Multiple Plaque Ruptures, Larger Cavities for IPST in PCI

This article originally appeared here.
Share this content:
Multiple Plaque Ruptures, Larger Cavities for IPST in PCI
Multiple Plaque Ruptures, Larger Cavities for IPST in PCI

MONDAY, March 7, 2016 (HealthDay News) -- Multiple plaque ruptures with larger cavities are seen more often in patients with intraprocedural stent thrombosis (IPST) during percutaneous coronary intervention, according to a study published in the March 15 issue of The American Journal of Cardiology.

Toru Morofuji, M.D., from Kitaishikai Hospital in Ozu, Japan, and colleagues used intravascular ultrasound (IVUS) to examine lesion characteristics in patients with IPST. They analyzed 1,504 consecutive stent-implanted lesions in 1,324 patients. Of these, IPST occurred in five patients during percutaneous coronary intervention. The IVUS characteristics of plaques that developed IPST were compared with those of 15 control plaques, without evidence of IPST.

The researchers found that all lesions that led to IPST had ruptured plaques with evidence of positive remodeling and attenuation. Plaque rupture was seen in 40 percent of plaques in the non-IPST group. The IPST group more often had multiple plaque ruptures in the culprit lesion (80 versus 7 percent; P < 0.01). The IPST group had a larger maximum cavity area compared with the non-IPST group having plaque rupture (4.6 versus 2.4 mm²; P < 0.01).

"In conclusion, we found using IVUS that multiple plaque ruptures with larger cavities more often evolved into IPST," the authors write.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!




Already a member?

Sign In Now »

Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions



Sign up for myCME e-newsletters




More in Home

FDA Approves Palynziq for Phenylketonuria

FDA Approves Palynziq for Phenylketonuria

Drug is a novel enzyme therapy for adult patients with PKU with uncontrolled blood Phe concentrations

Increase in Tx Candidates With 2017 Hypertension Guidelines

Increase in Tx Candidates With 2017 Hypertension Guidelines

Increase in proportion of adults recommended for treatment; estimated decrease in CVD events, deaths