No Response to First Antifungals Tied to Worse Keratitis Outcomes

This article originally appeared here.
Share this content:
No Response to First Antifungals Tied to Worse Keratitis Outcomes
No Response to First Antifungals Tied to Worse Keratitis Outcomes

MONDAY, July 11, 2016 (HealthDay News) -- Fungal keratitis patients pretreated with antifungal medication appear to have worse outcomes, according to a study published online June 21 in Clinical & Experimental Ophthalmology.

Catherine Q. Sun, M.D., from the University of California, San Francisco, and colleagues conducted a randomized , double-blind trial to determine the optimal treatment for filamentous fungal keratitis. Patients at the Aravind Eye Care System in India were randomized to treatment with either topical natamycin or voriconazole.

The researchers found that 44 percent of the 323 patients enrolled presented on an antifungal agent. Larger mean baseline infiltrate size and epithelial defect size were seen in pretreated patients. Pretreatment was associated with significantly worse three-month visual acuity, larger three-month scar size, and increased odds of corneal perforation and/or transplant in multivariate analysis.

"Fungal keratitis that is smear-positive despite being pretreated with appropriate antifungal agents appears to be a risk factor for worse outcomes, likely due to initial ulcer severity and treatment failure," conclude the authors.

The drugs used in the study were donated by Alcon and Pfizer.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

FDA Approves New Parkinson's Add-On Drug Xadago

FDA Approves New Parkinson's Add-On Drug Xadago

To help prevent 'off' episodes among users of levodopa/carbidopa

Infant Mortality Down in United States From 2005 to 2014

Infant Mortality Down in United States From 2005 ...

Largest decreases seen for infants of Asian or Pacific Islander and non-Hispanic black women

Intensive Strategy Addresses Hypoxemia After Cardiac Surgery

Intensive Strategy Addresses Hypoxemia After Cardiac Surgery

Intensive alveolar recruitment strategy linked to less severe pulmonary complications after cardiac sx

is free, fast, and customized just for you!

Already a member?

Sign In Now »