Negative Margins, Lymph Node Yields Predict Survival

Share this content:
Negative Margins, Lymph Node Yields Predict Survival
Negative Margins, Lymph Node Yields Predict Survival

MONDAY, Oct. 9, 2017 (HealthDay News) -- Patients treated at hospitals that attain a high rate of negative margins and lymph node yields (LNY) of at least 18 have improved survival after surgery for head and neck squamous cell carcinomas (HNSCC), according to a study published online Oct. 5 in JAMA Otolaryngology -- Head & Neck Surgery.

David W. Schoppy, M.D., Ph.D., from Stanford University in Palo Alto, California, and colleagues retrospectively reviewed records from the National Cancer Database to identify patients who underwent primary surgery and concurrent neck dissection for HNSCC between 2004 and 2013. They aimed to determine whether the percentage of patients with negative margins on primary resection and an LNY of 18 or more would predict outcomes.

The researchers identified 1,008 hospitals where 64,738 patients (69.8 percent male; mean age, 60.5) met inclusion criteria. Patients treated at hospitals attaining the combined metric of a 90 percent or higher negative margin rate and at least 80 percent of cases achieving LNY of 18 or more experienced a significant reduction in mortality (hazard ratio [HR], 0.93). This survival benefit was seen independent of patient-level improvement associated with negative margins (HR, 0.73) and LNY of 18 or more (HR, 0.85). The association of traditional measures of hospital quality (volume and teaching status) was neutralized when these metrics were included in a model.

"Tracking of these metrics may help identify high-quality centers and provide guidance for institution-level quality improvement," conclude the authors.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Older Adults Less Likely to Have Provider-Ordered Flu Testing

Older Adults Less Likely to Have Provider-Ordered Flu ...

Presence of influenza-like illness, younger age independently predict provider-ordered testing

Nutrients in Child's First 1,000 Days Key for Neurodevelopment

Nutrients in Child's First 1,000 Days Key for ...

Nutrition in prenatal period and first two years of life affects prenatal nutrient delivery, child development

In-Office Angiolytic Laser Effective for Vocal Polyps

In-Office Angiolytic Laser Effective for Vocal Polyps

Fewer adverse events for patients treated with laser plus concurrent polypectomy than laser alone

is free, fast, and customized just for you!

Already a member?

Sign In Now »