Novel Prediagnostic Biomarker ID'd for Non-Small-Cell Lung CA

This article originally appeared here.
Share this content:
Novel Prediagnostic Biomarker ID'd for Non-Small-Cell Lung CA
Novel Prediagnostic Biomarker ID'd for Non-Small-Cell Lung CA

FRIDAY, Sept. 18, 2015 (HealthDay News) -- Diacetylspermine is a novel prediagnostic serum biomarker for non-small-cell lung cancer (NSCLC), according to a study published online Aug. 17 in the Journal of Clinical Oncology.

William R. Wikoff, Ph.D., from the University of California in Davis, and colleagues used an untargeted metabolomics approach to identify biomarker candidates using prediagnostic serum samples from the Beta-Carotene and Retinol Efficacy Trial (CARET) study. A liquid chromatography/mass spectrometry hydrophilic interaction method designed to profile a wide range metabolites was applied to CARET samples from 100 patients who subsequently developed NSCLC and 199 matched controls. Based on the results from the discovery set, a metabolite identified as N1,N12-diacetylspermine (DAS) and the previously established protein biomarker, pro-surfactant protein B (pro-SFTPB), were validated in a set of sera from 108 patients with NSCLC and 216 matched controls.

The researchers found that in the discovery set, serum DAS was elevated 1.9-fold, demonstrating significant specificity and sensitivity for samples collected up to six months before NSCLC diagnosis. In both the discovery and validation sets, DAS significantly complemented performance of pro-SFTPB, with a combined area under the curve in the validation set of 0.808 (P < 0.001 versus pro-SFTPB).

"DAS is a novel serum metabolite with significant performance in prediagnostic NSCLC and has additive performance with pro-SFTPB," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Dermatography Helps Lessen Appearance of Surgical Scars

Dermatography Helps Lessen Appearance of Surgical Scars

Pigments can restore more natural skin appearance that patients are happy with

Drug-Resistant Bacteria Live in America's Water Systems

Drug-Resistant Bacteria Live in America's Water Systems

Bacteria found in plumbing may sicken thousands each year

Deep Brain Stimulation May Improve TBI Symptoms

Deep Brain Stimulation May Improve TBI Symptoms

Deep brain stimulation appears to boost function and quality of life

is free, fast, and customized just for you!

Already a member?

Sign In Now »