No Need to Avoid Statins in Hep C Compensated Cirrhosis

This article originally appeared here.
Share this content:
No Need to Avoid Statins in Hep C Compensated Cirrhosis
No Need to Avoid Statins in Hep C Compensated Cirrhosis

WEDNESDAY, Feb. 10, 2016 (HealthDay News) -- Statin use is associated with decreased risk of cirrhosis decompensation and death in patients with hepatitis C virus (HCV)-related compensated cirrhosis, according to research published in the February issue of Gastroenterology.

Arpan Mohanty, M.B.B.S., of the VA Connecticut Healthcare System in West Haven, and colleagues used data from a retrospective cohort of 40,512 veterans (median age, 56 years) infected with HCV to examine the effects of statins on decompensation and survival times in patients with compensated cirrhosis.

The researchers identified 2,802 statin users and developed a propensity score model in which 685 statin users were matched with 2,062 nonusers. Compared with nonusers, statin users had a lower risk of decompensation (hazard ratio [HR], 0.55; 95 percent confidence interval [CI], 0.39 to 0.77) and death (HR, 0.56; 95 percent CI, 0.46 to 0.69). This association remained following adjustment for age, FIB-4 index score, serum level of albumin, model for end-stage liver disease and Child-Turcotte-Pugh scores.

"Based on data from the Veteran Affairs Clinical Case Registry, statin use among patients with HCV and compensated cirrhosis is associated with a more than 40 percent lower risk of cirrhosis decompensation and death," the authors write. "Although statins cannot yet be recommended widely for these patients, their use should not be avoided."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

AAP: Congress Urged to Act to Prevent Firearm Deaths

AAP: Congress Urged to Act to Prevent Firearm ...

Following latest shooting, pediatricians join call for action to be taken to address firearm deaths, injury

Lung Cancer Incidence Higher for Young Women Than Young Men

Lung Cancer Incidence Higher for Young Women Than ...

Crossover in sex-specific rates among U.S. non-Hispanic whites born since 1965

E-Cigarette Flavoring Agent May Impair Airway Defense System

E-Cigarette Flavoring Agent May Impair Airway Defense System

Flavoring commonly used in e-cigarettes suppresses cilia beat frequency, lasting for 60 minutes