November 2016 Briefing - Gastroenterology

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Here are what the editors at HealthDay consider to be the most important developments in Gastroenterology for November 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Preemies Often Receive Gastroesophageal Reflux Meds

WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- Thirty-seven percent of premature infants receive gastroesophageal reflux (GER) medications, with more than three-quarters initiating medication use after discharge from the neonatal intensive care unit (NICU), according to a study published online Nov. 23 in Pediatrics.

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Outreach Strategies Can Up HCC Screening in Cirrhosis

WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- Outreach programs can increase hepatocellular carcinoma (HCC) screening rates among patients with documented or suspected cirrhosis, according to a study published online Nov. 5 in Gastroenterology.

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Meta-Analysis: Statins Cut Risk of Advanced Colorectal Adenoma

WEDNESDAY, Nov. 30, 2016 (HealthDay News) -- Statins seem not to be associated with the risk of colorectal adenoma, but are associated with reduced risk of advanced adenoma, according to a review and meta-analysis published online Nov. 23 in the Journal of Gastroenterology and Hepatology.

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Optimal MELD Threshold for HCV Tx Pre-Liver Transplant 23 to 27

TUESDAY, Nov. 29, 2016 (HealthDay News) -- For hepatitis C virus (HCV) patients with decompensated cirrhosis who are eligible for liver transplant (LT), the optimal model for end-stage liver disease (MELD) threshold below which they should receive HCV treatment is 23 to 27, according to a study published online Nov. 5 in Hepatology.

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In Acetaminophen-Induced Acute Liver Failure, FABP1 IDs Mortality

MONDAY, Nov. 28, 2016 (HealthDay News) -- Serum liver-type fatty acid binding protein (FABP1) early (day one) or late (day three to five) levels are associated with mortality in patients with acetaminophen (APAP)-induced acute liver failure (ALF), according to a study published online Nov. 18 in Hepatology.

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Initial Hospital Contact for Alcohol Issues Predicts Cirrhosis

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- An initial hospital contact for alcohol problems is a significant predictor of alcoholic liver cirrhosis, particularly for patients 40 to 59 years and those diagnosed with harmful use or dependence, according to a study published online Nov. 16 in Hepatology.

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Review Links PPI Use With Risk of Fundic Gland Polyps

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- Long-term proton pump inhibitor (PPI) use is associated with increased risk of fundic gland polyps (FGPs), and may be associated with gastric cancer, according to a review published in the December issue of Clinical Gastroenterology and Hepatology.

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Review Suggests Yoga Beneficial in Irritable Bowel Syndrome

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- Yoga is associated with decreased bowel symptoms, disease severity, and anxiety in patients with irritable bowel syndrome (IBS), according to a review published in the December issue of Clinical Gastroenterology and Hepatology.

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Rising Rx, ER Prices Pushing U.S. Health Care Spending Up

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Privately insured Americans spent nearly 5 percent more on health care last year than in 2014; this increase was significantly more than that seen in previous years and reflects higher costs for prescription drugs, emergency department visits, and hospitalizations, according to a report published Nov. 22 by the Health Care Cost Institute.

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Oct4 Found to Be a Prognostic Marker for Digestive Cancers

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Octamer-binding transcription factor 4 (Oct4) is a predictive marker for patients with digestive system cancers, according to a review and meta-analysis published online Nov. 7 in the Journal of Gastroenterology and Hepatology.

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HOMA2-IR Tied to Hepatocellular Carcinoma Risk in Hepatitis B

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Insulin resistance assessed by homeostasis model assessment index (HOMA2-IR) correlates with the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection, according to a study published online Nov. 11 in the Journal of Gastroenterology and Hepatology.

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Metformin Alters Gut Microbiota Composition in Diabetes

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Metformin seems to alter gut microbiota composition, according to a study published online Nov. 14 in Diabetes Care.

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Ustekinumab Shows Promise in Crohn's Disease

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Patients with moderate-to-severe Crohn's disease who haven't responded to other treatments may benefit from the drug ustekinumab (Stelara), according to a study published in the Nov. 17 issue of the New England Journal of Medicine.

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Smart Skin Patch Can Monitor Body Function Acoustically

THURSDAY, Nov. 17, 2016 (HealthDay News) -- A new type of acoustic sensor that resembles a small Band-Aid on the skin can monitor heartbeat and other health measures, according to a study published online Nov. 16 in Science Advances.

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Guidelines Developed for HER2 Testing in Gastroesophageal CA

TUESDAY, Nov. 15, 2016 (HealthDay News) -- In guidelines published online Nov. 14 in the Journal of Clinical Oncology, recommendations are presented for optimal HER2 testing in patients with advanced gastroesophageal adenocarcinoma (GEA).

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GI Adverse Events Up With GLP-1 Receptor Agonists

TUESDAY, Nov. 15, 2016 (HealthDay News) -- Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are associated with increased risk of gastrointestinal adverse events (AEs), with risk varying based on dose, background medications, and type of GLP-1 RA, according to research published online Nov. 9 in Diabetes, Obesity and Metabolism.

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Immune Response May Be Key to Chemopreventive Effect of Aspirin

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Regular aspirin use is associated with a lower risk of colorectal carcinomas with low concentrations of tumor infiltrating lymphocytes (TILs), according to a study published in the November issue of Gastroenterology.

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Constipation May Be Associated With Poor Kidney Health

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Some kidney disease might be prevented or treated by managing constipation, according to a study published online Nov. 10 in the Journal of the American Society of Nephrology.

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HR Capabilities Positively Linked to Quality of Patient Care

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Human resource (HR) capabilities are positively associated with quality of patient care, with the relationship mediated by proactive work, according to a study published recently in Human Resource Management.

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PPI Use Doesn't Up Recurrence of Bacterial Peritonitis

THURSDAY, Nov. 10, 2016 (HealthDay News) -- For patients with cirrhosis with previous spontaneous bacterial peritonitis (SBP), proton pump inhibitor (PPI) use is not associated with SBP recurrence, according to a study published online Nov. 7 in the Journal of Gastroenterology and Hepatology.

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CRC Detected After Colonoscopy Often Located in Proximal Colon

THURSDAY, Nov. 10, 2016 (HealthDay News) -- Colorectal cancer (CRC) detected after colonoscopy examination is more often located in the proximal colon and more likely to have DNA mismatch repair deficiency (dMMR), according to a study published in the November issue of Gastroenterology.

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Multiple Dysplastic Lesions in Esophagus Up Risk of SCC

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- Patients with multiple areas of dysplastic squamous epithelium have increased risk for metachronous squamous cell carcinomas in the upper aerodigestive tract, according to a study published in the November issue of Gastroenterology.

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Probable Interaction ID'd for PrOD, Ribavirin With Warfarin

TUESDAY, Nov. 8, 2016 (HealthDay News) -- There is a probable interaction between paritaprevir/ritonavir/ombitasvir+dasabuvir (PrOD) plus ribavirin with warfarin, according to a case report published online Nov. 3 in the Journal of Clinical Pharmacy and Therapeutics.

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Five Strategies Can Reduce Risk of Medical Lawsuits

MONDAY, Nov. 7, 2016 (HealthDay News) -- Five strategies can be employed by physicians in order to help reduce the risk of lawsuits, according to an article published in Medical Economics.

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Weight Loss May Not Benefit Colon, Liver Cancer

MONDAY, Nov. 7, 2016 (HealthDay News) -- Weight loss following chemically-induced carcinogenesis is not beneficial for colon and liver carcinogenesis in a mouse model that mimics human obesity, according to an experimental study published in the Oct. 1 issue of the American Journal of Physiology-Gastrointestinal and Liver Physiology.

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Smoking Ups Cancer Risk by Causing Distinct Cell Mutations

FRIDAY, Nov. 4, 2016 (HealthDay News) -- Tobacco smoking causes mutations that lead to cancer by multiple distinct mechanisms, according to a study published in the Nov. 4 issue of Science.

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Half of Americans Have at Least One Chronic Health Condition

THURSDAY, Nov. 3, 2016 (HealthDay News) -- More than half of Americans have at least one chronic disease, mental illness, or problem with drugs or alcohol, according to a study published online recently in Psychology, Health & Medicine.

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Acute Hepatitis Described With Excessive Energy Drink Intake

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- A case of acute hepatitis tied to excessive energy drink consumption is detailed in a report published online Nov. 1 in BMJ Case Reports.

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Review: Colon Capsule Endoscopy Accurate in Polyp Detection

TUESDAY, Nov. 1, 2016 (HealthDay News) -- Colon capsule endoscopy (CCE), especially second-generation CCE (CCE-2), has high sensitivity and specificity for detecting colorectal polyps, according to a review published in the November issue of Clinical Gastroenterology and Hepatology.

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