No Benefit Found for Perioperative Statin Therapy

Share this content:
No Benefit Found for Perioperative Statin Therapy
No Benefit Found for Perioperative Statin Therapy

THURSDAY, May 5, 2016 (HealthDay News) -- Taking statins right before cardiac surgery, once touted as a way to prevent common postoperative complications, has no benefit and may even cause harm, according to a study published in the May 5 issue of the New England Journal of Medicine.

Barbara Casadei, M.D., a professor of cardiovascular medicine at the University of Oxford in the United Kingdom, and colleagues randomly assigned 1,922 patients who were having elective cardiac surgery to take rosuvastatin or placebo before surgery.

The researchers found that patients given rosuvastatin had lower levels of low-density lipoprotein cholesterol and C-reactive protein after surgery, compared with patients given a placebo. However, the percentages of those who developed atrial fibrillation were essentially the same in patients given rosuvastatin (21.1 percent) and those given a placebo (20.5 percent). Further analyses showed that rosuvastatin was associated with a 5.4 percent greater chance of acute kidney injury, when compared with a placebo.

"The risk of kidney injury is relatively small, but considering that the benefit of statin treatment before a heart operation is zero, one may well consider stopping statins for a few days before surgery," Casadei told HealthDay.

The study was funded in part by AstraZeneca, the manufacturer of rosuvastatin.

Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

More in Home

SABCS: Artificial Intelligence May Aid Doctors in Breast Cancer Care

SABCS: Artificial Intelligence May Aid Doctors in Breast ...

'Watson Oncology' agreed with doctors 90 percent of the time in many cases, researchers find

SABCS: Scalp-Cooling System Can Reduce Chemo-Related Hair Loss

SABCS: Scalp-Cooling System Can Reduce Chemo-Related Hair Loss

Devices reduce blood flow to hair follicles during chemotherapy treatments

SABCS: Aromatase Inhibitors Tied to Reduced Endothelial Function

SABCS: Aromatase Inhibitors Tied to Reduced Endothelial Function

Women on aromatase inhibitors exhibit less elasticity in their blood vessels

is free, fast, and customized just for you!

Already a member?

Sign In Now »