Neuronal GHS-R Involved in Regulating Energy Metabolism

This article originally appeared here.
Share this content:
Neuronal GHS-R Involved in Regulating Energy Metabolism
Neuronal GHS-R Involved in Regulating Energy Metabolism

FRIDAY, May 13, 2016 (HealthDay News) -- Neuronal growth hormone secretagogue receptor (GHS-R) is involved in regulating energy metabolism, according to an experimental study published online May 10 in Diabetes.

In an effort to understand the roles of neuronal GHS-R, Jong Han Lee, from the Baylor College of Medicine in Houston, and colleagues used Synapsin 1-Cre driver to generate a mouse line where Ghsr gene is deleted in all neurons.

The researchers found that neuronal deletion of Ghsr abolished ghrelin-induced spontaneous food intake, with no impact on total energy intake. Neuronal Ghsr deletion almost totally prevented diet-induced obesity (DIO) and correlated with a significant improvement in insulin sensitivity. Improved metabolic flexibility was seen for mice with neuronal Ghsr deletion. Gene expression analysis indicated that the hypothalamus and/or midbrain may be responsible for mediating the effects of GHS-R on thermogenesis and physical activity, respectively.

"Collectively, our results indicate that neuronal GHS-R is a crucial regulator of energy metabolism and a key mediator of DIO. Neuronal Ghsr deletion protects against DIO by regulating energy expenditure, not by energy intake," the authors write. "These novel findings suggest that suppressing central ghrelin signaling may serve as a unique anti-obesity strategy."

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Nocturia May Be Reduced by Cutting Daily Intake of Salt

Nocturia May Be Reduced by Cutting Daily Intake ...

An easy way for patients to reduce nighttime urination and subsequent impact on sleep

Smoking Ups Long-Term Risks From Radiotherapy in Breast CA

Smoking Ups Long-Term Risks From Radiotherapy in Breast ...

Risk associated with radiotherapy for breast cancer is substantially reduced with smoking cessation

Impact of Breastfeeding on Child Development May Be Short-Lived

Impact of Breastfeeding on Child Development May Be ...

After propensity matching, only statistically significant outcome was hyperactivity at age 3 years

is free, fast, and customized just for you!

Already a member?

Sign In Now »