NAFLD Not Independently Tied to Risk of Reflux Esophagitis

This article originally appeared here.
Share this content:
NAFLD Not Independently Tied to Risk of Reflux Esophagitis
NAFLD Not Independently Tied to Risk of Reflux Esophagitis

MONDAY, Dec. 11, 2017 (HealthDay News) -- Nonalcoholic fatty liver disease (NAFLD) is not associated with increased risk of incident reflux esophagitis after adjustment for variables, including body mass index (BMI), according to a study published online Nov. 12 in the Journal of Gastroenterology and Hepatology.

In an effort to examine whether NAFLD is associated with incident reflux esophagitis, Yang Won Min, M.D., Ph.D., from Sungkyunkwan University School of Medicine in Seoul, South Korea, and colleagues conducted a cohort study involving 34,063 men and women without reflux esophagitis or other upper gastrointestinal disease. Participants underwent health check-up examinations between January 2003 and December 2013.

The researchers found that the prevalence of NAFLD was 33.2 percent at baseline. The cumulative incidences of reflux esophagitis were 9.6 and 13.8 percent for participants without and with NAFLD, respectively, during 153,520.2 person-years of follow-up (P < 0.001). Compared to those without NAFLD, participants with NAFLD had an age- and sex-adjusted hazard ratio of 1.15 for the risk of reflux esophagitis development (95 percent confidence interval, 1.07 to 1.23; P < 0.001). After adjustment for BMI and other metabolic factors, the association disappeared (hazard ratio, 1.01; 95 percent confidence interval, 0.94 to 1.09; P = 0.79). No significant correlation was seen between NAFLD severity and risk of developing reflux esophagitis in multivariable adjusted models.

"NAFLD is not independently associated with the risk of the development of reflux esophagitis, but rather reflux esophagitis is primarily the consequence of increased BMI commonly associated with NAFLD," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease


Sign up for myCME e-newsletters


More in Home

Proinflammatory Diet Linked to Increased Colorectal Cancer Risk

Proinflammatory Diet Linked to Increased Colorectal Cancer Risk

Higher empirical dietary inflammatory pattern score linked to increased risk of CRC for men and women

Longer Duration of Post-Op Opioid Use Associated With Misuse

Longer Duration of Post-Op Opioid Use Associated With ...

Higher dose, shorter duration Rx may minimize risk of longer term misuse, authors say

Alcohol Induced DNA Repair Genes Prognostic in Gastric Cancer

Alcohol Induced DNA Repair Genes Prognostic in Gastric ...

BRF1, BRCA1/2, MPO induced by alcohol have prognostic value for patients with gastric cancer

is free, fast, and customized just for you!

Already a member?

Sign In Now »