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- For older adults with late-life major depression (LLMD), the combination of antidepressants (AD) and physical exercise (PE) seems beneficial, especially for individuals with specific characteristics, according to research published online Nov. 21 in the Journal of the American Geriatrics Society.

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Many Nursing Home Residents Not Taking β-Blockers After AMI

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- Many nursing home (NH) residents do not initiate beta-blocker use after acute myocardial infarction (AMI), according to a study published online Nov. 15 in the Journal of the American Geriatrics Society.

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High-Dose Vitamin D Cuts Acute Respiratory Infection in Elderly

TUESDAY, Nov. 22, 2016 (HealthDay News) -- For long-term care facility residents, high-dose vitamin D3 supplementation is associated with reduced incidence of acute respiratory infection (ARI) but increased incidence of falls, according to a study published online Nov. 16 in the Journal of the American Geriatrics Society.

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Four ER Visits for Adverse Drug Events Per 1,000 People

TUESDAY, Nov. 22, 2016 (HealthDay News) -- In 2013 to 2014, the estimated prevalence of emergency department visits for adverse drug events was four per 1,000 individuals, according to research published in the Nov. 22 issue of the Journal of the American Medical Association.

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Rising Rx, ER Prices Pushing U.S. Health Care Spending Up

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Privately insured Americans spent nearly 5 percent more on health care last year than in 2014; this increase was significantly more than that seen in previous years and reflects higher costs for prescription drugs, emergency department visits, and hospitalizations, according to a report published Nov. 22 by the Health Care Cost Institute.

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Computer Order Entry System Ups Antimicrobial Policy Compliance

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Use of a computerized physician order entry (CPOE) system can improve compliance with antimicrobial restriction policies, according to a study published online Nov. 16 in the Journal of Pharmacy Practice and Research.

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Beta-Blocker Tx Attenuates Prognostic Value of ppMHR

TUESDAY, Nov. 22, 2016 (HealthDay News) -- The prognostic value of lower heart rate thresholds (defined as the percentage of age-predicted maximal heart rate achieved, or ppMHR) is attenuated for patients on beta-blocker therapy (BBT), according to a study published in the Dec. 1 issue of The American Journal of Cardiology.

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Thromboembolic Events Common With Chemo for Bladder Cancer

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Patients with muscle invasive bladder cancer who undergo neoadjuvant chemotherapy before and after radical cystectomy frequently experience thromboembolic events, according to a study published in the December issue of The Journal of Urology.

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Medication Errors Common in Nursing Home Residents

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Medication errors (MEs) occur frequently among nursing home residents, but they rarely have serious effects, according to a review published online Nov. 21 in the Journal of the American Geriatrics Society.

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Discussing Opioid Risks With Patients Reduces Misuse

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Discussing the risk of long-term opioid use disorder with patients is associated with reduced misuse of opioids, according to research published in the November/December issue of the Annals of Family Medicine.

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Acne Treatment Often Not in Line With Current Guidelines

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Among U.K. general practitioners, acne treatment is often not in accordance with current guidelines, according to a study published in the December issue of the Journal of the American Academy of Dermatology.

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Hemorrhage Risk Up in A-Fib Patients on Dabigatran, Statins

MONDAY, Nov. 21, 2016 (HealthDay News) -- Combining dabigatran with certain statin medications could raise the odds for major hemorrhage in patients with atrial fibrillation, according to a study published online Nov. 21 in CMAJ, the journal of the Canadian Medical Association.

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Retail Clinics Don't Reduce ER Visits for Minor Ailments

MONDAY, Nov. 21, 2016 (HealthDay News) -- Having retail health clinics near hospitals does not reduce emergency department visits for minor health problems, according to a study published online Nov. 10 in the Annals of Emergency Medicine.

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Thiazide-Type Diuretic Treatment Tied to Lower Fracture Risk

MONDAY, Nov. 21, 2016 (HealthDay News) -- Thiazide-type diuretic therapy reduces hip and pelvic fracture risk compared with other antihypertensive medication therapy, according to a study published online Nov. 21 in JAMA Internal Medicine.

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Drug-Resistant Infections Tied to Livestock-Associated Staph

MONDAY, Nov. 21, 2016 (HealthDay News) -- Workers at hog production facilities in the United States are developing skin infections from multidrug-resistant Staphylococcus aureus, according to a study published online Nov. 16 in PLOS ONE.

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Local Anesthetic As Safe As General Anesthetic for TAVR

MONDAY, Nov. 21, 2016 (HealthDay News) -- For patients undergoing transcatheter aortic valve replacement (TAVR), local anesthetic (LA) is as safe as general anesthetic (GA), with shorter procedure time and number of days in the hospital, according to a study published in the Dec. 1 issue of The American Journal of Cardiology.

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Treatment Guidelines Updated for Patients With Rosacea

MONDAY, Nov. 21, 2016 (HealthDay News) -- For patients with rosacea, phenotype-based treatments should be given for presenting signs and symptoms, according to updated treatment guidelines published online Nov. 12 in the British Journal of Dermatology.

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Follow-Up Phone Calls May Boost Glycemic Control in T2DM

FRIDAY, Nov. 18, 2016 (HealthDay News) -- For patients with type 2 diabetes, follow-up phone calls after a monthly clinic visit could lead to clinically significant change in hemoglobin A1C (HbA1c) levels, according to a study published online Nov. 13 in the Journal of Clinical Nursing.

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Metformin Alters Gut Microbiota Composition in Diabetes

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Metformin seems to alter gut microbiota composition, according to a study published online Nov. 14 in Diabetes Care.

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Ustekinumab Shows Promise in Crohn's Disease

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Patients with moderate-to-severe Crohn's disease who haven't responded to other treatments may benefit from the drug ustekinumab (Stelara), according to a study published in the Nov. 17 issue of the New England Journal of Medicine.

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FDA Approves Intrarosa for Postmenopausal Pain During Sex

THURSDAY, Nov. 17, 2016 (HealthDay News) -- Intrarosa (prasterone) has been approved by the U.S. Food and Drug Administration to treat women who have moderate-to-severe pain during sexual intercourse caused by postmenopausal vulvar and vaginal atrophy (VVA).

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Palbociclib Efficacious in Metastatic Breast Cancer

THURSDAY, Nov. 17, 2016 (HealthDay News) -- Palbociclib can help slow the progression of advanced breast cancer, according to a study published in the Nov. 17 issue of the New England Journal of Medicine.

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DECIDE Modalities Beneficial for African-Americans With T2DM

THURSDAY, Nov. 17, 2016 (HealthDay News) -- For African-Americans with type 2 diabetes, the Decision-making Education for Choices In Diabetes Everyday (DECIDE) program is beneficial, according to a study published online Nov. 14 in Diabetes Care.

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IV, Oral Antibiotics Compared for Complicated Pneumonia

THURSDAY, Nov. 17, 2016 (HealthDay News) -- For children with complicated pneumonia, peripherally inserted central venous catheter (PICC) and oral antibiotic administration post-discharge have similar rates of treatment failure, according to a study published online Nov. 17 in Pediatrics.

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Competing Risks Influence Warfarin, Thromboembolism Link

THURSDAY, Nov. 17, 2016 (HealthDay News) -- For patients with nonvalvular atrial fibrillation, warfarin is associated with a reduction in thromboembolism, although the correlation is attenuated after accounting for competing death events, according to a study published online Nov. 12 in the Journal of the American Geriatrics Society.

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Sodium Bicarbonate Prophylaxis Linked to Lower Mortality

THURSDAY, Nov. 17, 2016 (HealthDay News) -- For patients undergoing coronary angiography, sodium bicarbonate prophylaxis for contrast-associated nephropathy (CAN) is associated with reduced long-term mortality, according to research published in the Nov. 15 issue of The American Journal of Cardiology.

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Data From Clinical Registries Can ID Novel Drug Interactions

THURSDAY, Nov. 17, 2016 (HealthDay News) -- Data mining can be used to discover unknown drug-drug interactions in cardiovascular medicine, according to a study published online Nov. 8 in Circulation: Cardiovascular Quality and Outcomes.

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Ledipasvir-Sofosbuvir Safe for Kidney Recipients With HCV

WEDNESDAY, Nov. 16, 2016 (HealthDay News) -- For kidney transplant recipients with hepatitis C virus (HCV) genotype 1 or 4 infection, treatment with ledipasvir-sofosbuvir for 12 or 24 weeks is safe and efficacious, according to a study published online Nov. 15 in the Annals of Internal Medicine.

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Medication Adherence Up in Patient-Centered Medical Homes

WEDNESDAY, Nov. 16, 2016 (HealthDay News) -- Medication adherence is increased with receipt of care in a patient-centered medical home, according to a study published online Nov. 15 in the Annals of Internal Medicine.

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Vitamin D Replacement Improves Chronic Widespread Pain

WEDNESDAY, Nov. 16, 2016 (HealthDay News) -- For patients with nonspecific chronic widespread musculoskeletal pain (CWP) and vitamin D deficiency, treatment with vitamin D replacement results in improvements in symptoms, according to a study published online Nov. 11 in the International Journal of Rheumatic Diseases.

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Rate of ADHD Diagnoses Stabilizing Among Preschoolers

TUESDAY, Nov. 15, 2016 (HealthDay News) -- The rate of diagnoses for attention-deficit/hyperactivity disorder (ADHD) among U.S. preschoolers has leveled off, according to a study published online Nov. 15 in Pediatrics.

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Findings Support Bisphosphonate Use in Men With Osteoporosis

TUESDAY, Nov. 15, 2016 (HealthDay News) -- Bisphosphonates reduce the risk of vertebral, and possibly nonvertebral, fractures for men with osteoporosis, according to a review and meta-analysis published online Nov. 7 in the Journal of the American Geriatrics Society.

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GI Adverse Events Up With GLP-1 Receptor Agonists

TUESDAY, Nov. 15, 2016 (HealthDay News) -- Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are associated with increased risk of gastrointestinal adverse events (AEs), with risk varying based on dose, background medications, and type of GLP-1 RA, according to research published online Nov. 9 in Diabetes, Obesity and Metabolism.

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Only Slightly Worse Disease Course for Bacterial LRI

TUESDAY, Nov. 15, 2016 (HealthDay News) -- In patients with acute cough, those with bacterial lower respiratory tract infection (LRTI) have a slightly worse disease course than those without an identified bacterial cause, according to research published in the November/December in the Annals of Family Medicine.

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USPSTF Advises Statins for Some Adults With No CVD History

MONDAY, Nov. 14, 2016 (HealthDay News) -- The U.S. Preventive Services Task Force (USPSTF) recommends that certain adults aged 40 to 75 years without cardiovascular disease (CVD) history but with one or more cardiovascular risk factors initiate statins. These recommendations are included in the final recommendation statement published in the Nov. 15 issue of the Journal of the American Medical Association, a theme issue on statins.

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Guidelines Updated for Management of PAD

MONDAY, Nov. 14, 2016 (HealthDay News) -- In a Clinical Practice Guideline published online Nov. 13 in Circulation, evidence-based recommendations are presented for the management of peripheral artery disease (PAD), focusing on lifestyle modification as well as medical treatment.

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AHR Ligands May Be Therapeutic in Thyroid Eye Disease

MONDAY, Nov. 14, 2016 (HealthDay News) -- Aryl hydrocarbon receptor (AHR) and AHR ligands prevent formation of transforming growth factor (TGF)-β-dependent myofibroblast formation in thyroid eye disease (TED), according to research published online Nov. 11 in The American Journal of Pathology.

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Implantable Continuous Glucose Monitoring System Safe, Accurate

MONDAY, Nov. 14, 2016 (HealthDay News) -- A new implantable continuous glucose monitoring (CGM) system seems to be safe and accurate for diabetes, according to a study published online Nov. 4 in Diabetes Care.

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Efficacy of Wet Wrap Therapy for Atopic Dermatitis Undetermined

MONDAY, Nov. 14, 2016 (HealthDay News) -- Evidence that wet wrap therapy (WWT) is more effective than topical steroids for the treatment of atopic dermatitis is mixed, according to a review published online Nov. 8 in the British Journal of Dermatology.

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Immune Response May Be Key to Chemopreventive Effect of Aspirin

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Regular aspirin use is associated with a lower risk of colorectal carcinomas with low concentrations of tumor infiltrating lymphocytes (TILs), according to a study published in the November issue of Gastroenterology.

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Two-Drug Combo Promising for HIV Remission

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Animal research with an experimental two-drug therapy could hold clues for creating long-term HIV remission, according to a report published online Nov. 9 in Nature.

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Intravaginal Testosterone Deemed Safe in Early Breast CA

FRIDAY, Nov. 11, 2016 (HealthDay News) -- For postmenopausal (PM) women with early-stage breast cancer (BC) taking aromatase inhibitors (AIs), intravaginal testosterone cream (IVT) is safe for vaginal dryness or decreased libido, according to a study published online Nov. 10 in JAMA Oncology.

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HR Capabilities Positively Linked to Quality of Patient Care

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Human resource (HR) capabilities are positively associated with quality of patient care, with the relationship mediated by proactive work, according to a study published recently in Human Resource Management.

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DNA-Based Zika Vaccine Shows Protection Against Infection

THURSDAY, Nov. 10, 2016 (HealthDay News) -- An experimental Zika vaccine shows promise, according to research published online Nov. 10 in npj Vaccines.

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High-Intensity Statins Tied to Better Survival in CVD Patients

THURSDAY, Nov. 10, 2016 (HealthDay News) -- There is a graded association between intensity of statin therapy and mortality for patients with established atherosclerotic cardiovascular disease, according to research published online Nov. 9 in JAMA Cardiology.

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RA Disease Activity Score Most Influential in Patient Reports

THURSDAY, Nov. 10, 2016 (HealthDay News) -- Higher disease activity score (DAS) is one of the most influential factors for poor patient-reported outcomes (PROs) in rheumatoid arthritis (RA), according to a study published online Nov. 5 in the International Journal of Rheumatic Diseases.

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PPI Use Doesn't Up Recurrence of Bacterial Peritonitis

THURSDAY, Nov. 10, 2016 (HealthDay News) -- For patients with cirrhosis with previous spontaneous bacterial peritonitis (SBP), proton pump inhibitor (PPI) use is not associated with SBP recurrence, according to a study published online Nov. 7 in the Journal of Gastroenterology and Hepatology.

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Faster Delivery for Induction With Misoprostol Plus Cervical Foley

THURSDAY, Nov. 10, 2016 (HealthDay News) -- For women undergoing induction, receipt of misoprostol-cervical Foley is associated with an increased likelihood of delivery before those receiving either method alone, according to a study published in the December issue of Obstetrics & Gynecology.

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Dense-Dose Chemo of Little Benefit in Early Breast Cancer

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- Tailored dose-dense chemotherapy offers little benefit over standard chemotherapy for women with high-risk early breast cancer, according to research published in the Nov. 8 issue of the Journal of the American Medical Association.

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U/S IDs Response to Propranolol in Infantile Hemangioma

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- For patients with infantile hemangiomas, serial ultrasonography can be used to show response to propranolol treatment, according to a study published online Nov. 4 in the International Journal of Dermatology.

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Naproxen Sodium Doesn't Reduce Pain With IUD Insertion

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- For patients undergoing intrauterine device (IUD) insertion, oral naproxen sodium does not reduce pain on insertion, but does reduce pain after insertion, according to a study published in the December issue of Obstetrics & Gynecology.

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Recommendations Developed for Lymphangioleiomyomatosis

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- In a Clinical Practice Guideline published in the American Journal of Respiratory and Critical Care Medicine, evidence-based recommendations are presented for the diagnosis and management of lymphangioleiomyomatosis (LAM).

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Anakinra Cuts Risk of Recurrence in Recurrent Pericarditis

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- Use of anakinra reduces the risk of recurrence of pericarditis among patients with recurrent pericarditis with colchicine resistance and corticosteroid dependence, according to a study published in the Nov. 8 issue of the Journal of the American Medical Association.

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Report of Recurrent Immune Thrombocytopenia After Flu Shot

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- In a report published online Nov. 8 in Pediatrics, authors present the case of recurrent immune thrombocytopenia (ITP) after influenza vaccination.

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School-Required Tdap Vaccination Can Up HPV Immunization

TUESDAY, Nov. 8, 2016 (HealthDay News) -- Schools that require routine vaccines as a condition of attendance have higher rates of vaccination, including higher rates of immunization for the human papillomavirus (HPV), and children at these schools are also more likely to get recommended tetanus, diphtheria, and pertussis (Tdap) and meningitis vaccines, according to research published online Nov. 8 in Pediatrics.

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Probable Interaction ID'd for PrOD, Ribavirin With Warfarin

TUESDAY, Nov. 8, 2016 (HealthDay News) -- There is a probable interaction between paritaprevir/ritonavir/ombitasvir+dasabuvir (PrOD) plus ribavirin with warfarin, according to a case report published online Nov. 3 in the Journal of Clinical Pharmacy and Therapeutics.

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AMA Highlights Role of Patient Shame in Opioid Disorders

TUESDAY, Nov. 8, 2016 (HealthDay News) -- Supported by the American Medical Association (AMA), the Providers' Clinical Support System for Opioid Therapies (PCSS-O) has released a collection of resources from a national training and mentoring project developed by physicians to promote the role of self-education and help curb the opioid epidemic.

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Cumulative Incidence of ESRD Low in Patients With Type 1 DM

TUESDAY, Nov. 8, 2016 (HealthDay News) -- Patients with type 1 diabetes diagnosed at age 15 to 27 years have low cumulative incidence of end-stage renal disease (ESRD) and increased mortality during long-term follow-up, according to a study published online Oct. 21 in Diabetes Care.

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With Education, Discharge Blood Glucose Profile Predicts HbA1c

MONDAY, Nov. 7, 2016 (HealthDay News) -- For patients with type 2 diabetes receiving inpatient diabetes education, blood glucose profile at discharge can predict hemoglobin A1c (HbA1c) level at 12 weeks after discharge, according to a study published online Oct. 27 in the Journal of Diabetes Investigation.

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Memantine + Sertraline Effective for Major Depressive Disorder

MONDAY, Nov. 7, 2016 (HealthDay News) -- The combination of memantine plus sertraline is efficacious for major depressive disorder, according to a study published online Nov. 3 in the Journal of Clinical Pharmacy and Therapeutics.

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Nonadherence in Nearly One-Third of Patients With HTN

MONDAY, Nov. 7, 2016 (HealthDay News) -- More than 30 percent of patients with hypertension are not adherent to antihypertensive drug therapy, according to a study published online Nov. 3 in the Journal of Evaluation in Clinical Practice.

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Recommendations Updated for Meningococcal Vaccine in HIV

MONDAY, Nov. 7, 2016 (HealthDay News) -- In the Nov. 4 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report, new recommendations are presented for meningococcal conjugate vaccination among HIV-infected individuals.

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Part D Has Reduced Out-of-Pocket Rx Drug Costs in Diabetes

FRIDAY, Nov. 4, 2016 (HealthDay News) -- Medicare Part D has effectively reduced the out-of-pocket cost burden of prescription drugs for beneficiaries with diabetes, according to a study published online Nov. 1 in Diabetes Care.

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CDC: 13 Cases of Candida auris Identified in the United States

FRIDAY, Nov. 4, 2016 (HealthDay News) -- Thirteen cases of Candida auris, a globally emerging invasive, multidrug-resistant fungus, have been identified in the United States, according to the U.S. Centers for Disease Control and Prevention.

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Thalidomide May Cause Epidermal Necrolysis in Multiple Myeloma

FRIDAY, Nov. 4, 2016 (HealthDay News) -- In patients with multiple myeloma, thalidomide may cause toxic epidermal necrolysis (TEN), according to a case report published online Nov. 2 in the International Journal of Dermatology.

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Adjuvant Endocrine Tx Adherence Disparity Due to Varying Costs

FRIDAY, Nov. 4, 2016 (HealthDay News) -- For women with hormone receptor-positive breast cancer, adherence to adjuvant endocrine therapy (AET) is mainly due to demographic variables and out-of-pocket medication costs, according to a study published online Oct. 28 in the Journal of Clinical Oncology.

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Standard of Care Underused for Locally Advanced Cervical Cancer

FRIDAY, Nov. 4, 2016 (HealthDay News) -- For patients with locally advanced cervical cancer, standard of care (SOC), which includes pelvic external beam radiation (EBRT) with chemotherapy and interdigitated brachytherapy, is associated with significantly improved overall survival but is notably underused, according to a study published in the November issue of Gynecologic Oncology.

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Low-Carb Diet Cuts Tx Effect of Glucagon in Hypoglycemia

FRIDAY, Nov. 4, 2016 (HealthDay News) -- For patients with type 1 diabetes, a low-carbohydrate diet (LCD) results in lower incremental rises in plasma glucose (PG) after mild hypoglycemia compared with an isocaloric high-carbohydrate diet (HCD), according to a study published online Oct. 21 in Diabetes Care.

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Severe Neurologic Disorder With Administration of BIA 10-2474

THURSDAY, Nov. 3, 2016 (HealthDay News) -- Healthy participants receiving the orally administered reversible fatty acid amide hydrolase inhibitor, BIA 10-2474, can experience a severe neurologic disorder, according to research published in the Nov. 3 issue of the New England Journal of Medicine.

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Myocarditis ID'd With Ipilimumab + Nivolumab in Melanoma

THURSDAY, Nov. 3, 2016 (HealthDay News) -- Patients with melanoma treated with a combination of ipilimumab and nivolumab may be at risk for a potentially fatal T-cell-driven drug reaction, according to a report published in the Nov. 3 issue of the New England Journal of Medicine.

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Ambulatory IV Diuretics Cut Costs in Decompensated Heart Failure

THURSDAY, Nov. 3, 2016 (HealthDay News) -- Ambulatory, high-dose intravenous diuretic therapy seems to be cost saving for decompensated heart failure, according to a study published in the Nov. 1 issue of The American Journal of Cardiology.

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Pharmacogenetic Analyses Can Optimize Clomipramine Dosing

THURSDAY, Nov. 3, 2016 (HealthDay News) -- Pharmacogenetic analysis can help optimize clomipramine doses in patients who do not respond to standard-dose treatment, according to a report published online Oct. 31 in the Journal of Clinical Pharmacy and Therapeutics.

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About 30 Percent Misdiagnosed With Lower Extremity Cellulitis

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- More than 30 percent of patients admitted with a diagnosis of lower extremity cellulitis are misdiagnosed, according to a study published online Nov. 2 in JAMA Dermatology.

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Maternal, Neonatal Adverse Events Up With Antenatal ART

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- For HIV-infected pregnant women, antiretroviral therapy (ART) is associated with significantly lower rates of early HIV transmission, but with a higher risk of adverse maternal and neonatal outcomes, according to a study published in the Nov. 3 issue of the New England Journal of Medicine.

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ASCO Updates Guidelines on Integration of Palliative Care

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- The American Society of Clinical Oncology Clinical Practice Guideline on the integration of palliative care into standard oncology care has been updated. The update was published online Oct. 28 in the Journal of Clinical Oncology.

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Community Pharmacists Play Role in Providing Preventive Care

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- Community pharmacists are well suited to provide clinical preventive services, including education, screenings, and making referrals, according to a report published in the Oct. 27 issue of the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Psych Meds Rx May Cut Violent Reoffending in Ex-Prisoners

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- Released prisoners may be less likely to commit violent crimes if they're prescribed certain kinds of psychiatric medications, according to research published in the Nov. 1 issue of the Journal of the American Medical Association.

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Incidence of Statin-Associated T2DM Relatively Low

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- For patients without diabetes, the incidence of statin-associated type 2 diabetes mellitus (T2DM) is relatively low, according to research published in the Nov. 1 issue of The American Journal of Cardiology.

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Outcomes Similar for Rx Dosing Protocols in Ectopic Pregnancy

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- For ectopic pregnancy, outcomes are similar with a single- and double-dose methotrexate protocol, according to a study published in the November issue of the American Journal of Obstetrics & Gynecology.

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Transient Topical Corticosteroids of Limited Use in Acne

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- Transient addition of topical corticosteroids (TCS) to topical retinoids is not associated with meeting the primary end points of improvement in acne severity and mitigation of medication-induced irritation, according to a study published online Oct. 27 in the British Journal of Dermatology.

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Tdap Vaccine During Pregnancy Seems Safe for Mother, Infant

TUESDAY, Nov. 1, 2016 (HealthDay News) -- The tetanus, diphtheria, and pertussis (Tdap) vaccine does not appear to cause birth defects or any other major health problems for a developing fetus, according to a research letter published in the Nov. 1 issue of the Journal of the American Medical Association.

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Genetic Testing May Help ID VTE Risk in Breast Cancer Patients

TUESDAY, Nov. 1, 2016 (HealthDay News) -- Genetic testing could help identify breast cancer patients at high risk for venous thromboembolism (VTE), according to a study published online Nov. 1 in Clinical Cancer Research.

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Educational Intervention Aids Problematic Hypoglycemia

TUESDAY, Nov. 1, 2016 (HealthDay News) -- A brief, partly web-based educational intervention, HypoAware, is beneficial for reducing severe hypoglycemic episodes and improving hypoglycemia awareness compared with usual care, according to a study published online Oct. 20 in Diabetes Care.

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Medicaid Policies Impact Use of Smoking Cessation Medications

TUESDAY, Nov. 1, 2016 (HealthDay News) -- Medicaid policies, such as those that require patients to obtain counseling in order to receive smoking cessation medications, affect use of these medications, according to a study published in the Oct. 27 issue of the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Oral Probiotics Have No Impact on Vaginal Health in Pregnancy

TUESDAY, Nov. 1, 2016 (HealthDay News) -- For pregnant women, probiotics have no effect on vaginal health, according to a study published in the November issue of the American Journal of Obstetrics & Gynecology.

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Weight Gain Impacts 25(OH)D Response in Pregnancy

TUESDAY, Nov. 1, 2016 (HealthDay News) -- Among pregnant women taking cholecalciferol, factors have been identified that impact serum 25-hydroxyvitamin D (25[OH]D) response, including weight gain and season of delivery, according to research published online Oct. 27 in the Journal of Clinical Endocrinology & Metabolism.

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