November 2016 Briefing - Diabetes & Endocrinology

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Here are what the editors at HealthDay consider to be the most important developments in Diabetes & Endocrinology for November 2016. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

As Prices Soar, ADA Calls for Access to Affordable Insulin

TUESDAY, Nov. 29, 2016 (HealthDay News) -- In early November, Sen. Bernie Sanders, the Vermont Democrat, pointed out that certain insulins had risen from $21 a vial in 1996 to $255 a vial in 2016.

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Three Factors Weigh Heavy in Risk of Heart Failure

TUESDAY, Nov. 29, 2016 (HealthDay News) -- Middle-aged adults who've avoided obesity, hypertension, and diabetes are far less likely than others to develop heart failure in their later years, according to research published in the Dec. 1 issue of JACC: Heart Failure.

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Renal Outcomes Up With BP <120/70 in T1DM

TUESDAY, Nov. 29, 2016 (HealthDay News) -- For patients with type 1 diabetes, blood pressure (BP) of <120/70 mm Hg is associated with a substantially reduced risk of adverse renal outcomes, according to a study published online Nov. 21 in Diabetes Care.

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Liraglutide Doesn't Affect Gastric Emptying in Type 1 Diabetes

MONDAY, Nov. 28, 2016 (HealthDay News) -- For individuals with type 1 diabetes mellitus (T1DM), liraglutide therapy does not affect the rate of gastric emptying (GE) during hypoglycemia, according to a study published online Nov. 21 in Diabetes, Obesity and Metabolism.

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Long-Term Improvement in Insulin Sensitivity After RYGB

WEDNESDAY, Nov. 23, 2016 (HealthDay News) -- Despite weight regain, Roux-en-Y gastric bypass (RYGB) is associated with long-term improvement in insulin sensitivity and adipose phenotypes, according to a study published online Nov. 16 in Diabetes Care.

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Four ER Visits for Adverse Drug Events Per 1,000 People

TUESDAY, Nov. 22, 2016 (HealthDay News) -- In 2013 to 2014, the estimated prevalence of emergency department visits for adverse drug events was four per 1,000 individuals, according to research published in the Nov. 22 issue of the Journal of the American Medical Association.

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USPSTF Continues to Recommend Against Thyroid Cancer Screening

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Clinicians should not screen for thyroid cancer in patients who have no symptoms of the disease, according to a U.S. Preventive Services Task Force (USPSTF) draft recommendation which reaffirms a recommendation issued 20 years ago.

Evidence Review
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Rising Rx, ER Prices Pushing U.S. Health Care Spending Up

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Privately insured Americans spent nearly 5 percent more on health care last year than in 2014; this increase was significantly more than that seen in previous years and reflects higher costs for prescription drugs, emergency department visits, and hospitalizations, according to a report published Nov. 22 by the Health Care Cost Institute.

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Arsenic Metabolism Linked to Development of Type 1 Diabetes

TUESDAY, Nov. 22, 2016 (HealthDay News) -- Arsenic metabolism seems to be associated with type 1 diabetes in young people, with a potential interaction by folate levels, according to a study published online Nov. 11 in Diabetes Care.

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Thiazide-Type Diuretic Treatment Tied to Lower Fracture Risk

MONDAY, Nov. 21, 2016 (HealthDay News) -- Thiazide-type diuretic therapy reduces hip and pelvic fracture risk compared with other antihypertensive medication therapy, according to a study published online Nov. 21 in JAMA Internal Medicine.

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Metabolic Benefit Same With Similar Weight Loss After Surgery

MONDAY, Nov. 21, 2016 (HealthDay News) -- Early metabolic differences following laparoscopic adjustable gastric banding (LAGB) and Roux-en-Y gastric bypass (RYGB) in obese individuals with type 2 diabetes mellitus (T2DM) disappear when weight loss reaches 20 percent, regardless of surgery type, according to a study published online Nov. 8 in Diabetes Care.

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Calculator May Help Predict Individual Chances of IVF Success

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Free online calculators can predict how likely a woman is to have a baby after a series of in vitro fertilization (IVF) treatment cycles, according to a study published online Nov. 16 in The BMJ.

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Metformin Alters Gut Microbiota Composition in Diabetes

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Metformin seems to alter gut microbiota composition, according to a study published online Nov. 14 in Diabetes Care.

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Follow-Up Phone Calls May Boost Glycemic Control in T2DM

FRIDAY, Nov. 18, 2016 (HealthDay News) -- For patients with type 2 diabetes, follow-up phone calls after a monthly clinic visit could lead to clinically significant change in hemoglobin A1C (HbA1c) levels, according to a study published online Nov. 13 in the Journal of Clinical Nursing.

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Mortality Risk Up for Hospital Patients With Hypoglycemia

FRIDAY, Nov. 18, 2016 (HealthDay News) -- Hospital patients with hypoglycemia may be at increased mortality risk, according to research published online Nov. 17 in the Journal of Clinical Endocrinology & Metabolism.

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DECIDE Modalities Beneficial for African-Americans With T2DM

THURSDAY, Nov. 17, 2016 (HealthDay News) -- For African-Americans with type 2 diabetes, the Decision-making Education for Choices In Diabetes Everyday (DECIDE) program is beneficial, according to a study published online Nov. 14 in Diabetes Care.

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Medication Adherence Up in Patient-Centered Medical Homes

WEDNESDAY, Nov. 16, 2016 (HealthDay News) -- Medication adherence is increased with receipt of care in a patient-centered medical home, according to a study published online Nov. 15 in the Annals of Internal Medicine.

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GI Adverse Events Up With GLP-1 Receptor Agonists

TUESDAY, Nov. 15, 2016 (HealthDay News) -- Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are associated with increased risk of gastrointestinal adverse events (AEs), with risk varying based on dose, background medications, and type of GLP-1 RA, according to research published online Nov. 9 in Diabetes, Obesity and Metabolism.

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CHD Rates Down 20 Percent Since 1980s in the United States

MONDAY, Nov. 14, 2016 (HealthDay News) -- Cases of coronary heart disease (CHD) have dropped 20 percent in the United States over the last four decades, according to a research letter published in the Nov. 15 issue of the Journal of the American Medical Association, a theme issue on statins.

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Implantable Continuous Glucose Monitoring System Safe, Accurate

MONDAY, Nov. 14, 2016 (HealthDay News) -- A new implantable continuous glucose monitoring (CGM) system seems to be safe and accurate for diabetes, according to a study published online Nov. 4 in Diabetes Care.

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AHR Ligands May Be Therapeutic in Thyroid Eye Disease

MONDAY, Nov. 14, 2016 (HealthDay News) -- Aryl hydrocarbon receptor (AHR) and AHR ligands prevent formation of transforming growth factor (TGF)-β-dependent myofibroblast formation in thyroid eye disease (TED), according to research published online Nov. 11 in The American Journal of Pathology.

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Higher Iron Levels Linked to Increased Risk of Gestational DM

FRIDAY, Nov. 11, 2016 (HealthDay News) -- High levels of iron are associated with an increased risk of gestational diabetes, according to research published online Nov. 10 in Diabetologia.

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CDC: Tobacco-Linked Cancers Make Up 40 Percent of All Cancers

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Although rates of smoking in the United States have declined to new lows, health officials still estimate that four out of every 10 cancers is linked to the habit.

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Women With GDM Have Elevated Risk of Future Cardiac Events

FRIDAY, Nov. 11, 2016 (HealthDay News) -- The risk of cardiovascular outcomes is elevated for women with gestational diabetes mellitus (GDM), even in the absence of subsequent type 2 diabetes mellitus (T2DM), according to a study published online Nov. 7 in Diabetes Care.

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Intravaginal Testosterone Deemed Safe in Early Breast CA

FRIDAY, Nov. 11, 2016 (HealthDay News) -- For postmenopausal (PM) women with early-stage breast cancer (BC) taking aromatase inhibitors (AIs), intravaginal testosterone cream (IVT) is safe for vaginal dryness or decreased libido, according to a study published online Nov. 10 in JAMA Oncology.

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HR Capabilities Positively Linked to Quality of Patient Care

FRIDAY, Nov. 11, 2016 (HealthDay News) -- Human resource (HR) capabilities are positively associated with quality of patient care, with the relationship mediated by proactive work, according to a study published recently in Human Resource Management.

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Higher Serum Vitamin D Levels Up Survival in Breast Cancer

THURSDAY, Nov. 10, 2016 (HealthDay News) -- Serum 25-hydroxyvitamin D levels may affect breast cancer patients' chances of survival, according to a study published online Nov. 10 in JAMA Oncology.

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Reduced CD34+ Stem Cells Predicts CV Outcome in T2DM

THURSDAY, Nov. 10, 2016 (HealthDay News) -- Reduced baseline levels of circulating CD34+ stem cells predict adverse cardiovascular outcomes for patients with type 2 diabetes, according to a study published online Nov. 4 in Diabetes Care.

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Prediabetes Screening Guidelines Not Always Followed by PCPs

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- Only about half of U.S. family doctors follow guidelines on screening patients for prediabetes, according to a study published in the November-December issue of the Journal of the American Board of Family Medicine.

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Macrophage COX-2 Prevents Diabetic Nephropathy Progression

WEDNESDAY, Nov. 9, 2016 (HealthDay News) -- Macrophage cyclooxygenase-2 (COX-2) deletion is associated with progression of diabetic nephropathy (DN), according to an experimental study published online Nov. 4 issue of Diabetes.

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Cumulative Incidence of ESRD Low in Patients With Type 1 DM

TUESDAY, Nov. 8, 2016 (HealthDay News) -- Patients with type 1 diabetes diagnosed at age 15 to 27 years have low cumulative incidence of end-stage renal disease (ESRD) and increased mortality during long-term follow-up, according to a study published online Oct. 21 in Diabetes Care.

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BACH2 Identified As Risk Locus for Addison's Disease

TUESDAY, Nov. 8, 2016 (HealthDay News) -- BACH2 is a major risk locus for Addison's disease, according to a study published online Nov. 2 in the Journal of Internal Medicine.

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With Education, Discharge Blood Glucose Profile Predicts HbA1c

MONDAY, Nov. 7, 2016 (HealthDay News) -- For patients with type 2 diabetes receiving inpatient diabetes education, blood glucose profile at discharge can predict hemoglobin A1c (HbA1c) level at 12 weeks after discharge, according to a study published online Oct. 27 in the Journal of Diabetes Investigation.

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Five Strategies Can Reduce Risk of Medical Lawsuits

MONDAY, Nov. 7, 2016 (HealthDay News) -- Five strategies can be employed by physicians in order to help reduce the risk of lawsuits, according to an article published in Medical Economics.

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PCSK9, LDL-C Link Only Seen for Patients With Highest HbA1c

MONDAY, Nov. 7, 2016 (HealthDay News) -- For patients with type 1 diabetes (T1D), the correlation between pro-protein convertase subtilisin/kexin type 9 (PCSK9) and low-density lipoprotein cholesterol (LDL-C) is only seen in the highest tertile for hemoglobin A1c (HbA1c), according to a study published online Nov. 2 in Diabetes, Obesity and Metabolism.

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Part D Has Reduced Out-of-Pocket Rx Drug Costs in Diabetes

FRIDAY, Nov. 4, 2016 (HealthDay News) -- Medicare Part D has effectively reduced the out-of-pocket cost burden of prescription drugs for beneficiaries with diabetes, according to a study published online Nov. 1 in Diabetes Care.

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Deferred Revascularization Tied to Poor Outcomes in Diabetes

FRIDAY, Nov. 4, 2016 (HealthDay News) -- For patients with diabetes mellitus (DM), deferred revascularization is associated with poor medium-term outcomes, according to a study published in the Nov. 1 issue of The American Journal of Cardiology.

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Blocking Ceramide Production Might Prevent Type 2 Diabetes

FRIDAY, Nov. 4, 2016 (HealthDay News) -- High ceramide levels may increase diabetes risk, while low levels could protect against the disease, according to findings from an experimental study published online Nov. 3 in Cell Metabolism.

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Low-Carb Diet Cuts Tx Effect of Glucagon in Hypoglycemia

FRIDAY, Nov. 4, 2016 (HealthDay News) -- For patients with type 1 diabetes, a low-carbohydrate diet (LCD) results in lower incremental rises in plasma glucose (PG) after mild hypoglycemia compared with an isocaloric high-carbohydrate diet (HCD), according to a study published online Oct. 21 in Diabetes Care.

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Half of Americans Have at Least One Chronic Health Condition

THURSDAY, Nov. 3, 2016 (HealthDay News) -- More than half of Americans have at least one chronic disease, mental illness, or problem with drugs or alcohol, according to a study published online recently in Psychology, Health & Medicine.

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Lower Anti-Müllerian Hormone Values for Endometriomas

THURSDAY, Nov. 3, 2016 (HealthDay News) -- Women with endometriomas have significantly lower anti-Müllerian hormone values, and surgical excision of endometriomas appears to have temporary detrimental effects on ovarian reserve, according to a study published in the November issue of the American Journal of Obstetrics & Gynecology.

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Bilateral Renal Denervation Normalizes Insulin Sensitivity

THURSDAY, Nov. 3, 2016 (HealthDay News) -- In obese canines, bilateral renal denervation (RDN) normalizes hepatic insulin sensitivity (SI) by reducing hepatic gluconeogenic genes, according to a study published recently in Diabetes.

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Incidence of Statin-Associated T2DM Relatively Low

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- For patients without diabetes, the incidence of statin-associated type 2 diabetes mellitus (T2DM) is relatively low, according to research published in the Nov. 1 issue of The American Journal of Cardiology.

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Impact of HbA1c, BMI Changes on Lipids Varies As Children Age

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- As children age, the impact of changes in hemoglobin A1c (HbA1c) and body mass index (BMI) on low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol levels increases, according to a study published online Oct. 20 in Diabetes Care.

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Patient Age Linked to Survival in Papillary Thyroid Cancer

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- For patients with papillary thyroid cancer (PTC), patient age is associated with death in a linear fashion, with no apparent age cut point demarcating survival difference, according to a study published online Oct. 28 in the Journal of Clinical Oncology.

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Community Pharmacists Play Role in Providing Preventive Care

WEDNESDAY, Nov. 2, 2016 (HealthDay News) -- Community pharmacists are well suited to provide clinical preventive services, including education, screenings, and making referrals, according to a report published in the Oct. 27 issue of the U.S. Centers for Disease Control and Prevention's Preventing Chronic Disease.

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Educational Intervention Aids Problematic Hypoglycemia

TUESDAY, Nov. 1, 2016 (HealthDay News) -- A brief, partly web-based educational intervention, HypoAware, is beneficial for reducing severe hypoglycemic episodes and improving hypoglycemia awareness compared with usual care, according to a study published online Oct. 20 in Diabetes Care.

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Reduction of Chemical Exposure Cuts Diabetes in Elderly

TUESDAY, Nov. 1, 2016 (HealthDay News) -- For elderly adults, reduction of chemical exposures is associated with reduced burden and costs of diabetes, according to a study published online Oct. 27 in the Journal of Epidemiology & Community Health.

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Weight Gain Impacts 25(OH)D Response in Pregnancy

TUESDAY, Nov. 1, 2016 (HealthDay News) -- Among pregnant women taking cholecalciferol, factors have been identified that impact serum 25-hydroxyvitamin D (25[OH]D) response, including weight gain and season of delivery, according to research published online Oct. 27 in the Journal of Clinical Endocrinology & Metabolism.

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