Morphine Effects Similar to Placebo in Rheumatoid Arthritis

This article originally appeared here.
Share this content:
Morphine Effects Similar to Placebo in Rheumatoid Arthritis
Morphine Effects Similar to Placebo in Rheumatoid Arthritis

THURSDAY, July 27, 2017 (HealthDay News) -- For patients with chronic fatigue syndrome (CFS)/fibromyalgia (FM) or rheumatoid arthritis (RA), morphine has anti-hyperalgesic effects comparable to placebo, according to a study published online July 19 in PAIN Practice.

Linda Hermans, P.T., from Ghent University in Belgium, and colleagues conducted a randomized, double-blind, placebo-controlled trial. Ten patients with CFS/FM, 11 with RA, and 20 controls were randomized to experimental (10 mg morphine/0.2 mg/mL naloxone) and placebo groups.

The researchers found that at baseline, compared with controls, patients with CFS/FM and RA had lower deep tissue pain pressure and higher temporal summation. In both patient groups, morphine had a positive effect only on pressure pain thresholds (PPTs); PPTs increased after placebo, but no effects on other pain parameters were objectified. Neither naloxone nor nocebo had significant effects on PPT, deep tissue pain, temporal summation, or conditioned pain modulation (CPM) in the control group.

"The effect of morphine in central sensitization patients appears limited and could have more effect on a peripheral level. Nevertheless, the morphine effect on experimental pain measures was comparable to the effect of placebo," the authors write. "Naloxone did not significantly affect nociceptive modulation in the healthy participants. These results suggest that temporal summation and conditioned pain modulation are not primarily mediated by opioid mechanisms."

One author disclosed financial ties to the pharmaceutical industry.

Abstract
Full Text (subscription or payment may be required)

Share this content:

is free, fast, and customized just for you!

Already a member?

Sign In Now »


Sign up for myCME e-newsletters


Drug Lookup

Browse drugs by: BrandGenericDisease

Trending Activities

All Professions

More in Home

Zika Does Not Appear to Last in Semen As Long As Thought

Zika Does Not Appear to Last in Semen ...

More research is needed to better inform public health recommendations

Radioiodine Therapy for Thyroid Cancer Doesn't Up Stroke Risk

Radioiodine Therapy for Thyroid Cancer Doesn't Up Stroke ...

I-131 therapy group showed no significantly higher risk of ischemic or hemorrhagic stroke

Higher Odds of Infection With Reduced Kidney Function

Higher Odds of Infection With Reduced Kidney Function

Study finds excess community-acquired infections incidence in individuals with mild to severe CKD

is free, fast, and customized just for you!

Already a member?

Sign In Now »