Nonalbuminuric CKD Ups Cardiovascular Morbidity in T1DM

This article originally appeared here.
Share this content:
Nonalbuminuric CKD Ups Cardiovascular Morbidity in T1DM
Nonalbuminuric CKD Ups Cardiovascular Morbidity in T1DM

MONDAY, Aug. 31, 2015 (HealthDay News) -- Nonalbuminuric chronic kidney disease is associated with increased risk of cardiovascular disease and all-cause mortality, but not renal outcomes, in patients with type 1 diabetes, according to a study published online Aug. 26 in Diabetes Care.

Lena M. Thorn, M.D., from the Folkhälsan Institute of Genetics in Helsinki, and colleagues conducted an observational follow-up of 3,809 patients with type 1 diabetes from the Finnish Diabetic Nephropathy Study. The authors examined the prevalence of nonalbuminuric chronic kidney disease and its impact on cardiovascular and renal outcomes and mortality.

The researchers found that 2.0 percent of patients had nonalbuminuric chronic kidney disease at baseline. This correlated with older age, female sex, retinal laser treatment history, cardiovascular events, and number of antihypertensive drugs in use; there was no correlation with blood pressure levels or specific antihypertensive agents. Nonalbuminuric chronic kidney disease was not associated with increased risk of albuminuria (hazard ratio [HR], 2.0; 95 percent confidence interval [CI], 0.9 to 4.4) or end-stage renal disease (HR, 6.4; 95 percent CI, 0.8 to 53.0), but did correlate with increased risk of cardiovascular events (HR, 2.0; 95 percent CI, 1.4 to 3.5) and all-cause mortality (HR, 2.4; 95 percent CI, 1.4 to 3.9).

"Nonalbuminuric chronic kidney disease is not a frequent finding in patients with type 1 diabetes, but when present, it is associated with an increased risk of cardiovascular morbidity and all-cause mortality but not with renal outcomes," the authors write.

Several authors disclosed financial ties to pharmaceutical companies, including Novo Nordisk, which partially funded the study.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease


More in Home

Both Statin, Non-Statin Therapies Effective for Lowering LDL

Both Statin, Non-Statin Therapies Effective for Lowering LDL

Dietary changes, other meds, and even surgery can lower cardiovascular risk similarly to statins

Negative Effects Seen With Video Gaming 9 Hours/Week

Negative Effects Seen With Video Gaming 9+ Hours/Week

Benefits seen with one hour a week, but behavioral problems appear to rise at nine hours a week

Improved Adult Lung Function Linked to Childhood Farm Life

Improved Adult Lung Function Linked to Childhood Farm ...

First study to report beneficial effects of growing up on a farm on adult FEV1

is free, fast, and customized just for you!

Already a member?

Sign In Now »