NAFLD Linked to Increased Cancer Incidence Rate

Share this content:
NAFLD Linked to Increased Cancer Incidence Rate
NAFLD Linked to Increased Cancer Incidence Rate

MONDAY, Nov. 20, 2017 (HealthDay News) -- Non-alcoholic fatty liver disease (NAFLD) is associated with development of cancer, specifically hepatocellular carcinoma (HCC), colorectal cancer in males, and breast cancer in females, according to a study published online Nov. 14 in the Journal of Hepatology.

Gi-Ae Kim, M.D., from the University of Ulsan College of Medicine in Seoul, South Korea, and colleagues conducted a historical cohort study to examine the correlation between NAFLD and cancer development. Data were included for 25,947 subjects who were followed for more than one year after having a health checkup; of these, 33.6 percent had NAFLD.

The researchers found that the cancer incidence rate was higher in the NAFLD group than the non-NAFLD group during a total follow-up of 164,671 person-years (782.9 versus 592.8 per 100,000 person-years; hazard ratio, 1.32). NAFLD was strongly associated with three cancers after adjustment for demographic and metabolic factors: HCC (hazard ratio, 16.73), colorectal cancer in males (hazard ratio, 2.01), and breast cancer in females (hazard ratio, 1.92). In addition, a high NAFLD fibrosis score and a high fibrosis-4 score were associated with the development of all cancers and HCC.

"These findings suggest that patients with NAFLD require multidisciplinary evaluation with attention given to the development of malignancy. Further studies are needed to specify which high-risk groups of patients with NAFLD carry a greater risk of developing cancers, including HCC, colorectal cancer, and breast cancer," the authors write.

Abstract/Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters


More in Home

Medicare Requiring Hospitals to Post Prices Online

Medicare Requiring Hospitals to Post Prices Online

Medicare would base part of a hospital's payments on how easy it is for patients to access medical records

Restless Brain Syndrome Tied to Changes in the Brain

Restless Brain Syndrome Tied to Changes in the ...

Morphological differences seen in the primary somatosensory system

People With Opioid Use Disorder Have High Suicide Rate

People With Opioid Use Disorder Have High Suicide ...

Based on data from multiple sources, many opioid-overdose deaths seem to be suicides

is free, fast, and customized just for you!

Already a member?

Sign In Now »