No Increase in Acute Kidney Injury Risk for SGLT2 Users

Share this content:
No Increase in Acute Kidney Injury Risk for SGLT2 Users
No Increase in Acute Kidney Injury Risk for SGLT2 Users

THURSDAY, Aug. 24, 2017 (HealthDay News) -- The risk of acute kidney injury (AKI) is not increased for new sodium-glucose cotransporter-2 (SGLT2) inhibitor users, according to a study published online Aug. 21 in Diabetes Care.

Girish N. Nadkarni, M.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues assessed the real-world risk of AKI using data for 377 SGLT2 inhibitor users and 377 nonusers in the Mount Sinai chronic kidney disease registry and for 1,207 users and 1,207 nonusers in the Geisinger Health System cohort.

The researchers found that over a median follow-up of 14 months, 3.8 and 9.7 percent of SGLT2 users and nonusers in the Mount Sinai cohort, respectively, had an AKIKDIGO event (hazard ratio [HR], 0.4; 95 percent confidence interval [CI], 0.2 to 0.7; P = 0.01); the HR was unchanged after adjustment (adjusted HR, 0.4; 95 percent CI, 0.2 to 0.7; P = 0.004). Within the Geisinger cohort, 2.2 and 4.6 percent of users and nonusers, respectively, had an AKI KDIGO event. The unadjusted hazards of AKIKDIGO were lower in users (HR, 0.5; 95 percent CI, 0.3 to 0.8; P < 0.01); after adjustment for covariates there was modest attenuation (adjusted HR, 0.6; 95 percent CI, 0.4 to 1.1; P = 0.09).

"Our findings do not suggest an increased risk of AKI associated with SGLT2 inhibitor use in patients with type 2 diabetes in two large health systems," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions


Sign up for myCME e-newsletters


More in Home

FDA OKs Nucala for Eosinophilic Granulomatosis With Polyangiitis

FDA OKs Nucala for Eosinophilic Granulomatosis With Polyangiitis

First drug to be approved for rare autoimmune disease that leads to vasculitis

Findings Support Individualized Glycemic Control in T2DM

Findings Support Individualized Glycemic Control in T2DM

Approach saved $13,547/patient vs uniform intensive control, with lower medication costs

Atherosclerosis ID'd in Many Without CV Risk Factors

Atherosclerosis ID'd in Many Without CV Risk Factors

LDL-C independently associated with the presence and extent of atherosclerosis

is free, fast, and customized just for you!

Already a member?

Sign In Now »