Novel Abx Appears Promising in Fight Against Resistance

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Novel Abx Appears Promising in Fight Against Resistance
Novel Abx Appears Promising in Fight Against Resistance

THURSDAY, Jan. 8, 2015 (HealthDay News) -- The new antibiotic, teixobactin, has proven effective against a number of bacterial infections that have developed resistance to existing antibiotic drugs, researchers report online Jan. 7 in Nature.

Researchers have used teixobactin to cure lab mice of methicillin-resistant Staphylococcus aureus. The new antibiotic also worked against Streptococcus pneumoniae. Cell culture tests also showed that the new drug effectively eliminated drug-resistant strains of Mycobacterium tuberculosis, Bacillus anthracis, and Clostridium difficile.

Teixobactin kills pathogens by causing their cell walls to break down, similar to vancomycin, the researchers said. It also appears to attack many other growth processes at the same time, giving the researchers hope that bacteria will be unable to quickly develop resistance to the antibiotic.

"My estimate is that we will probably be in clinical trials three years from now," senior author Kim Lewis, Ph.D., director of the Antimicrobial Discovery Center at Northeastern University in Boston, told HealthDay. Lewis said researchers are working to refine the new antibiotic and make it more effective for use in humans.

Several authors are employed by NovoBiotic Pharmaceuticals, which is currently developing teixobactin.

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