Neuroimaging Predicts Post-Stroke Therapy Response

This article originally appeared here.
Share this content:
Neuroimaging Predicts Post-Stroke Therapy Response
Neuroimaging Predicts Post-Stroke Therapy Response

WEDNESDAY, Nov. 19, 2014 (HealthDay News) -- Response to post-stoke restorative therapy is best predicted by a model that includes measures of both neural injury and function, according to research published online Nov. 10 in the Annals of Neurology.

Erin Burke Quinlan, from the University of California at Irvine, and colleagues conducted a battery of assessments in 29 patients (three to six months post-stroke) prior to initiation of three weeks of standardized upper extremity robotic therapy.

The researchers found that predictors of treatment gains included smaller corticospinal tract (CST) injury, greater ipsilesional motor cortex (M1) activation, and greater inter-hemispheric M1-M1 connectivity. The best prediction was achieved, according to multivariate modeling, using both CST injury and M1-M1 connectivity (P = 0.002). No patient beyond the threshold of >63 percent CST injury achieved clinically significant gains. Results varied by stroke subtype. In patients with lacunar stroke, gains were exclusively predicted by a measure of intra-hemispheric connectivity.

"Neuroimaging measures were the best predictors and may have an ascendant role in clinical decision-making for post-stroke rehabilitation, which remains largely reliant on behavioral assessments," the authors write.

One author disclosed financial ties to the pharmaceutical and medical device industries.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease



Sign up for myCME e-newsletters




More in Home

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes found to transmit Zika virus

Periodontal Inflammation a Risk With Tongue Piercing

Periodontal Inflammation a Risk With Tongue Piercing

And, two young females with tongue piercings have deep lingual infrabony lesions, periodontitis

Risk of OD Highest for First Days of Opioid  Benzodiazepine Use

Risk of OD Highest for First Days of ...

Five-fold increased risk of opioid-related overdose during first 90 days of concurrent use

is free, fast, and customized just for you!




Already a member?

Sign In Now »