Non-Specialists Can Expand Hepatitis C Treatment Access

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Non-Specialists Can Expand Hepatitis C Treatment Access
Non-Specialists Can Expand Hepatitis C Treatment Access

TUESDAY, Aug. 8, 2017 (HealthDay News) -- Non-specialists, including primary care providers (PCPs) and nurse practitioners (NPs), safely and effectively administer direct-acting antiviral therapy for hepatitis C virus (HCV) to patients seen in federally qualified health centers (FQHCs), according to a study published online Aug. 8 in the Annals of Internal Medicine.

Sarah Kattakuzhy, M.D., from the University of Maryland in Baltimore, and colleagues assigned 600 patients (seen at 13 urban FQHCs) in a nonrandomized but specified manner to receive treatment from one of five NPs, five PCPs, or six specialists. All providers underwent an identical three-hour training session. Patients received treatment with ledipasvir-sofosbuvir according to U.S. Food and Drug Administration labeling requirements.

The researchers found that 86 percent of patients achieved a sustained virologic response (SVR), with no major safety concerns. Response rates were similar across the provider types: NPs, 89.3 percent; PCPs, 86.9 percent; and specialists, 83.8 percent. Non-SVR was primarily caused by patient loss to follow-up.

"NPs and PCPs with compact didactic training could substantially expand the availability of community-based providers to escalate HCV therapy, bridging existing gaps in the continuum of care for patients with HCV infection," the authors write.

Several authors disclosed financial ties to biopharmaceutical companies, including Gilead, which manufactures ledipasvir-sofosbuvir and provided funding for the study.

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