November 2016 Briefing - Hematology & Oncology

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Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for November 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Outreach Strategies Can Up HCC Screening in Cirrhosis

WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- Outreach programs can increase hepatocellular carcinoma (HCC) screening rates among patients with documented or suspected cirrhosis, according to a study published online Nov. 5 in Gastroenterology.

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Morbidity, Mortality Up for HCT Cancer Survivors

WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- Hematopoietic cell transplantation (HCT) cancer survivors have increased risk of late morbidity and mortality, according to a study published online Nov. 21 in the Journal of Clinical Oncology.

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Meta-Analysis: Statins Cut Risk of Advanced Colorectal Adenoma

WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- Statins seem not to be associated with the risk of colorectal adenoma, but are associated with reduced risk of advanced adenoma, according to a review and meta-analysis published online Nov. 23 in the Journal of Gastroenterology and Hepatology.

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Incidence of Sebaceous Carcinoma Up From 2000 to 2012

TUESDAY, Nov. 29, 2016 (HealthDay News) -- From 2000 to 2012 there was an increase in the incidence of sebaceous carcinoma (SC), according to a study published in the December issue of the Journal of the American Academy of Dermatology.

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Mindfulness-Based Tx Doesn't Cut Distress in Prostate Cancer

TUESDAY, Nov. 29, 2016 (HealthDay News) -- For men with advanced prostate cancer (PC), mindfulness-based cognitive therapy (MBCT) does not reduce distress more than minimally enhanced usual care, according to a study published online Nov. 21 in the Journal of Clinical Oncology.

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Methylation of Gene Panel May Help Predict Breast CA Survival

TUESDAY, Nov. 29, 2016 (HealthDay News) -- Methylation of a gene panel is a strong predictor of survival outcomes in metastatic breast cancer (MBC), according to a study published online Nov. 21 in the Journal of Clinical Oncology.

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Out-of-Pocket Cancer Costs High for Patients With Medicare Only

MONDAY, Nov. 28, 2016 (HealthDay News) -- Medical bills for older U.S. cancer patients can cost one-quarter of their income or more if they have Medicare without supplemental insurance, according to a study published online Nov. 23 in JAMA Oncology.

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ADT Use Not Linked to Dementia in Prostate Cancer

MONDAY, Nov. 28, 2016 (HealthDay News) -- For men with prostate cancer, use of androgen deprivation therapy (ADT) seems not to be associated with dementia, according to a study published online Nov. 21 in the Journal of Clinical Oncology.

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Review Links PPI Use With Risk of Fundic Gland Polyps

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- Long-term proton pump inhibitor (PPI) use is associated with increased risk of fundic gland polyps (FGPs), and may be associated with gastric cancer, according to a review published in the December issue of Clinical Gastroenterology and Hepatology.

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Only Two Doses of HPV Vaccine Necessary for Younger Teens

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- Two doses of the human papillomavirus (HPV) vaccine, rather than three, can effectively protect younger teens against the virus, according to a study published online Nov. 21 in the Journal of the American Medical Association. The study was one of a number evaluated by the U.S. Centers for Disease Control and Prevention earlier this year, which led to the CDC's revised guidelines in October.

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Palliative Care Positively Affects Symptom Burden, QOL

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- Palliative care interventions are associated with improvements in patient quality of life and symptom burden, but do not affect survival, according to a review published in the Nov. 22/29 issue of the Journal of the American Medical Association.

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Increased Cost of CLL Tx Poses Considerable Financial Burden

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- For patients with chronic lymphocytic leukemia (CLL), survival is projected to increase by 2025, and the corresponding cost of care will increase considerably, according to a study published online Nov. 21 in the Journal of Clinical Oncology.

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Mental Distress Common in Survivors of Teen, Young Adult CA

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- Survivors of adolescent and young adult (AYA) cancer are more likely to have mental distress than individuals without cancer, but most do not talk to mental health professionals, according to a study published online Nov. 17 in Cancer.

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USPSTF Continues to Recommend Against Thyroid Cancer Screening

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Clinicians should not screen for thyroid cancer in patients who have no symptoms of the disease, according to a U.S. Preventive Services Task Force (USPSTF) draft recommendation which reaffirms a recommendation issued 20 years ago.

Evidence Review
Draft Recommendation Statement
Comment on Recommendation

Rising Rx, ER Prices Pushing U.S. Health Care Spending Up

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Privately insured Americans spent nearly 5 percent more on health care last year than in 2014; this increase was significantly more than that seen in previous years and reflects higher costs for prescription drugs, emergency department visits, and hospitalizations, according to a report published Nov. 22 by the Health Care Cost Institute.

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Intermittent Hypoxia Promotes Lung Tumor Cell Aggressiveness

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Circulating exosomes released under intermittent hypoxia (IH) conditions, which characterize obstructive sleep apnea (OSA), promote lung tumor cell aggressiveness, according to a study published in the November issue of CHEST.

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Discussing Opioid Risks With Patients Reduces Misuse

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Discussing the risk of long-term opioid use disorder with patients is associated with reduced misuse of opioids, according to research published in the November/December issue of the Annals of Family Medicine.

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Oct4 Found to Be a Prognostic Marker for Digestive Cancers

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Octamer-binding transcription factor 4 (Oct4) is a predictive marker for patients with digestive system cancers, according to a review and meta-analysis published online Nov. 7 in the Journal of Gastroenterology and Hepatology.

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Thromboembolic Events Common With Chemo for Bladder Cancer

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Patients with muscle invasive bladder cancer who undergo neoadjuvant chemotherapy before and after radical cystectomy frequently experience thromboembolic events, according to a study published in the December issue of The Journal of Urology.

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Small Increase in Hematocrit With Implantable Testosterone

MONDAY, Nov. 21, 2016 (HealthDay News) -- Men treated with implantable testosterone pellets have a statistically significant increase in mean hematocrit, but it is unlikely to be clinically relevant, according to research published in the December issue of The Journal of Urology.

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Updated Index Predicts Survival in NSCLC With Brain Metastases

MONDAY, Nov. 21, 2016 (HealthDay News) -- An updated index incorporating gene and molecular alterations can predict survival in non-small-cell lung cancer (NSCLC) with brain metastases, according to a study published online Nov. 17 in JAMA Oncology.

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HOMA2-IR Tied to Hepatocellular Carcinoma Risk in Hepatitis B

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Insulin resistance assessed by homeostasis model assessment index (HOMA2-IR) correlates with the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection, according to a study published online Nov. 11 in the Journal of Gastroenterology and Hepatology.

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Guidelines Developed for Prostate MRI After Negative Biopsy

THURSDAY, Nov. 17, 2016 (HealthDay News) -- In a consensus statement from the American Urological Association and Society of Abdominal Radiology, published in the December issue of The Journal of Urology, guidelines are presented for prostate magnetic resonance imaging (MRI) in patients with negative biopsy.

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CDC: Heart Disease Still Leading Cause of Death

THURSDAY, Nov. 17, 2016 (HealthDay News) -- Heart disease continues to top the list of likely cause of death among Americans, according to research published in the Nov. 18 issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.

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Palbociclib Efficacious in Metastatic Breast Cancer

THURSDAY, Nov. 17, 2016 (HealthDay News) -- Palbociclib can help slow the progression of advanced breast cancer, according to a study published in the Nov. 17 issue of the New England Journal of Medicine.

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Poor Sensitivity for HPV 16/18 in Minor Abnormal Cytology

THURSDAY, Nov. 17, 2016 (HealthDay News) -- Testing for human papillomavirus (HPV) 16/18 has poor sensitivity for triaging women with minor abnormal cytology, according to a meta-analysis published online Nov. 15 in the Annals of Internal Medicine.

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Shoulder-Related Issues Common After Thyroid Cancer Surgery

WEDNESDAY, Nov. 16, 2016 (HealthDay News) -- Patients with thyroid carcinoma undergoing thyroid surgery often have shoulder-related complaints, according to a study published online Nov. 12 in Head & Neck.

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Guidelines Developed for HER2 Testing in Gastroesophageal CA

TUESDAY, Nov. 15, 2016 (HealthDay News) -- In guidelines published online Nov. 14 in the Journal of Clinical Oncology, recommendations are presented for optimal HER2 testing in patients with advanced gastroesophageal adenocarcinoma (GEA).

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Immune Response May Be Key to Chemopreventive Effect of Aspirin

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Regular aspirin use is associated with a lower risk of colorectal carcinomas with low concentrations of tumor infiltrating lymphocytes (TILs), according to a study published in the November issue of Gastroenterology.

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Endobronchial Ultrasound Can ID Pulmonary Thromboembolism

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Endobronchial ultrasound (EBUS) can identify pulmonary thromboembolism, according to a study published online Nov. 3 in the Journal of Clinical Ultrasound.

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Intravaginal Testosterone Deemed Safe in Early Breast CA

FRIDAY, Nov. 11, 2016 (HealthDay News) -- For postmenopausal (PM) women with early-stage breast cancer (BC) taking aromatase inhibitors (AIs), intravaginal testosterone cream (IVT) is safe for vaginal dryness or decreased libido, according to a study published online Nov. 10 in JAMA Oncology.

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CDC: Tobacco-Linked Cancers Make Up 40 Percent of All Cancers

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Although rates of smoking in the United States have declined to new lows, health officials still estimate that four out of every 10 cancers is linked to the habit.

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HR Capabilities Positively Linked to Quality of Patient Care

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Human resource (HR) capabilities are positively associated with quality of patient care, with the relationship mediated by proactive work, according to a study published recently in Human Resource Management.

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Clinical Features Can Be Used to Tailor Melanoma Screening

THURSDAY, Nov. 10, 2016 (HealthDay News) -- Certain patients at high risk of melanoma may benefit from more tailored skin exams, according to a study published online Nov. 9 in JAMA Dermatology.

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Higher Serum Vitamin D Levels Up Survival in Breast Cancer

THURSDAY, Nov. 10, 2016 (HealthDay News) -- Serum 25-hydroxyvitamin D levels may affect breast cancer patients' chances of survival, according to a study published online Nov. 10 in JAMA Oncology.

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Protein Intake Tied to Modest Survival Advantage in Breast CA

THURSDAY, Nov. 10, 2016 (HealthDay News) -- For women with breast cancer, higher intake of protein is associated with a modest survival advantage, according to a study published online Nov. 7 in the Journal of Clinical Oncology.

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CRC Detected After Colonoscopy Often Located in Proximal Colon

THURSDAY, Nov. 10, 2016 (HealthDay News) -- Colorectal cancer (CRC) detected after colonoscopy examination is more often located in the proximal colon and more likely to have DNA mismatch repair deficiency (dMMR), according to a study published in the November issue of Gastroenterology.

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Dense-Dose Chemo of Little Benefit in Early Breast Cancer

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- Tailored dose-dense chemotherapy offers little benefit over standard chemotherapy for women with high-risk early breast cancer, according to research published in the Nov. 8 issue of the Journal of the American Medical Association.

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Multiple Dysplastic Lesions in Esophagus Up Risk of SCC

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- Patients with multiple areas of dysplastic squamous epithelium have increased risk for metachronous squamous cell carcinomas in the upper aerodigestive tract, according to a study published in the November issue of Gastroenterology.

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Report of Recurrent Immune Thrombocytopenia After Flu Shot

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- In a report published online Nov. 8 in Pediatrics, authors present the case of recurrent immune thrombocytopenia (ITP) after influenza vaccination.

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Long-Term Health Not Improved for Childhood Cancer Survivors

TUESDAY, Nov. 8, 2016 (HealthDay News) -- Despite three decades of advancements in treating children with cancer, patients who survive into adulthood don't report better physical or mental health than their counterparts who were treated years ago, according to research published online Nov. 8 in the Annals of Internal Medicine.

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Age at Cancer Diagnosis Key in Determining Later Cardiac Risk

TUESDAY, Nov. 8, 2016 (HealthDay News) -- The age at which cancer survivors are diagnosed with their disease may help predict their risk of death from cardiac disease, according to research published online Nov. 7 in Circulation.

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AMA Highlights Role of Patient Shame in Opioid Disorders

TUESDAY, Nov. 8, 2016 (HealthDay News) -- Supported by the American Medical Association (AMA), the Providers' Clinical Support System for Opioid Therapies (PCSS-O) has released a collection of resources from a national training and mentoring project developed by physicians to promote the role of self-education and help curb the opioid epidemic.

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Second Opinions Seldom Change Prostate Cancer Decisions

MONDAY, Nov. 7, 2016 (HealthDay News) -- Second opinions have little impact on prostate cancer patients' treatment decisions, according to findings published online Nov. 7 in Cancer.

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Weight Loss May Not Benefit Colon, Liver Cancer

MONDAY, Nov. 7, 2016 (HealthDay News) -- Weight loss following chemically-induced carcinogenesis is not beneficial for colon and liver carcinogenesis in a mouse model that mimics human obesity, according to an experimental study published in the Oct. 1 issue of the American Journal of Physiology-Gastrointestinal and Liver Physiology.

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Five Strategies Can Reduce Risk of Medical Lawsuits

MONDAY, Nov. 7, 2016 (HealthDay News) -- Five strategies can be employed by physicians in order to help reduce the risk of lawsuits, according to an article published in Medical Economics.

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No Recommendation for Inpatient Inherited Thrombophilia Testing

MONDAY, Nov. 7, 2016 (HealthDay News) -- Inpatient assessment for inherited thrombophilia is not recommended, according to a review published in the November issue of the Journal of Hospital Medicine.

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Smoking Ups Cancer Risk by Causing Distinct Cell Mutations

FRIDAY, Nov. 4, 2016 (HealthDay News) -- Tobacco smoking causes mutations that lead to cancer by multiple distinct mechanisms, according to a study published in the Nov. 4 issue of Science.

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Decreased Clot Retraction Rate in Asthma

FRIDAY, Nov. 4, 2016 (HealthDay News) -- Clot retraction rate (CRR) and fibrinolysis rate (FR) are reduced in steroid-naive asthma, according to a study published online Oct. 14 in Allergy.

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Standard of Care Underused for Locally Advanced Cervical Cancer

FRIDAY, Nov. 4, 2016 (HealthDay News) -- For patients with locally advanced cervical cancer, standard of care (SOC), which includes pelvic external beam radiation (EBRT) with chemotherapy and interdigitated brachytherapy, is associated with significantly improved overall survival but is notably underused, according to a study published in the November issue of Gynecologic Oncology.

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Adjuvant Endocrine Tx Adherence Disparity Due to Varying Costs

FRIDAY, Nov. 4, 2016 (HealthDay News) -- For women with hormone receptor-positive breast cancer, adherence to adjuvant endocrine therapy (AET) is mainly due to demographic variables and out-of-pocket medication costs, according to a study published online Oct. 28 in the Journal of Clinical Oncology.

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Thalidomide May Cause Epidermal Necrolysis in Multiple Myeloma

FRIDAY, Nov. 4, 2016 (HealthDay News) -- In patients with multiple myeloma, thalidomide may cause toxic epidermal necrolysis (TEN), according to a case report published online Nov. 2 in the International Journal of Dermatology.

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Robotic Surgery Faster for Laparoscopy in Endometrial CA

THURSDAY, Nov. 3, 2016 (HealthDay News) -- For patients with endometrial cancer, robotic-assisted laparoscopic surgery is faster than traditional surgery, according to a study published in the November issue of the American Journal of Obstetrics & Gynecology.

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Differences in Risk Factor Estimates for Prostate Cancer

THURSDAY, Nov. 3, 2016 (HealthDay News) -- For screened men enrolled in prostate cancer prevention trials, there are considerable differences in risk factor estimates for prostate cancer, according to a study published online Oct. 28 in the Journal of Clinical Oncology.

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Myocarditis ID'd With Ipilimumab + Nivolumab in Melanoma

THURSDAY, Nov. 3, 2016 (HealthDay News) -- Patients with melanoma treated with a combination of ipilimumab and nivolumab may be at risk for a potentially fatal T-cell-driven drug reaction, according to a report published in the Nov. 3 issue of the New England Journal of Medicine.

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ASCO Updates Guidelines on Integration of Palliative Care

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- The American Society of Clinical Oncology Clinical Practice Guideline on the integration of palliative care into standard oncology care has been updated. The update was published online Oct. 28 in the Journal of Clinical Oncology.

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Patient Age Linked to Survival in Papillary Thyroid Cancer

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- For patients with papillary thyroid cancer (PTC), patient age is associated with death in a linear fashion, with no apparent age cut point demarcating survival difference, according to a study published online Oct. 28 in the Journal of Clinical Oncology.

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Genetic Testing May Help ID VTE Risk in Breast Cancer Patients

TUESDAY, Nov. 1, 2016 (HealthDay News) -- Genetic testing could help identify breast cancer patients at high risk for venous thromboembolism (VTE), according to a study published online Nov. 1 in Clinical Cancer Research.

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Use of Term 'Rule Out' May Delay Dermatopathology Diagnosis

TUESDAY, Nov. 1, 2016 (HealthDay News) -- In an non-integrated dermatopathology practice, use of the term "rule out" on the requisition form (RF) may cause diagnostic delays and use of unnecessary pathology services, according to a study published online Oct. 25 in the International Journal of Dermatology.

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Intervention Improves Cognitive Symptoms in Cancer Survivors

TUESDAY, Nov. 1, 2016 (HealthDay News) -- A web-based cognitive rehabilitation program can improve cognitive symptoms in cancer survivors, according to a study published online Oct. 28 in the Journal of Clinical Oncology.

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