Non-Shivering Thermogenesis Can Activate Metabolic Pathways

This article originally appeared here.
Share this content:
Non-Shivering Thermogenesis Can Activate Metabolic Pathways
Non-Shivering Thermogenesis Can Activate Metabolic Pathways

MONDAY, June 5, 2017 (HealthDay News) -- Non-shivering thermogenesis can transform storage adipose tissues into metabolically active tissue, according to research published online May 25 in Obesity Reviews.

Biff F. Palmer, M.D., from the University of Texas Southwestern Medical Center in Dallas, and Deborah J. Clegg, Ph.D., from Cedars-Sinai Medical Center in Los Angeles, address mechanisms by which non-shivering thermogenesis may offer insight into metabolic pathways that can become targets to facilitate sustainable weight loss.

The researchers note that non-shivering thermogenesis results in activation and expansion of brown and beige adipose tissues; in addition, it activates pathways in skeletal muscle that increase metabolic flux and the activity of muscle fibers via futile calcium cycling across the endoplasmic reticulum. All of these facilitate an increase in metabolism.

"We conclude by emphasizing that non-shivering thermogenesis activates metabolic pathways which could be druggable targets, to facilitate sustainable weight loss," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »